sciencehabit writes: It took just one virus to cripple the world's economy and kill millions of people; yet virologists estimate that trillions of still-unknown viruses exist, many of which might be lethal or have the potential to spark the next pandemic. Now, they have a new -- and very long -- list of possible suspects to interrogate. By sifting through unprecedented amounts of existing genomic data, scientists have uncovered more than 100,000 novel viruses, including nine coronaviruses and more than 300 related to the hepatitis Delta virus, which can cause liver failure. "It's a foundational piece of work," says J. Rodney Brister, a bioinformatician at the National Center for Biotechnology Information's National Library of Medicine who was not involved in the new study. The work expands the number of known viruses that use RNA instead of DNA for their genes by an order of magnitude. It also "demonstrates our outrageous lack of knowledge about this group of organisms," says disease ecologist Peter Daszak, president of the EcoHealth Alliance, a nonprofit research group in New York City that is raising money to launch a global survey of viruses. The work will also help launch so-called petabyte genomics -- the analyses of previously unfathomable quantities of DNA and RNA data.

That wasn't exactly what computational biologist Artem Babaian had in mind when he was in between jobs in early 2020. Instead, he was simply curious about how many coronaviruses -- aside from the virus that had just launched the COVID-19 pandemic -- could be found in sequences in existing genomic databases. So, he and independent supercomputing expert Jeff Taylor scoured cloud-based genomic data that had been deposited to a global sequence database and uploaded by the U.S. National Institutes of Health. As of now, the database contains 16 petabytes of archived sequences, which come from genetic surveys of everything from fugu fish to farm soils to the insides of human guts. (A database with a digital photo of every person in the United States would take up about the same amount of space.) The genomes of viruses infecting different organisms in these samples are also captured by sequencing, but they usually go undetected.

While mapping radio waves across the universe, astronomers happened upon a celestial object releasing giant bursts of energy -- and it's unlike anything they've ever seen before. From a report: The spinning space object, spotted in March 2018, beamed out radiation three times per hour. In those moments, it became the brightest source of radio waves viewable from Earth, acting like a celestial lighthouse. Astronomers think it might be a remnant of a collapsed star, either a dense neutron star or a dead white dwarf star, with a strong magnetic field -- or it could be something else entirely. A study on the discovery published Wednesday in the journal Nature. "This object was appearing and disappearing over a few hours during our observations," said lead study author Natasha Hurley-Walker, an astrophysicist at the Curtin University node of the International Centre for Radio Astronomy Research, in a statement. "That was completely unexpected. It was kind of spooky for an astronomer because there's nothing known in the sky that does that. And it's really quite close to us -- about 4,000 light-years away. It's in our galactic backyard."

Moderna gave its omicron-specific COVID-19 vaccine to the first participant in a clinical trial, the company announced Wednesday. The report comes a few days after Pfizer / BioNTech launched a trial of its shot targeting the fast-spreading variant. From a report: The announcement coincides with the release of data showing that the two-dose series of Moderna's original vaccine struggled to block the omicron variant of the virus, which has mutations that help it dodge those antibodies. A booster shot restored much of its ability to neutralize the virus -- and while that protection weakened over time, it still stuck around for at least six months. Still, Moderna CEO Stephane Bancel said in a statement that the omicron variant is enough of a threat that the company plans to move forward with the variant booster.

An anonymous reader quotes a report from The New York Times: African clawed frogs are masters of putting themselves back together, handily regenerating lost tails and hind limbs, when they are tadpoles. But these powers dim with maturity. Wait for an adult frog to regrow a lopped-off limb and you'll see only a tapered spike, more like a talon than a leg. Now, a group of scientists have found a way to harness the adult frog's own cells to regrow an imperfect but functional limb. The researchers placed a silicone cap laden with a mixture of regenerative drugs onto an amputation wound for 24 hours. Over the next 18 months, the frogs gradually regrew what was lost, forming a new leglike structure with nerves, muscles, bones and even toelike projections.

