An anonymous reader quotes a report from STAT News: Health insurance companies have rejected medical claims for as long as they've been around. But a STAT investigation found artificial intelligence is now driving their denials to new heights in Medicare Advantage, the taxpayer-funded alternative to traditional Medicare that covers more than 31 million people. Behind the scenes, insurers are using unregulated predictive algorithms, under the guise of scientific rigor, to pinpoint the precise moment when they can plausibly cut off payment for an older patient's treatment. The denials that follow are setting off heated disputes between doctors and insurers, often delaying treatment of seriously ill patients who are neither aware of the algorithms, nor able to question their calculations. Older people who spent their lives paying into Medicare, and are now facing amputation, fast-spreading cancers, and other devastating diagnoses, are left to either pay for their care themselves or get by without it. If they disagree, they can file an appeal, and spend months trying to recover their costs, even if they don't recover from their illnesses.

The algorithms sit at the beginning of the process, promising to deliver personalized care and better outcomes. But patient advocates said in many cases they do the exact opposite -- spitting out recommendations that fail to adjust for a patient's individual circumstances and conflict with basic rules on what Medicare plans must cover. "While the firms say [the algorithm] is suggestive, it ends up being a hard-and-fast rule that the plan or the care management firms really try to follow," said David Lipschutz, associate director of the Center for Medicare Advocacy, a nonprofit group that has reviewed such denials for more than two years in its work with Medicare patients. "There's no deviation from it, no accounting for changes in condition, no accounting for situations in which a person could use more care."

STAT's investigation revealed these tools are becoming increasingly influential in decisions about patient care and coverage. The investigation is based on a review of hundreds of pages of federal records, court filings, and confidential corporate documents, as well as interviews with physicians, insurance executives, policy experts, lawyers, patient advocates, and family members of Medicare Advantage beneficiaries. It found that, for all of AI's power to crunch data, insurers with huge financial interests are leveraging it to help make life-altering decisions with little independent oversight. AI models used by physicians to detect diseases such as cancer, or suggest the most effective treatment, are evaluated by the Food and Drug Administration. But tools used by insurers in deciding whether those treatments should be paid for are not subjected to the same scrutiny, even though they also influence the care of the nation's sickest patients.

A group of psychologists, two from Northwestern University and the third from the University of Oregon, has found via online testing that IQ scores in the U.S. may be dropping for the first time in nearly a century. Phys.Org reports: In this new effort, the researchers studied the results of online IQ tests taken by adults participating in the Synthetic Aperture Personality Assessment Project over a 12-year period. They found that IQ scores have dropped for all age groups, regardless of gender. They also found that the steepest declines were among young people. They also noted that while a few skills, such as spatial reasoning, were better than previous generations, other skills, such as problem solving, numerical series assessments and verbal reasoning, had all grown worse.

The researchers did not conduct any research to try to explain the drop, but suggest it might be linked to changes in the education system. They also did not address the controversial issue of the accuracy of IQ test scores in general as a means of measuring a person's intelligence. The paper has been published in the journal Intelligence.

All toilet paper from across the globe checked for toxic PFAS "forever chemicals" contained the compounds, and the waste flushed down toilets and sent to sewage treatment plants probably creates a significant source of water pollution, new research has found. From a report: Once in the wastewater plant, the chemicals can be packed in sewage sludge that is eventually spread on cropland as fertilizer, or spilt into waterways. "Toilet paper should be considered as a potentially major source of PFAS entering wastewater treatment systems," the study's authors wrote. PFAS are a class of about 14,000 chemicals typically used to make thousands of consumer products resist water, stains and heat. They are called "forever chemicals" because they do not naturally break down, and they are linked to cancer, fetal complications, liver disease, kidney disease, autoimmune disorders and other serious health issues.

The study checked 21 major toilet paper brands in North America, western Europe, Africa, Central America and South America, but it did not name the brands. The peer-reviewed University of Florida report did not consider the health implications of people wiping with contaminated toilet paper. PFAS can be dermally absorbed, but no research on how it may enter the body during the wiping process exists. However, that exposure is "definitely worth investigating," said David Andrews, senior scientist with the Environmental Working group, a public health non-profit that tracks PFAS pollution.

