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Science

Human Taste Buds Can Tell the Difference Between Normal and 'Heavy' Water, Study Finds (sciencealert.com) 104

An anonymous reader quotes a report from ScienceAlert: [T]here's been a longstanding question over whether heavy water tastes the same as regular drinking water -- or whether its subtle isotopic variation yields a different taste that people may be able to perceive. "There is anecdotal evidence from the 1930s that the taste of pure D2O is distinct from the neutral one of pure H2O, being described mostly as 'sweet,'" an international team of researchers led by first authors and biochemists Natalie Ben Abu and Philip E. Mason explains in a new study. [I]n their new research, Ben Abu, Mason, and their team can finally confirm that there really is something a bit different about the taste of heavy water. "Despite the fact that the two isotopes are nominally chemically identical, we have shown conclusively that humans can distinguish by taste (which is based on chemical sensing) between H2O and D2O, with the latter having a distinct sweet taste," explains senior author and physical chemist Pavel Jungwirth from the Czech Academy of Sciences.

In a taste-testing experiment with 28 participants, most people were able to distinguish between H2O and D2O, and tests with mixed amounts of the waters revealed that greater proportions of heavy water were perceived as tasting sweeter. In tests with mice, however, the animals did not seem to prefer drinking heavy water over regular water, although they did show a preference for sugared water -- suggesting that in mice, D2O does not elicit the same sweet taste that people can perceive. Other taste tests conducted by the team suggest why this is so, indicating that human taste receptivity to D2O is mediated by the taste receptor TAS1R2/TAS1R3, which is known to respond to sweetness in both natural sugars and artificial sweeteners. Experiments in the lab with HEK 293 cells confirmed the same thing, showing robust responses in TAS1R2/TAS1R3 expressing cells when exposed to D2O.
The findings are published in the journal Communications Biology.
Space

Remembering Yuri Gagarin, the First Man in Space (space.com) 97

Sixty years ago today, Yuri Gagarin became the first human ever in space.

Space.com reports: Because no one was certain how weightlessness would affect a pilot, the spherical capsule had little in the way of onboard controls; the work was done either automatically or from the ground. If an emergency arose, Gagarin was supposed to receive an override code that would allow him to take manual control, but Sergei Korolev, chief designer of the Soviet space program, disregarded protocol and gave the code to the pilot prior to the flight.

Over the course of 108 minutes, Vostok 1 traveled around the Earth once, reaching a maximum height of 203 miles (327 kilometers). The spacecraft carried 10 days' worth of provisions in case the engines failed and Gagarin was required to wait for the orbit to naturally decay. But the supplies were unnecessary. Gagarin re-entered Earth's atmosphere, managing to maintain consciousness as he experienced forces up to eight times the pull of gravity during his descent.

The BBC remembers how on his return to earth, Gagarin parachuted into some farmland several hundred miles from Moscow — "much to the surprise of a five-year-old girl who was out in the fields planting potatoes."

60 years later, the BBC tracked down and interviewed Interviewed that woman — who still remembered Gagarin's kind voice and smile. (Thanks to Slashdot reader 4wdloop for sharing the article.)

The BBC also published a look at Gagarin's global fame in the years that followed — and Phys.org notes that even today, there are few people more universally admired in Russia than Yuri Gagarin: His smiling face adorns murals across the country. He stands, arms at his sides as if zooming into space, on a pedestal 42.5 metres (140 feet) above the traffic flowing on Moscow's Leninsky Avenue. He is even a favourite subject of tattoos... The anniversary of Gagarin's historic flight on April 12, 1961 — celebrated every year in Russia as Cosmonautics Day — sees Russians of all ages lay flowers at monuments to his accomplishment across the country...

Gagarin, says historian Alexander Zheleznyakov, was a figure who helped fuel the imagination. "He transformed us from a simple biological species to one that could imagine an entire universe beyond Earth."

Biotech

How a Researcher 'Clinging To the Fringes of Academia' Helped Develop a Covid-19 Vaccine (nytimes.com) 64

Long-time Slashdot reader destinyland writes: The New York Times tells the story of Hungarian-born Dr. Kariko, whose father was a butcher and who growing up had never met a scientist — but knew they wanted to be one. Despite earning a Ph.D. at Hungary's University of Szeged and working as a postdoctoral fellow at its Biological Research Center, Kariko never found a permanent position after moving to the U.S., "instead clinging to the fringes of academia."