The researchers describe this approach, which builds on earlier research, in a paper published Wednesday in the journal Science Advances. The process could guide future research on limb regeneration in humans, but it will be challenging to replicate the results in mammals. "It was a total surprise," Nirosha Murugan, a researcher at Algoma University in Ontario, Canada, and an author of the paper, said of the complexity of the regrown limb. "I didn't think we would get the patterning that we did." "It's not a full limb that's regrown," said Kelly Tseng, a biologist studying regeneration at the University of Nevada, Las Vegas, who was not involved with the research. "But it's certainly a robust response." "It is particularly promising that only a daylong treatment can have such a positive effect on an adult animal," Can Aztekin, a researcher studying limb regeneration at the Swiss Federal Institute of Technology in Lausanne who was not involved with the research, wrote in an email.

The secret behind a record-breaking nuclear fusion experiment that spit out 10 quadrillion watts of power in a split second has been revealed: a "self-heating" -- or "burning" -- plasma of neutron-heavy hydrogen inside the fuel capsule used in the experiment, according to researchers. Live Science reports: Last year, scientists at the Lawrence Livermore National Laboratory in Northern California announced the record release of 1.3 megajoules of energy for 100 trillionths of a second at the National Ignition Facility (NIF), Live Science reported at the time. In two new research papers, NIF scientists show the achievement was due to the precision engineering of the tiny cavity and fuel capsule at the heart of the world's most powerful laser system, where the fusion took place.

Although the fuel capsule was only about a millimeter (0.04 inch) across, and the fusion reaction lasted only the briefest sliver of time, its output was equal to about 10% of all the energy from sunlight that hits Earth every instant, the researchers reported. The researchers said the reaction blasted out that much energy because the process of fusion itself heated the remaining fuel into a plasma hot enough to enable further fusion reactions. "A burning plasma is when heating from the fusion reactions becomes the dominant source of heating in the plasma, more than required to initiate or jump-start the fusion," Annie Kritcher, a physicist at the Lawrence Livermore National Laboratory (LLNL), told Live Science in an email. Kritcher is the lead author of a study published Jan. 26 in Nature Physics describing how the NIF was optimized to achieve the burning plasma, and the co-author of another study published in Nature the same day that details the first burning plasma experiments at NIF in 2020 and early 2021.

The two new studies describe burning plasma experiments conducted in the months before the 10 quadrillion watt reaction; those earlier experiments culminated in the production of 170 kilojoules of energy from a pellet of just 200 micrograms (0.000007 ounces) of hydrogen fuel -- around three times the energy output of any earlier experiments. It was achieved by carefully shaping both the fuel capsule -- a tiny spherical shell of polycarbonate diamond that enclosed the pellet -- and the cavity that contained it -- a small cylinder of depleted (not very radioactive) uranium lined with gold, known as a hohlraum. The new designs allowed the NIF lasers that heated the pellet to operate more efficiently within the hohlraum, and the hot shell of the capsule to rapidly expand outward while the fuel pellet "imploded" -- with the result that the fuel fused at such a high temperature that it heated other parts of the pellet into a plasma.

He Who Has No Name writes: In a synopsis posted Monday, John Hewitt at Phys.org points out some fairly unsettling implications of an ugly trick by Covid-19 (more formally, SARS-CoV-2) -- it wakes up latent viruses that we are born with in our DNA. A quick version for those not familiar with virology: retroviruses are a subclass of viruses that leave copies of their RNA in the host cell's DNA as part of their replication process, the reverse of the way most viruses replicate (that's where the 'retro' part comes from). Latent, inactive sequences of retroviral DNA make up more than 1% of the human genome. We're literally born with them in our genes. Now back to Covid's latest trick.