Slashdot readers madsh, Ellis Haney, and sciencehabit all submitted this report from Science: A recent study, scheduled to be presented at an upcoming computer vision conference, demonstrates that AI can read brain scans and re-create largely realistic versions of images a person has seen....

Many labs have used AI to read brain scans and re-create images a subject has recently seen, such as human faces and photos of landscapes. The new study marks the first time an AI algorithm called Stable Diffusion, developed by a German group and publicly released in 2022, has been used to do this.... For the new study, a group in Japan added additional training to the standard Stable Diffusion system, linking additional text descriptions about thousands of photos to brain patterns elicited when those photos were observed by participants in brain scan studies. Unlike previous efforts using AI algorithms to decipher brain scans, which had to be trained on large data sets, Stable Diffusion was able to get more out of less training for each participant by incorporating photo captions into the algorithm....

The AI algorithm makes use of information gathered from different regions of the brain involved in image perception, such as the occipital and temporal lobes, according to Yu Takagi, a systems neuroscientist at Osaka University who worked on the experiment. The system interpreted information from functional magnetic resonance imaging (fMRI) brain scans, which detect changes in blood flow to active regions of the brain. When people look at a photo, the temporal lobes predominantly register information about the contents of the image (people, objects, or scenery), whereas the occipital lobe predominantly registers information about layout and perspective, such as the scale and position of the contents. All of this information is recorded by the fMRI as it captures peaks in brain activity, and these patterns can then be reconverted into an imitation image using AI. In the new study, the researchers added additional training to the Stable Diffusion algorithm using an online data set provided by the University of Minnesota, which consisted of brain scans from four participants as they each viewed a set of 10,000 photos.
If a study participant showed the same brain pattern, the algorithm sent words from that photo's caption to Stable Diffusion's text-to-image generator.

Iris Groen, a neuroscientist at the University of Amsterdam who was not involved with the work, told Science that "The accuracy of this new method is impressive."

"Based on initial data review, vehicle is healthy," Relativity Space tweeted today. "More info to follow on cause of aborts today. Thanks for playing."

Remaining back on the launchpad is the largest 3D printed object ever to exist. And they're still hoping to launch it into space.

They'd planned a launch this morning from Cape Canaveral, Florida of a 110-foot rocket (33.5 meters) on a mission they're calling GLHF — "Good Luck, Have Fun".

The rocket's makers — California-based Relativity Space — call it "the world's first 3D printed rocket." A full 85% of the rocket's weight comes from 3D printed parts, explains Wired, and "only the computing system, electronics, and readily available parts like fasteners were not." Named Terran 1, the 7.5-foot-wide rocket (2.2 meters) inaugurates the company's ambitious plans for 3D printing in space: Relativity Space wants to use Terran 1 to (comparatively) cheaply lift satellites for other companies and NASA into Earth orbit. It also plans to construct Terran R, a larger, more powerful, fully reusable rocket that the company hopes will compete with SpaceX's Falcon 9, which has a smaller payload capacity and only reuses the rocket's first stage. In late 2024, Relativity plans to test using Terran R to launch payloads to Mars; another startup, Impulse Space, will provide the lander.
From the company's web site: Like its structure, all Relativity engines are 3D printed and use liquid oxygen and liquid natural gas, which are not only the best for rocket propulsion, but also for reusability, and the easiest to eventually transition to methane on Mars.
The tagline for the company's Twitter feed says they're "Building humanity's multiplanetary future." And excitement is running high, reports Spaceflight Now" "There are a number of firsts here potentially on this rocket," said Josh Brost, vice president of revenue operations at Relativity Space....

"Hard to believe the day is nearly here to launch Terran 1, our first rocket!" Tim Ellis, co-founder and CEO of Relativity Space tweeted Tuesday....

The company now boasts some 1,000 employees, a million-square-foot headquarters and factory in Long Beach, California, and $1.3 billion in venture capital and equity fundraising, including an early $500,000 investment from billionaire Mark Cuban. In 2021, the company reached a valuation of $4.2 billion before launching any rockets....