Now 66 years old, Dr. Kariko is suddenly being hailed as "one of the heroes of Covid-19 vaccine development," after spending an entire career focused on mRNA, "convinced mRNA could be used to instruct cells to make their own medicines, including vaccines."

From the article: For many years her career at the University of Pennsylvania was fragile. She migrated from lab to lab, relying on one senior scientist after another to take her in. She never made more than $60,000 a year... She needed grants to pursue ideas that seemed wild and fanciful. She did not get them, even as more mundane research was rewarded. "When your idea is against the conventional wisdom that makes sense to the star chamber, it is very hard to break out," said Dr. David Langer, a neurosurgeon who has worked with Dr. Kariko... Kariko's husband, Bela Francia, manager of an apartment complex, once calculated that her endless workdays meant she was earning about a dollar an hour.
The Times also describes a formative experience in 1989 with cardiologist Elliot Barnathan: One fateful day, the two scientists hovered over a dot-matrix printer in a narrow room at the end of a long hall. A gamma counter, needed to track the radioactive molecule, was attached to a printer. It began to spew data.

Their detector had found new proteins produced by cells that were never supposed to make them — suggesting that mRNA could be used to direct any cell to make any protein, at will.

"I felt like a god," Dr. Kariko recalled.

Yet Kariko was eventually left without a lab or funds for research, until a chance meeting at a photocopying machine led to a partnership with Dr. Drew Weissman of the University of Pennsylvania: "We both started writing grants," Dr. Weissman said. "We didn't get most of them. People were not interested in mRNA. The people who reviewed the grants said mRNA will not be a good therapeutic, so don't bother.'" Leading scientific journals rejected their work. When the research finally was published, in Immunity, it got little attention... "We talked to pharmaceutical companies and venture capitalists. No one cared," Dr. Weissman said. "We were screaming a lot, but no one would listen."

Eventually, though, two biotech companies took notice of the work: Moderna, in the United States, and BioNTech, in Germany. Pfizer partnered with BioNTech, and the two now help fund Dr. Weissman's lab.

Space

Astronomers Detect a Bright-Blue Bridge of Stars, and It's About To Blow (livescience.com) 28

"Astrophysicists have found a new region of the Milky Way, and it's filled with searingly hot, bright-blue stars that are about to explode," writes Live Science (in a report shared by long-time Slashdot reader fahrbot-bot): The researchers were creating the most detailed map yet of the star-flecked spiral arms of our galactic neighborhood with the European Space Agency's (ESA) Gaia telescope when they discovered the region, which they have named the Cepheus spur, they reported in a new study.

Nestled between the Orion Arm — where our solar system is — and the constellation Perseus, the spur is a belt between two spiral arms filled with enormous stars three times the size of the sun and colored blue by their blistering heat. Astronomers call these giant, blue stars OB stars due to the predominantly blue wavelengths of light that they emit. They are the rarest, hottest, shortest-living and largest stars in the entire galaxy. The violent nuclear reactions taking place inside their hearts make them six times hotter than the sun. And the enormous stellar explosions that end their lives — called supernovas — scatter the heavy elements essential for complex life far into the galaxy.

"OB stars are rare, in a Galaxy of 400 billion stars there might be less than 200,000," study co-author Michelangelo Pantaleoni González, a researcher at the Spanish Astrobiology Center (CAB), told Live Science.

Mars

NASA's Mars Helicopter Flight Postponed to No Earlier than This Wednesday (nasa.gov) 16

An anonymous reader shares this announcement from NASA: Based on data from the Ingenuity Mars helicopter that arrived late Friday night, NASA has chosen to reschedule the Ingenuity Mars Helicopter's first experimental flight to no earlier than April 14 [this Wednesday].

During a high-speed spin test of the rotors on Friday, the command sequence controlling the test ended early due to a "watchdog" timer expiration. This occurred as it was trying to transition the flight computer from 'Pre-Flight' to 'Flight' mode. The helicopter is safe and healthy and communicated its full telemetry set to Earth.

The watchdog timer oversees the command sequence and alerts the system to any potential issues. It helps the system stay safe by not proceeding if an issue is observed and worked as planned.

The helicopter team is reviewing telemetry to diagnose and understand the issue. Following that, they will reschedule the full-speed test.