From the article: "Transposable elements, or jumping genes, are now known to be responsible for many human diseases. Keeping them repressed by methylation, RNA binding, or the attentions of the innate immune system is a full-time jump for cells. Last week, we reviewed the activation of one particular kind of transposable element, the Line-1 retrotransposons, in an ever-expanding host of neurodegenerative conditions. Retrotransposons derive from human endogenous retrovirus (HERVs) but typically have lost their signature long terminal repeat sequences at the beginning and ends of their genes. On Tuesday, a real zinger was dropped onto the medRxiv preprint server that could potentially explain many of the commonly observed pathogenic features of SARS-CoV-2. The authors provide solid evidence that the SARS-CoV-2 spike protein activates the envelope (ENV) protein encoded by HERV-W in blood cells, which is in turn directly responsible for many pathological features of the disease."

While this is all analysis of preprint research, the evidence and implied results are very much in line with other long-term effects from Covid infection, especially neurocognitive symptoms, known to long haul Covid patients as "brain fog." Given that other research is showing long haul Covid cognitive symptoms are more accurately detected by the cognitive function test specifically used for HIV-Associated Neurocognitive Disorder (HAND) compared to standard function tests, the implication of retroviral elements to the puzzle of PACS (Post-Acute Covid Symptoms, the official term now in use for long haul Covid) is disturbing. The good news: only about 20-30% of people infected with Covid appear to be susceptible. This is, however, conspicuously in line with other data analysis showing that about 1 in 4 Covid victims has PACS / long-haul symptoms after the acute infection stage...

Doctors have discovered an "antibody signature" that can help identify patients most at risk of developing long Covid, a condition where debilitating symptoms of the disease can persist for many months. From a report: Researchers at University hospital Zurich analysed blood from Covid patients and found that low levels of certain antibodies were more common in those who developed long Covid than in patients who swiftly recovered. When combined with the patient's age, details of their Covid symptoms and whether or not they had asthma, the antibody signature allowed doctors to predict whether people had a moderate, high or very high risk of developing long-term illness. "Overall, we think that our findings and identification of an immunoglobulin signature will help early identification of patients that are at increased risk of developing long Covid, which in turn will facilitate research, understanding and ultimately targeted treatments for long Covid," said Onur Boyman, a professor of immunology who led the research. The team studied 175 people who tested positive for Covid and 40 healthy volunteers who acted as a control group. To see how their symptoms changed over time, doctors followed 134 of the Covid patients for up to a year after their initial infection. When Covid strikes, IgM antibodies ramp up rapidly, while IgG antibodies rise later and provide longer-term protection. Blood tests on the participants showed that those who developed long Covid -- also known as post-acute Covid-19 syndrome (Pacs) -- tended to have low levels of IgM and the antibody IgG3.

Long-time Slashdot reader shoor shares a report from Ars Technica: The refreshing kombucha tea that's all the rage these days among certain global demographics might also hold the key to affordable, environmentally sustainable living membranes for water filtration, according to a recent paper published in the American Chemical Society journal ACS ES&T Water. Experiments by researchers at Montana Technological University (MTU) and Arizona State University (ASU) showed that membranes grown from kombucha cultures were better at preventing the formation of biofilms -- a significant challenge in water filtration -- than current commercial membranes.

Co-author Katherine Zodrow, an environmental engineer at MTU, led an earlier 2020 study demonstrating the feasibility of making sustainable living filtration membranes (LFMs) out of a bacterial cellulose network and the native microorganisms of a kombucha SCOBY (symbiotic culture of bacteria and yeast) culture. Zodrow and her new collaborators made their membranes for this latest round of experiments the same way: by placing a SCOBY in a growth solution of sugar, black tea, and distilled white vinegar dissolved in deionized water. The researchers then placed the mixture in a temperature-controlled room for 10-12 days until a thick membrane formed on the mixture's surface. The grown membranes were stored in deionized water and used in experiments within eight days. The 20 liters of raw water samples for the experiments were taken from the three drinking water treatment plants in Butte, Montana: Basin Creek Reservoir, Moulton Reservoir, and Big Hole River. The water samples were then pretreated in accordance with standard practices at each plant.