"No new company has ever had their liquid rocket make it to space on their first attempt," Brost, also a former engineer and manager at SpaceX, told Spaceflight Now in a pre-launch interview. "So if everything goes incredibly well, and we achieve orbit on our first launch ... that would be a remarkable milestone for us, which we would be, of course, over the moon excited about. But that doesn't define success for us."
Wired adds that they're not the only company working on space-related 3D printing: Australia's Fleet Space has already been producing lightweight, 3D-printed radio frequency antennas for satellites. Next year, using printers half the size of a bus, they plan to create a satellite constellation called Alpha that will be entirely 3D-printed.... Flavia Tata Nardini, the company's CEO, believes space-based 3D printing is coming next. "In my ideal future, in 10 to 15 years, I won't have to launch satellites from here; I can build them up there."

Slashdot reader beforewisdom shared this report from CNN: Scientists have set out a way to suck planet-heating carbon pollution from the air, turn it into sodium bicarbonate and store it in oceans, according to a new paper. The technique could be up to three times more efficient than current carbon capture technology, say the authors of the study, published Wednesday in the journal Science Advances....

The team have used copper to modify the absorbent material used in direct air capture. The result is an absorbent "which can remove CO2 from the atmosphere at ultra-dilute concentration at a capacity which is two to three times greater than existing absorbents," Arup SenGupta, a professor at Lehigh University and a study author, told CNN. This material can be produced easily and cheaply and would help drive down the costs of direct air capture, he added. Once the carbon dioxide is captured, it can then be turned into sodium bicarbonate — baking soda — using seawater and released into the ocean at a small concentration.

The oceans "are infinite sinks," SenGupta said. "If you put all the CO2 from the atmosphere, emitted every day — or every year — into the ocean, the increase in concentration would be very, very minor," he said. SenGupta's idea is that direct air capture plants can be located offshore, giving them access to abundant amounts of seawater for the process.

Stuart Haszeldine, professor of carbon capture and storage at the University of Edinburgh, who was not involved in the study, told CNN that the chemistry was "novel and elegant." The process is a modification of one we already know, he said, "which is easier to understand, scale-up and develop than something totally new."

Chronic pain patients were implanted with "dummy" pieces of plastic and told it would ease their pain, according to an indictment charging the former CEO of the firm that made the fake devices with fraud. Motherboard reports: Laura Perryman, the former CEO of Stimwave LLC, was arrested in Florida on Thursday. According to an FBI press release, Perryman was indicted "in connection with a scheme to create and sell a non-functioning dummy medical device for implantation into patients suffering from chronic pain, resulting in millions of dollars in losses to federal healthcare programs." According to the indictment, patients underwent unnecessary implanting procedures as a result of the fraud. Perryman was charged with one count of conspiracy to commit wire fraud and health care fraud, and one count of healthcare fraud. Stimwave received FDA approval in 2014, according to Engadget, and was positioned as an alternative to opioids for pain relief.

The Stimwave "Pink Stylet" system consisted of an implantable electrode array for stimulating the target nerve, a battery worn externally that powered it, and a separate, 9-inch long implantable receiver. When doctors told Stimwave that the long receiver was difficult to place in some patients, Perryman allegedly created the "White Stylet," a receiver that doctors could cut to be smaller and easier to implant -- but was actually just a piece of plastic that did nothing. "To perpetuate the lie that the White Stylet was functional, Perryman oversaw training that suggested to doctors that the White Stylet was a 'receiver,' when, in fact, it was made entirely of plastic, contained no copper, and therefore had no conductivity," the FBI stated. "In addition, Perryman directed other Stimwave employees to vouch for the efficacy of the White Stylet, when she knew that the White Stylet was actually non-functional." Stimwave charged doctors and medical providers approximately $16,000 for the device, which medical insurance providers, including Medicare, would reimburse the doctors' offices for.

An anonymous reader quotes a report from Popular Mechanics: [S]cientists from the University of Cambridge and Johns Hopkins University announced that they'd finally mapped every single neuron and all the connections between them housed inside the brain of a fruit fly larva. The team's research was published this week in the journal Science. "If we want to understand who we are and how we think, part of that is understanding the mechanism of thought," says Johns Hopkins biomedical engineer Joshua T. Vogelstein in a press release. "And the key to that is knowing how neurons connect with each other."

And there are a lot of neurons and connections to sort through. To complete this neurological map, scientists had to identify 3,016 neurons. But that pales in comparison to the number of connections between these neurons, which comes to a grand total of 548,000. They also identified 93 distinct neurons that differed in shape, function, and neurological connection. If this all sounds difficult, that's because it is. For 12 years, scientists had to painstakingly slice a brain into thousands of tissue samples, image them with an high-resolution electron microscope, and then piece them back together -- neuron by neuron.