Earth

Melting Ice Sheets Triggered 60 Feet of Sea Level Rise 14,600 Years Ago (phys.org) 100

"New research has found that previous ice loss events could have caused sea-level rise at rates of around 3.6 meters per century, offering vital clues as to what lies ahead should climate change continue unabated," reports Phys.org: A team of scientists, led by researchers from Durham University, used geological records of past sea levels to shed light on the ice sheets responsible for a rapid pulse of sea-level rise in Earth's recent past. Geological records tell us that, at the end of the last ice age around 14,600 years ago, sea levels rose at ten times the current rate due to Meltwater Pulse 1A (MWP-1A); a 500 year, ~18 meter sea-level rise event... The new study uses detailed geological sea-level data and state-of-the-art modelling techniques to reveal the sources... Interestingly, most of the meltwater appears to have originated from the former North American and Eurasian ice sheets, with minimal contribution from Antarctica, reconciling formerly disparate views...

The results are important for our understanding of ice-ocean-climate interactions which play a significant role in shaping terrestrial weather patterns. The findings are particularly timely with the Greenland ice sheet rapidly melting, contributing to a rise in sea levels and changes to global ocean circulation... Lead author Yucheng Lin, in the Department of Geography at Durham University notes, "The next big question is to work out what triggered the ice melt, and what impact the massive influx of meltwater had on ocean currents in the North Atlantic. This is very much on our minds today — any disruption to the Gulf Stream, for example due to melting of the Greenland Ice Sheet, will have significant consequences for the UK climate."

Biotech

Scientists Connect Human Brain To Computer Wirelessly For First Time Ever (thenextweb.com) 18

"Scientists have demonstrated the first human use of a wireless brain-computer interface, a potential breakthrough for people with paralysis," reports The Next Web (in a story shared by Slashdot reader Hmmmmmm): While traditional BCIs are tethered to users via cables, the new system — called BrainGate — replaces the cords with a small transmitter affixed atop a users' head. The unit then connects to an electrode array implanted in the brain's motor cortex. In a clinical trial, two participants with paralysis used the system to point, click, and type on a standard tablet computer. They both achieved similar typing speeds and point-and-click accuracy as those attained with wired systems.

The researchers say it's the first time a device has transmitted the full spectrum of signals recorded by a sensor in the brain's motor cortex.

Science

Scientists Dive Into Axolotl Genome, Looking For Secrets To Regeneration (gizmodo.com) 24

An anonymous reader quotes a report from Gizmodo: Its adorableness aside, the Mexican axolotl is a salamander of particular interest to scientists. On the molecular level, the animal seems to have a cheat code for life: It can regenerate its limbs and vital organs, an ability researchers are desperate to better understand for medical applications. Now, geneticists have gotten a clearer view of the smiling salamander's genome, rendering it on the chromosomal scale. The research was published this week in the Proceedings of the National Academy of Sciences. Understanding a genetic structure in complete detail takes a lot of time, far longer than it takes to first report the mapping of a genome, as we did with humans in 2003 and the duck-billed platypus in 2008. Secrets remain shrouded in those purportedly finished genetic codes, so geneticists keep tinkering. Decrypting the axolotl's genome in particular was a tall order; where bits of a human genome charged with making a protein may span hundreds to thousands of base pairs, in an axolotl, it takes hundreds of thousands of base pairs. Nevertheless, the complete axolotl genome was announced in 2019 by the same team who published the recent research.

The recent paper specifically looked at how the genome is folded away inside the animal on the molecular level and where the DNA sequences that regulate genes are located in relation to the places where gene transcription starts. That's remarkable when you consider the scale and extreme compactness of the folding; a human DNA strand is about 6 feet when stretched out, but an axolotl's would be over 30 feet. All that genetic material is being sequestered in the cells of an animal 200 times smaller than the average human -- it's a mind-boggling example of efficiency in packing, all on a microscopic scale.
Why it matters: The research will be important for seeing if the ability to regenerate could ever be activated in humans.

"The work has ordered the sequenced pieces of axolotl genomic DNA sequence in the correct order, as it is on the chromosome," Elly Tanaka, a biochemist at the Vienna BioCenter's Institute of Molecular Pathology, said in an email. "This is important because, in all animals with vertebrae, genes are turned on and off by control sequences that are actually lying pretty far away from the gene itself."
Science

Glass Molded Like Plastic Could Usher In New Era of Complex Glass Shapes (sciencemag.org) 41

sciencehabit shares a report from Science Magazine: The production of glass -- one of humanity's oldest materials -- is getting a 21st century makeover. A new approach to glassmaking treats the material like plastic, allowing scientists to injection mold vaccine vials, sinuous channels for carrying out lab chemistry, and other complex shapes.