Both the LFMs and polymer-based filters, the researchers discovered, became clogged over time, causing them to flow and filter more slowly. The LFMs used in the experiments, however, showed between 19 and 40 percent better performance than their commercial counterparts on that score. The SCOBY-based LFMs were also more resistant to befouling. While biofilms eventually formed, fewer microorganisms were found in those films. Zodrow et al. sequenced the DNA of any bacteria and fungi in the SCOBY-based membrane and found that 97 percent of the bacteria present belonged to the genus Acetobacter. This is not surprising, since it's also the dominant bacteria in kombucha, but it may explain why the LFMs performed so well with regard to biofilms. As the name implies, a defining characteristic of this genus is the ability to oxidize organic carbon sources like sucrose, glucose, and ethanol into acetic acid, which is known for its antimicrobial properties. Acetobacter has also been shown to reduce or even remove biofilms, in keeping with the results of Zodrow et al.'s experiments.

NASA has confirmed that the James Webb Space Telescope has successfully entered its final orbit around the second Sun-Earth Lagrange point after one last course correction burn. Engadget reports: The telescope's primary mirror segments and secondary mirror have already been deployed, but you'll have to wait until the summer for the first imagery. NASA will spend the next several months readying the JWST for service, including a three-month optics alignment process. The L2 orbit is crucial to the telescope's mission. It provides a largely unobstructed view of space while giving the spacecraft a cold, interference-free position that helps its instruments live up to their full potential. The JWST is expected to study the early Universe using infrared light, providing data that wouldn't be available from an Earth orbit telescope like Hubble.

An anonymous reader quotes a report from The Drive: Space Force launched two additional satellites today as part of its push for greater Space Domain Awareness, or SDA, in geosynchronous orbit some 22,000 miles away from Earth. The two satellites are part of the Geosynchronous Space Situational Awareness Program, or GSSAP, and will allow Space Force to not only locate and identify objects in this distant orbit, but also maneuver close to them in order to inspect them or assess their capabilities. The launch comes as Space Force leadership continues to sound the alarm about the risks posed to U.S. satellites in orbit.

The Northrop Grumman-built GSSAP-5 and GSSAP-6 were launched today at Cape Canaveral Space Force Station in Florida atop a United Launch Alliance (ULA) Atlas V 511 rocket. The first two GSSAP satellites were launched in 2014, with the second two following in 2016. Space Force has not released any details about how these two new GSSAP satellites might differ from the previous four, which were designed to operate near the belt of other geosynchronous satellites and maneuver close to them to conduct surveillance. A spokesperson for Space Systems Command stated this week that the new GGSAP satellites "will provide improved SDA data to the National Space Defense Center and other national users to enhance our ability to navigate freely and safely within the GEO belt."

GSSAP-5 and GSSAP-6 were originally scheduled to be launched in 2020, and it is not known why the launch was delayed almost two years. The GSSAP program was originally highly classified and was only revealed to the public in 2014. While the exact capabilities of the satellites are not public, it's known that they are able to capture close-up images of other satellites in geosynchronous orbit. Former Commander of Air Force Space Command Gen. William Shelton (Ret.) told Aviation Week in 2014 that the satellites are designed to drift in and out of the geosynchronous belt collecting intelligence on specific targets. The Air Force has previously used one of the satellites for Remote Proximity Operations (RPO), maneuvering close enough to inspect another Department of Defense satellite operated by the Navy that was experiencing a malfunction. The former head of Air Force Space Command, General John Hyten (Ret.), has previously said the satellites are capable of capturing some "truly eye-watering" imagery.