Understanding the inner workings of a fruit fly's brain may seem unrelated to the human mind, but scientists didn't choose this particular species based on its size or perceived simplicity -- rather, fruit flies actually share fundamental biology and a comparable genetic foundation with humans. This makes the map a perfect cornerstone upon which to explore some of the many mysteries of the human mind. "All brains are similar -- they are all networks of interconnected neurons," Marta Zaltic, a co-author on the study, told the BBC. "All brains of all species have to perform many complex behaviors: they all need to process sensory information, learn, select actions, navigate their environments, choose food, etc."

A newly discovered asteroid roughly the size of an Olympic swimming pool has a "small chance" of colliding with Earth in 23 years, with a potential impact on Valentine's Day in 2046, according to NASA's Planetary Defense Coordination Office. From a report: The asteroid has a 1 in 625 chance of striking Earth, based on data projections from the European Space Agency, though NASA's Jet Propulsion Laboratory's Sentry system calculated the odds closer to 1 in 560. The latter tracks potential collisions with celestial objects. But the space rock -- named 2023 DW -- is the only object on NASA's risk list that ranks 1 out of 10 on the Torino Impact Hazard Scale, a metric for categorizing the projected risk of an object colliding with Earth. All other objects rank at 0 on the Torino scale.

NASA officials have warned that the odds of impact could be dramatically altered as more observations of 2023 DW are collected and additional analysis is performed. It may be a few days before new data can be collected because of the asteroid's proximity to the moon [...]. The last full moon was two days ago, and it still appears bright and large in the sky, likely obscuring 2023 DW from immediate observation.

The asteroid measures about 160 feet (about 50 meters) in diameter, according to NASA data. As 2023 DW orbits the sun, it has 10 predicted close approaches to Earth, with the nearest landing on February 14, 2046, and nine others between 2047 and 2054. The closest the asteroid is expected to travel to Earth is about 1.1 million miles (1.8 million kilometers), NASA's Eyes on Asteroids website notes. The space rock was first spotted in our skies on February 2. It's traveling about 15.5 miles per second (25 kilometers per second) at a distance of more than 11 million miles (18 million kilometers) from Earth, completing one loop around the sun every 271 days.

An anonymous reader quotes a report from Phys.Org: Australian scientists have discovered an enzyme that converts air into energy. The finding, published in the journal Nature, reveals that this enzyme uses the low amounts of the hydrogen in the atmosphere to create an electrical current. This finding opens the way to create devices that literally make energy from thin air. The research team, led by Dr. Rhys Grinter, Ph.D. student Ashleigh Kropp, and Professor Chris Greening from the Monash University Biomedicine Discovery Institute in Melbourne, Australia, produced and analyzed a hydrogen-consuming enzyme from a common soil bacterium.

In this Nature paper, the researchers extracted the enzyme responsible for using atmospheric hydrogen from a bacterium called Mycobacterium smegmatis. They showed that this enzyme, called Huc, turns hydrogen gas into an electrical current. Dr. Grinter notes, "Huc is extraordinarily efficient. Unlike all other known enzymes and chemical catalysts, it even consumes hydrogen below atmospheric levels -- as little as 0.00005% of the air we breathe." The researchers used several cutting-edge methods to reveal the molecular blueprint of atmospheric hydrogen oxidation. They used advanced microscopy (cryo-EM) to determine its atomic structure and electrical pathways, pushing boundaries to produce the most resolved enzyme structure reported by this method to date. They also used a technique called electrochemistry to demonstrate the purified enzyme creates electricity at minute hydrogen concentrations.

Laboratory work performed by Kropp shows that it is possible to store purified Huc for long periods. "It is astonishingly stable. It is possible to freeze the enzyme or heat it to 80 degrees celsius, and it retains its power to generate energy," Kropp said. "This reflects that this enzyme helps bacteria to survive in the most extreme environments. " Huc is a "natural battery" that produces a sustained electrical current from air or added hydrogen. While this research is at an early stage, the discovery of Huc has considerable potential to develop small air-powered devices, for example as an alternative to solar-powered devices. "Once we produce Huc in sufficient quantities, the sky is quite literally the limit for using it to produce clean energy."