The scientists created a printable powder by mixing silica nanoparticles with a polymer that could be cured with ultraviolet (UV) light. After printing the shapes they wanted, they cured the polymer with UV light so it would hold its shape. They then fired the mix in an oven to burn off the polymer and fuse the silica particles into a continuous glass structure. The approach worked, making it possible to craft shapes such as tiny pretzels and replica castle gates. The work garnered interest from companies wanting to build minute lenses and other complex transparent optical components for telecommunications equipment. But the procedure was slow, turning out components one by one, rather than a fully industrial approach that could produce parts en masse, as is done with plastic.

To speed things up, [the researchers] have now extended their nanocomposite approach to work with injection molding, a process used to mass produce plastic parts like toys and car bumpers by the ton. The researchers again started with tiny silica particles. The team then mixed the silica with two polymers, polyethylene glycol (PEG) and polyvinyl butyral (PVB). The mixture created a dry powder with the consistency of toothpaste. The team fed the paste into an extruder that pressed it into a preformed mold with shapes such as a disc or tiny gear. To harden them, the researchers used water to wash away the PEG. They then fired the remaining material in two stages: First at 600C to burn out the PVB, and second at 1300C to fuse the silica particles into the final piece. Outside of the mold, the parts hold their shape because myriad weak attractive bonds, called van der Waals interactions, form between neighboring silica particles. But the parts are still fragile.
The report has been published in the journal Science.
Science

New, Reversible CRISPR Method Can Control Gene Expression While Leaving DNA Sequence Unchanged (phys.org) 20

fahrbot-bot shares a report from Phys.Org: Over the past decade, the CRISPR-Cas9 gene editing system has revolutionized genetic engineering, allowing scientists to make targeted changes to organisms' DNA. While the system could potentially be useful in treating a variety of diseases, CRISPR-Cas9 editing involves cutting DNA strands, leading to permanent changes to the cell's genetic material. Now, in a paper published online in Cell on April 9, researchers describe a new gene editing technology called CRISPRoff that allows researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged.

The classic CRISPR-Cas9 system uses a DNA-cutting protein called Cas9 found in bacterial immune systems. The system can be targeted to specific genes in human cells using a single guide RNA, where the Cas9 proteins create tiny breaks in the DNA strand. Then the cell's existing repair machinery patches up the holes. Because these methods alter the underlying DNA sequence, they are permanent.

That's where the researchers saw an opportunity for a different kind of gene editor -- one that didn't alter the DNA sequences themselves, but changed the way they were read in the cell. This sort of modification is what scientists call 'epigenetic' -- genes may be silenced or activated based on chemical changes to the DNA strand. Epigenetic gene silencing often works through methylation -- the addition of chemical tags to to certain places in the DNA strand -- which causes the DNA to become inaccessible to RNA polymerase, the enzyme which reads the genetic information in the DNA sequence into messenger RNA transcripts, which can ultimately be the blueprints for proteins. With this new CRISPRoff technology, one can [express a protein briefly] to write a program that's remembered and carried out indefinitely by the cell.

Science

Are You Confused by Scientific Jargon? So Are Scientists (nytimes.com) 53

Scientific papers containing lots of specialized terminology are less likely to be cited by other researchers. The New York Times reports: Polje, nappe, vuggy, psammite. Some scientists who study caves might not bat an eye, but for the rest of us, these terms might as well be ancient Greek. Specialized terminology isn't unique to the ivory tower -- just ask a baker about torting or an arborist about bracts, for example. But it's pervasive in academia, and now a team of researchers has analyzed jargon in a set of over 21,000 scientific manuscripts. They found that papers containing higher proportions of jargon in their titles and abstracts were cited less frequently by other researchers. Science communication -- with the public but also among scientists -- suffers when a research paper is packed with too much specialized terminology, the team concluded. These results were published Wednesday in Proceedings of the Royal Society B.

Jargon can be a problem, but it also serves a purpose, said Hillary Shulman, a communications scientist at Ohio State University. "As our ideas become more refined, it makes sense that our concepts do too." This language-within-a-language can be a timesaver, a way to precisely convey meaning, she said. However, it also runs the risk of starkly reminding people -- even some well-educated researchers -- that they aren't "in the know." "It's alienating," said Dr. Shulman.

Science

Studies That Add Human Cells To Animal Brains Are Ethical, Panel Says (sciencemag.org) 50

sciencehabit shares a report from Science Magazine: Experiments that create tiny brainlike structures from human stem cells or transplant human cells into an animal's brain have made some scientists, ethicists, and religious leaders uneasy in recent years. And the National Institutes of Health (NIH) has restricted some of this research. Now, a U.S. scientific panel has weighed in with advice about how to oversee this controversial and fast-moving area of neuroscience. The panel finds little evidence that brain "organoids" or animals given human cells experience humanlike consciousness or pain, and concludes current rules are adequate for overseeing this work. But they caution that could change, particularly as experiments move into nonhuman primates. "The rationale for the report is to get out ahead of the curve," says Harvard University neuroscientist Joshua Sanes, co-chair of the National Academies of Sciences, Engineering, and Medicine committee that released its report today.
Science

Ant Responses To Social Isolation Resemble Those of Humans (phys.org) 26

An anonymous reader quotes a report from Phys.Org: Ants react to social isolation in a similar way as do humans and other social mammals. A study by an Israeli-German research team has revealed alterations to the social and hygienic behavior of ants that had been isolated from their group. The research team was particularly surprised by the fact that immune and stress genes were downregulated in the brains of the isolated ants. [...] While the effects of isolation have been extensively studied in social mammals such as humans and mice, less is known about how social insects respond in comparable situations -- even though they live in highly evolved social systems. Ants, for instance, live their entire lives as members of the same colony and are dependent on their colony mates. The worker ants relinquish their own reproductive potential and devote themselves to feeding the larvae, cleaning and defending the nest, and searching for food, while the queen does little more than just lay eggs.

The research team looked at the consequences of social isolation in the case of ants of the species Temnothorax nylanderi. These ants inhabit cavities in acorns and sticks on the ground in European forests, forming colonies of a few dozen workers. Young workers engaged in brood care were taken singly from 14 colonies and kept in isolation for varying lengths of time, from one hour to a maximum of 28 days. The study was conducted between January and March 2019 and highlighted three particular aspects in which changes were observed. After the end of their isolation, the workers were less interested in their adult colony mates, but the length of time they spent in brood contact increased; they also spent less time grooming themselves. [...] While the study revealed significant changes in the behaviors of the isolated insects, its findings with regard to gene activity were even more striking: Many genes related to immune system function and stress response were downregulated. In other words, these genes were less active. "This finding is consistent with studies on other social animals that demonstrated a weakening of the immune system after isolation," said Professor Inon Scharf.
The study has been published in the journal Molecular Ecology.
Math

Adding Is Favored Over Subtracting In Problem Solving (nature.com) 90

A series of problem-solving experiments reveal that people are more likely to consider solutions that add features than solutions that remove them, even when removing features is more efficient. Nature reports: Across a series of [...] experiments, the authors observe that people consistently consider changes that add components over those that subtract them -- a tendency that has broad implications for everyday decision-making. For example, Adams et al. and colleagues analyzed archival data and observed that, when an incoming university president requested suggestions for changes that would allow the university to better serve its students and community, only 11% of the responses involved removing an existing regulation, practice or program. Similarly, when the authors asked study participants to make a 10 x 10 grid of green and white boxes symmetrical, participants often added green boxes to the emptier half of the grid rather than removing them from the fuller half, even when doing the latter would have been more efficient.

Adams et al. demonstrated that the reason their participants offered so few subtractive solutions is not because they didn't recognize the value of those solutions, but because they failed to consider them. Indeed, when instructions explicitly mentioned the possibility of subtractive solutions, or when participants had more opportunity to think or practice, the likelihood of offering subtractive solutions increased. It thus seems that people are prone to apply a 'what can we add here?' heuristic (a default strategy to simplify and speed up decision-making). This heuristic can be overcome by exerting extra cognitive effort to consider other, less-intuitive solutions.

Biotech

Impossible Foods In Talks To Go Public (reuters.com) 47

According to Reuters, Impossible Foods is preparing for a public listing which could value the U.S. plant-based burger maker at around $10 billion or more. From the report: This would be substantially more than the $4 billion the company was worth in a private funding round in 2020. It would highlight growing demand for plant-based meat products, driven by environmental and ethical concerns among consumers. Impossible Foods is exploring going public through an initial public offering (IPO) in the next 12 months or a merger with a so-called special purpose acquisition company (SPAC), the sources said.