Covid-19 may not have taken as great a toll on the mental health of most people as earlier research has indicated, a new study suggests. From a report: The pandemic resulted in "minimal" changes in mental health symptoms among the general population, according to a review of 137 studies from around the world led by researchers at McGill University in Canada, and published in the British Medical Journal. Brett Thombs, a psychiatry professor at McGill University and senior author, said some of the public narrative around the mental health impacts of Covid-19 were based on "poor-quality studies and anecdotes," which became "self-fulfilling prophecies," adding that there was a need for more "rigorous science."

However, some experts disputed this, warning such readings could obscure the impact on individual groups such as children, women and people with low incomes or pre-existing mental health problems. They also said other robust studies had reached different conclusions. Thombs said: "Mental health in Covid-19 is much more nuanced than people have made it out to be. Claims that the mental health of most people has deteriorated significantly during the pandemic have been based primarily on individual studies that are 'snapshots' of a particular situation, in a particular place, at a particular time. They typically don't involve any long-term comparison with what had existed before or came after."

Scientists have created mice with two biological fathers by generating eggs from male cells, a development that opens up radical new possibilities for reproduction. The Guardian reports: The advance could ultimately pave the way for treatments for severe forms of infertility, as well as raising the tantalizing prospect of same-sex couples being able to have a biological child together in the future. "This is the first case of making robust mammal oocytes from male cells," said Katsuhiko Hayashi, who led the work at Kyushu University in Japan and is internationally renowned as a pioneer in the field of lab-grown eggs and sperm. Hayashi, who presented the development at the Third International Summit on Human Genome Editing at the Francis Crick Institute in London on Wednesday, predicts that it will be technically possible to create a viable human egg from a male skin cell within a decade. Others suggested this timeline was optimistic given that scientists are yet to create viable lab-grown human eggs from female cells.

The study, which has been submitted for publication in a leading journal, relied on a sequence of intricate steps to transform a skin cell, carrying the male XY chromosome combination, into an egg, with the female XX version. Male skin cells were reprogrammed into a stem cell-like state to create so-called induced pluripotent stem (iPS) cells. The Y-chromosome of these cells was then deleted and replaced by an X chromosome "borrowed" from another cell to produce iPS cells with two identical X chromosomes. "The trick of this, the biggest trick, is the duplication of the X chromosome," said Hayashi. "We really tried to establish a system to duplicate the X chromosome."

Finally, the cells were cultivated in an ovary organoid, a culture system designed to replicate the conditions inside a mouse ovary. When the eggs were fertilized with normal sperm, the scientists obtained about 600 embryos, which were implanted into surrogate mice, resulting in the birth of seven mouse pups. The efficiency of about 1% was lower than the efficiency achieved with normal female-derived eggs, where about 5% of embryos went on to produce a live birth. The baby mice appeared healthy, had a normal lifespan, and went on to have offspring as adults. "They look OK, they look to be growing normally, they become fathers," said Hayashi. He and colleagues are now attempting to replicate the creation of lab-grown eggs using human cells.

sciencehabit shares a report from Science Magazine: Has the quest for room temperature superconductivity finally succeeded? Researchers at the University of Rochester (U of R), who previously were forced to retract a controversial claim of room temperature superconductivity at high pressures, are back with an even more spectacular claim. This week in Nature they report a new material that superconducts at room temperature -- and not much more than ambient pressures. "If this is correct, it's completely revolutionary," says James Hamlin, a physicist at the University of Florida who was not involved with the work. A room temperature superconductor would usher in a century-long dream. Existing superconductors require expensive and bulky chilling systems to conduct electricity frictionlessly, but room temperature materials could lead to hyperefficient electricity grids and computer chips, as well as the ultrapowerful magnets needed for levitating trains and fusion power. [...]

On February 22, [physicist Ranga Dias] and his colleagues doubled down on their original claim. In a preprint posted on arXiv they reported synthesizing a new version of CSH that superconducts at a slightly lower 260 K, but at only about half the previous pressure. "This should clear up any questions regarding CSH," says co-author Russell Hemley, an x-ray crystallographer at the University of Illinois, Chicago, who helped determine the material's structure. Now comes the even more promising substance: nitrogen-doped lutetium-hydride (LNH). To make it, Dias's team loaded a thin lutetium foil in a diamond vise and injected a mix of hydrogen and nitrogen gas. By ramping the pressure up to 2 gigapascals (nearly 20,000 times atmospheric pressure) and baking the mix at 200C for up to 3 days, they forged a bright blue crystalline fleck, one that survived even after the pressure was eased.