The Redwood City, California-based company has worked with a financial adviser to help manage discussions with SPACs after receiving offers at a lucrative valuation, the sources said. Going public through a SPAC could dilute existing Impossible Foods shareholders, however, by a greater extent than an IPO, the sources added. The sources, who requested because the discussions are private, cautioned that the deliberations are subject to market conditions and the company may opt to pursue another private fundraising round.

Movies

Elon Musk's Neuralink Co-Founder Says He Could Build the Real 'Jurassic Park,' With Genetically Engineered Dinosaurs (thehill.com) 71

The co-founder of Elon Musk's company Neuralink tweeted on Saturday that the startup has the technological advances and savvy to create its own "Jurassic Park." The Hill reports: "We could probably build Jurassic Park if we wanted to," Max Hodak tweeted Saturday. "Wouldn't be genetically authentic dinosaurs but [shrugging emoji]. maybe 15 years of breeding + engineering to get super exotic novel species." Hodak didn't further explain what technology Neuralink could use to engineer the long-extinct dinosaurs. It's worth noting that the tweet makes no mention of Neuralink, although one could presume Hodak is referring to the neurotechnology company because of his use of the word "we."

In response to the statement, which has been picked up by a variety of publications Wednesday, CNET's Jackson Ryan says we shouldn't expect a "real Jurassic Park" anytime soon -- or ever: [I]t's pretty much impossible to resurrect a dinosaur. The science of bringing dinosaurs back from the dead isn't really as sound as Hodak makes it seem though. Even humanity would have a tough time building a Jurassic Park in the next 15 years. First, we'd need some DNA from the prehistoric tyrants and unlike in the film Jurassic Park, where the DNA is retrieved from mosquitoes in amber and fused with frog DNA, that information has completely degraded.

However, more recently extinct animals, like the woolly mammoth, may be a good target for "de-extinction." We can still extract DNA from these creatures and could theoretically build and implant a mammoth embryo in a modern-day elephant. The question is: should we? Jurassic Park offers a pretty good reason not to, but mammoths aren't quite as bloodthirsty as Tyrannosaurus rex.

Biotech

NBA Partners With Biometric Screening Company To Allow Full Capacity Arenas Next Season 68

The NBA expects all arenas to be at full capacity next season, thanks to increased COVID-19 testing and more vaccines being administered. Another key aspect toward that effort is the NBA's new multiyear leaguewide partnership with Clear, a biometric screening company known for its expedited security process at hundreds of airports worldwide. ESPN reports: The partnership makes Clear's COVID-19 health screening technology available to all 30 teams in their NBA arenas, and it's expected to help facilitate more fans returning to games, though it's up to each team how to use the technology. Conversations for a leaguewide partnership began in early September. This is Clear's first leaguewide partnership with a professional sports league, but the company has been working with teams in MLS, MLB, NHL and the NFL. Clear first rolled out this program in a leaguewide format with the NHL's bubble season across two cities in Canada last year.

As it pertains to attendance, fans can download the Clear app and upload an identifying document along with a selfie. To link their COVID-19 test results, fans log into their testing account through the app, and results will be linked to their health pass. Before entering the venue, fans can open the app, verify their identity with another selfie and then answer health survey questions. (There are also expected to be an unspecified number of Clear kiosks where fans receive a temperature check and scan their QR code.) Fans are issued a red or green notification depending on their COVID-related health information.
A Clear spokesperson noted that the arenas only receive information about whether a fan has passed the requirements for access and not any private health information from the individual. They said that the Clear program is scalable, and could facilitate thousands of fans entering arenas.
Medicine

With Virus Origins Still Obscure, WHO and Critics Look To Next Steps 227

The joint international and Chinese mission organized by the World Health Organization on the origins of Covid released its report last week suggesting that for almost every topic it covered, more study was needed. What kind of study and who will do it is the question. From a report: The report suggested pursuing multiple lines of inquiry, focused on the likely origin of the coronavirus in bats. It concluded that the most likely route to humans was through an intermediate animal, perhaps at a wildlife farm. Among future efforts could be surveys of blood banks to look for cases that could have appeared before December 2019 and tracking down potential animal sources of the virus in wildlife farms, the team proposed. Critics of the report have sought more consideration of the possibility that a laboratory incident in Wuhan could have led to the first human infection. A loosely organized group of scientists and others who have been meeting virtually to discuss the possibility of a lab leak released an open letter this week, detailing several ways to conduct a thorough investigation. It called for further action, arguing that "critical records and biological samples that could provide essential insights into pandemic origins remain inaccessible."