When they dialed the pressure back up to as little as 0.3 gigapascals, the blue fleck turned pink as the electrical resistance plunged to zero. The substance reached a peak superconducting temperature of 294 K-7-degrees warmer than the original CSH and truly room temperature -- at pressures of 1 gigapascal. Magnetic measurements also showed the sample repelled an externally applied magnetic field, a hallmark of superconductors. The paper, the authors say, went through five rounds of review. Given the U of R group's recent retraction, many physicists won't be easily convinced. "I think they will have to do some real work and be really open for people to believe it," Hamlin says. Jorge Hirsch, a physicist at the University of California, San Diego, and a vociferous critic of the earlier work, is even more blunt. "I doubt [the new result], because I don't trust these authors."

Moderna Chief Executive Stephane Bancel pushed back against criticism of the company's pricing plans for its Covid-19 vaccine at Wall Street Journal Health Forum. From the report: U.S. politicians including Sens. Bernie Sanders (I., Vt.), Elizabeth Warren (D., Mass.) and Peter Welch (D., Vt.) have questioned the company's strategy around commercial pricing, which could be unveiled in the coming months. Moderna received funding from the U.S. government related to development of its Covid-19 vaccine. The chief executive said the company's mRNA platform was funded by investors, not the government, and the public funding accelerated development of the vaccine. "We didn't get a penny,â Mr. Bancel said of Moderna's fundraising efforts, adding that the company unsuccessfully sought funding in the first half of 2020 from countries and foundations to help with manufacturing. He said a company plant was built before the pandemic by private funding.

Moderna has said it is considering pricing its Covid-19 vaccine in a range of $110 to $130 a dose in the U.S. when it shifts from government contracting to commercial distribution of the shots. Mr. Bancel on Monday declined to say what the price will be. He said the company has plans so that the vaccine won't cost anything to individuals. After promising early-stage data of the shot came out, Moderna raised money, which it put toward manufacturing doses of the vaccine, still without knowing whether it would work, Mr. Bancel said. The company worked with suppliers to increase manufacturing, he said.

The launch of Japan's H3 rocket on Tuesday morning, local time in Tanegashima, failed after the vehicle's second-stage engine did not ignite. From a report: In a terse statement on the failure, Japanese space agency JAXA said, "A destruct command has been transmitted to H3 around 10:52 am (Japan Standard Time), because there was no possibility of achieving the mission. We are confirming the situation." The Japanese space agency, in concert with the rocket's manufacturer, Mitsubishi Heavy Industries, has spent about $1.5 billion developing the H3 rocket over the last decade. Much of the challenge in building the new rocket involved development of a new LE-9 engine, which is fueled by liquid hydrogen and liquid oxygen, to power the first stage. This appeared to perform flawlessly. The second-stage engine that failed, the LE-5B, was a more established engine.

The country has sought to increase its share of the commercial launch market by building a lower-cost alternative to its older H2-A vehicle to more effectively compete with SpaceX's Falcon 9 booster. Mitsubishi's goal was to sell the H3 at $51 million per launch in its base configuration. This would allow the company to supplement its launches of institutional missions for the Japanese government with commercial satellites. Tuesday's debut flight of the H3 rocket carried the Advanced Land Observing Satellite-3 for the Japanese government. It was lost. Japanese officials expressed dissatisfaction after the rocket's failure. Japan's minister of Education, Culture, Sports, Science, and Technology Science, Keiko Nagaoka, said the launch failure was "extremely regrettable." She added that a task force would work with JAXA to "promptly and thoroughly" determine what caused the failure.

Artificial sweeteners and other sugar substitutes sweeten foods without extra calories. But studies show the ingredients can affect gut and heart health. From a report: Table sugar, or sucrose, is still the dominant sweetener in the food supply, and eating a lot of ultra-processed foods with added sugar has been linked to chronic illness and obesity. The number of new food products containing sucrose has fallen by 16 percent in the last five years. Use of high-fructose corn syrup and agave syrup also have declined. "These low-calorie sweeteners are ubiquitous in the food supply, and so people often aren't even aware that they're consuming them," said Allison Sylvetsky, an associate professor in the department of exercise and nutrition sciences at George Washington University. Many sugar substitutes are known as high-intensity sweeteners because they're often hundreds of times sweeter than table sugar.

Some are synthetic, like sucralose, aspartame, and saccharin, while others, like allulose, stevia and monk fruit extract, are referred to as "natural" because they're derived from plants. Sugar substitutes can be found in ingredient lists on food packages, often with names that many consumers don't recognize, like adventame, neotame and acesulfame potassium. Foods that claim "no artificial sweeteners" often are sweetened with stevia and other so-called "natural" sugar substitutes. A variety of these sweeteners are turning up in cereals, juices and other packaged foods marketed to kids -- even though public health groups have discouraged their use among children. Sucralose and acesulfame potassium are regularly used in Greek yogurts, tortilla wraps and other foods served in school meals. Schools in some states have experimented with serving chocolate milk sweetened with a blend of sugar and monk fruit extract. [...] Scientists used to think that non-nutritive sweeteners were largely inert, activating sweet receptors on our tongues and passing through our bodies without causing metabolic changes. But questions remain about the health effects of consuming large amounts of these ingredients. The World Health Organization cautioned people to limit their intake of sugar substitutes because of their potential for "undesirable" long-term effects, including detrimental effects on gut and metabolic health.

NASA's Orion spacecraft performed better than expected on its first deep-space flight despite experiencing unpredicted loss of its heat shield material. Space.com reports: During Tuesday's call, NASA program managers revealed that Orion's heat shield did not perform as expected, losing more material than the agency had planned for. Nevertheless, NASA leadership is confident that everything will be ready for the crewed around-the-moon flight of Artemis 2, which is planned for next year. Howard Hu, manager of NASA's Orion Program, lauded the crew module's performance during the test flight, noting that NASA was able to accomplish 161 overall test objectives planned for the mission, even adding an additional 21 during the flight based on the spacecraft's performance.

"We also accomplished what our number one objective was, which is returning the crew module back to Earth safely from 24,500 miles per hour to a landing about 16 miles per hour when it touched down, and we were able to land within 2.4 miles of our target," Hu said during Tuesday's teleconference. "Our requirement was 6.2 miles. So, really great performance as we were able to return back from the moon." "Some of the expected char material that we would expect coming back home ablated away differently than what our computer models and what our ground testing predicted," Hu said. "So we had more liberation of the charred material during reentry before we landed than we had expected."

Hu explained that NASA teams are investigating a wide range of data related to the performance of Orion's heat shield, including images and videos of reentry, onboard sensor readings, and even X-ray images of sample materials taken from the shield. "Overall, there's a lot of work to be done in this investigation going forward," Hu said. "We are just starting that effort because we've just gotten together all those pieces of information. Those samples, the videos, images, and the data from the spacecraft itself and correlated them together. And now we're assessing that data and moving forward with that assessment." Despite the heat shield issue, NASA says they feel confident that the crewed Artemis 2 mission will be able to launch on schedule in 2024.

"NASA is currently aiming to launch Artemis 2 in November 2024," adds Space.com. "The mission will send a crew of astronauts on an eight-day mission around the moon and back to test Orion's performance, crew interfaces, and guidance and navigation systems."

Nearly everyone -- 99 percent of the global population -- is exposed to unhealthy levels of tiny and harmful air pollutants, known as PM 2.5, according a new study released Monday in Lancet Planet Health. From a report: The findings underline a growing urgency for policymakers, public health officials and researchers to focus on curbing major sources of air pollution, such as emissions from power plants, industrial facilities and vehicles. "Almost no one is safe from air pollution," Yuming Guo, the lead author of the study and professor at Monash University, said in an email. "The surprising result is that almost all parts of the world have annual average PM 2.5 concentrations higher than air quality guidelines recommended by the World Health Organization." Nearly 7 million people worldwide died from air pollution in 2019, according to recent estimates. What's known as PM 2.5, small air particles that measure 2.5 microns or less in width rank as one of the most concerning toxic air pollutants for human health. The tiny pollutants -- one-thirtieth the width of a human hair -- can travel into our lungs and bloodstream. They can cause ailments including heart disease or lung cancer.