Much of the letter echoes an earlier release from the same group detailing what it saw as the failures of the W.H.O. mission. This second letter is more specific in the kind of future investigations it proposes. The group is seeking a new inquiry that would include biosecurity and biosafety experts, one that could involve the W.H.O. or a separate multination effort to set up a different process to explore the beginnings of the pandemic and its origins in China. Jamie Metzl, an author, senior fellow of the Atlantic Council, an international policy think tank and signer of the scientists' letter, said the renewed calls for a more thorough investigation reflected the need for greater monitoring of and restrictions on what viruses can be studied in labs around the world. "This is not about ganging up on China," Mr. Metzl said. Mr. Metzl's group was among those disappointed by the report issued last week, as it dismissed out of hand the possibility of a leak from the Wuhan Institute of Virology, calling it extremely unlikely.
Further reading: Data Withheld From WHO Team Probing COVID-19 Origins in China: Tedros.
Science

Particle Mystery Deepens, As Physicists Confirm That the Muon Is More Magnetic Than Predicted (sciencemag.org) 66

sciencehabit writes: A potential chink in physicists' understanding of fundamental particles and forces now looks more real. New measurements confirm a fleeting subatomic particle called the muon may be ever so slightly more magnetic than theory predicts, a team of more than 200 physicists reported this week. That small anomaly -- just 2.5 parts in 1 billion -- is a welcome threat to particle physicists' prevailing theory, the standard model, which has long explained pretty much everything they've seen at atom smashers and left them pining for something new to puzzle over. "Since the 1970s we've been looking for a crack in the standard model," says Alexey Petrov, a theorist at Wayne State University. "This may be it." But Sally Dawson, a theorist at Brookhaven National Laboratory, notes the result is still not definitive. "It does nothing for our understanding of physics other than to say we have to wait a little longer to see if it is real."

For decades, physicists have measured the magnetism of the muon, a heavier, unstable cousin of the electron, which behaves like a tiny bar magnet. They put muons in a vertical magnetic field that makes them twirl horizontally like little compass needles. The frequency at which the muons twirl reveals how magnetic they are, which in principle can point to new particles, even ones too massive to be blasted into existence at an atom smasher like Europe's Large Hadron Collider. That's because, thanks to quantum uncertainty, the muon sits amid a haze of other particles and antiparticles flitting in and out of existence. These "virtual" particles can't be observed directly, but they can affect the muon's properties. Quantum mechanics and Albert Einstein's theory of special relativity predict the muon should have a certain basic magnetism. Familiar standard model particles flitting about the muon increase that magnetism by about 0.1%. And unknown particles lurking in the vacuum could add another, unpredictable increment of change.
Further reading: Finding From Particle Research Could Rewrite Known Laws of Physics.
Mars

NASA's Mars Helicopter Survives First Cold Martian Night On Its Own (nasa.gov) 34

"NASA's Ingenuity Mars Helicopter has emerged from its first night on the surface of Mars," reports NASA's Jet Propulsion Laboratory. The Ingenuity Mars Helicopter was deployed from the belly of NASA's Perseverance rover on April 3rd. In the days to come, Ingenuity will be the first aircraft to attempt powered, controlled flight on another planet. From the report: Evening temperatures at Jezero Crater can plunge as low as minus 130 degrees Fahrenheit (minus 90 degrees Celsius), which can freeze and crack unprotected electrical components and damage the onboard batteries required for flight. "This is the first time that Ingenuity has been on its own on the surface of Mars," said MiMi Aung, Ingenuity project manager at NASA's Jet Propulsion Laboratory in Southern California. "But we now have confirmation that we have the right insulation, the right heaters, and enough energy in its battery to survive the cold night, which is a big win for the team. We're excited to continue to prepare Ingenuity for its first flight test."

To ensure the solar array atop the helicopter's rotors could begin getting sunlight as soon as possible, Perseverance was instructed to move away from Ingenuity shortly after deploying it. Until the helicopter put its four legs onto the Martian surface, Ingenuity remained attached to the belly of the rover, receiving power from Perseverance, which touched down at Jezero Crater on Feb. 18. The rover serves as a communications relay between Ingenuity and Earth, and it will use its suite of cameras to observe the flight characteristics of the solar-powered helicopter from "Van Zyl Overlook."

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