Guo and his colleagues assessed daily and annual PM 2.5 concentrations across the globe from 2000 to 2019 using a computer model, which incorporated traditional air quality observations from ground stations, chemical transport model simulations and meteorological data. Overall, the highest concentrations were located in eastern Asia, southern Asia and northern Africa. In 2019, they found 0.001 percent of the global population is exposed to levels of PM 2.5 pollution that the World Health Organization deems safe. The agency has said annual concentrations higher than 5 micrograms per cubic meter are hazardous. Additionally, the study found that across the globe, 70 percent of days in a year were above recommended PM 2.5 levels.

Unprecedented access to space is leading to all sorts of cool new ideas, including the prospect of storing data on the lunar surface. Cloud computing startup Lonestar Data Holdings announced the results of its latest funding round, taking it one step closer to this very goal. Gizmodo reports: The Florida-based company raised $5 million in seed funding to establish lunar data centers, Lonestar announced in a press release on Monday. Lonestar wants to build a series of data centers on the Moon and establish a viable platform for data storage and edge processing (i.e. the practice of processing data near the source, as a means to reduce latency and improve bandwidth) on the lunar surface. "Data is the greatest currency created by the human race," Chris Stott, founder of Lonestar, said in an April 2022 statement. "We are dependent upon it for nearly everything we do and it is too important to us as a species to store in Earth's ever more fragile biosphere. Earth's largest satellite, our Moon, represents the ideal place to safely store our future."

In December 2021, Lonestar successfully ran a test of its data center on board the International Space Station. The company is now ready to launch a small data center box to the lunar surface later this year as part of Intuitive Machines's second lunar mission, IM-2 (the company's first mission, IM-1, is expected to launch in June). Intuitive Machines is receiving funding from NASA's Commercial Lunar Payload Services program for delivering research projects to the Moon as part of the space agency's Artemis program. The lunar data centers will initially be geared towards remote data storage and disaster recovery, allowing companies to back up their data and store it on the Moon. In addition, the data centers could assist with both commercial and private ventures to the lunar environment.

The miniature data center weighs about 2 pounds (1 kilogram) and has a capacity of 16 terabytes, Stott told SpaceNews. He said the first data center will draw power and communications from the lander, but the ones that will follow (pending its success) will be standalone data centers that the company hopes to deploy on the lunar surface by 2026. The test is only supposed to last for the duration of the IM-2 mission, which is expected to be around 11-14 days, an Intuitive Machines spokesperson told SpaceNews.

An anonymous reader quotes a report from The Guardian: More than 1,000 "super-emitter" sites gushed the potent greenhouse gas methane into the global atmosphere in 2022, the Guardian can reveal, mostly from oil and gas facilities. The worst single leak spewed the pollution at a rate equivalent to 67m running cars. Separate data also reveals 55 "methane bombs" around the world -- fossil fuel extraction sites where gas leaks alone from future production would release levels of methane equivalent to 30 years of all US greenhouse gas emissions.

Methane emissions cause 25% of global heating today and there has been a "scary" surge since 2007, according to scientists. This acceleration may be the biggest threat to keeping below 1.5C of global heating and seriously risks triggering catastrophic climate tipping points, researchers say. The two new datasets identify the sites most critical to preventing methane-driven disaster, as tackling leaks from fossil fuel sites is the fastest and cheapest way to slash methane emissions. Some leaks are deliberate, venting the unwanted gas released from underground while drilling for oil into the air, and some are accidental, from badly maintained or poorly regulated equipment.

Fast action would dramatically slow global heating as methane is short-lived in the atmosphere. An emissions cut of 45% by 2030, which the UN says is possible, would prevent 0.3C of temperature rise. Methane emissions therefore present both a grave threat to humanity, but also a golden opportunity to decisively act on the climate crisis. [...] The methane super-emitter sites were detected by analysis of satellite data, with the US, Russia and Turkmenistan responsible for the largest number from fossil fuel facilities. The biggest event was a leak of 427 tonnes an hour in August, near Turkmenistan's Caspian coast and a major pipeline. That single leak was equivalent to the rate of emissions from 67m cars, or the hourly national emissions of France. Future methane emissions from fossil fuel sites -- the methane bombs -- are also forecast to be huge, threatening the entire global "carbon budget" limit required to keep heating below 1.5C. More than half of these fields are already in production, including the three biggest methane bombs, which are all in North America.