An anonymous reader shares a report: NASA's Spinoff magazine is one of the things I look forward to reading every year. The space agency's research trickles down to the rest of the world in surprising and interesting ways, which it tracks and collects in this annual publication. This year is no different, and NASA tech can be found in everything from hiking gadgets to heavy industry and, funnily enough, space. There are dozens of technologies that have made their way to everyday use in a variety of places highlighted in this year's issue, which you can browse here [PDF]. I talked with Daniel Lockney, the head of NASA's Tech Transfer Program overseeing the deployment of its tech and research among terrestrial companies looking to put it to good use. "Typically what happens is: NASA develops something, they report it to my office, and we look at it to figure out, first, does it work? And second, who else can use it? And if someone can, we figure out how to get it to them," Lockney explained. "I try to give as much away for free as I can. I've got no direction to generate revenue or bring something back to the U.S. treasury. The 1958 NASA act that created us says to disseminate our work -- nothing in there about making a dime."

The result is cheap or free licensing of interesting tech like compact, long-lasting water filters, unusual mechanical components, and other tech that was needed for space or launch purposes but might find a second use on the ground. Lockney highlighted a couple items in the latest batch that he thought were especially interesting. "There was a partnership with GM to develop the Robo-Glove, a functional glove that astronauts will wear to help reduce strain during repetitive tasks and increase grip strength," he said. "Squeezing something on a spacewalk, you can do it a couple times, but if you're gripping a tool for the whole afternoon... so we developed this glove to assist in that work, and now it's being used at factories around the world."

Mark Cuban's announcement over the weekend of an online pharmacy selling over a hundred generic drugs at near cost was totally unexpected but will likely be welcomed by millions who struggle to afford medication. The billionaire told TechCrunch that the business model is refreshingly simple: "Lower pricing reduces patient stress, and that will lead to more customers." From the report: The Cost Plus Drug Company aims very simply to provide as many common medications as possible in generic form at as low a price as possible. All cash, no IP deals, no insurance companies -- just buy pills for what they cost to make, plus 15 percent to cover overhead. Asked about ROI, Cuban admitted there isn't much to speak of, by design. "I want to be above break even while maximizing the number of people who can afford their medications," he said. "Shoot. I would be happy if we can make a little, but push pricing of generics sold elsewhere down significantly. Our challenge is to keep pushing prices lower," not compete with anyone, he continued. "Our KPI is how much we can reduce the stress of our patients who buy generic meds. When people save a lot of money on their medications, they often will tell others they know that have the same challenges. That word of mouth impacts our growth the most."

Friday the results of several large studies showed that getting a third Covid vaccine "booster shot" dramatically decreased infections from the Omicron variant.

And now the Times of Israel reports that the country's Health Ministry "said on Sunday that the fourth vaccine dose for those aged 60 and up offers a threefold protection against serious illness and twofold protection against infection in the current wave driven by the Omicron variant." The ministry said the figures are the result of initial analysis by experts from various leading academic and health institutions, and compares the fourth vaccine with those who received three doses at least four months ago.

The figures are based on 400,000 Israelis who received the fourth vaccine and 600,000 who received three doses, with the ministry stressing that the methodology is similar to previous papers the experts have published in the peer-reviewed New England Journal of Medicine.

CNET reports: Saturn has some famous moons, like Enceladus (a plume-spewing moon of mystery) and Titan (the intriguing target of NASA's future Dragonfly mission). But what about dainty Mimas, a moon that's mostly known for its resemblance to the Star Wars Death Star?

Turns out it might be hiding an ocean.

A study published in the journal Icarus lays out evidence that suggests Mimas has liquid deep under its icy surface. "If Mimas has an ocean, it represents a new class of small, 'stealth' ocean worlds with surfaces that do not betray the ocean's existence," said lead author Alyssa Rhoden in a Southwest Research Institute (SwRI) statement on Wednesday. Mimas might look quiet, but NASA's now-defunct Saturn-studying Cassini spacecraft "identified a curious libration, or oscillation, in the moon's rotation, which often points to a geologically active body able to support an internal ocean," SwRI said.

The libration spotted by Cassini suggests Mimas's interior is warm enough for a liquid ocean, but not so warm it compromises the moon's thick shell of ice.

The researchers calculate that ice shell could be up to 19 miles (31 kilometers) thick. There's a nifty acronym for interior water ocean worlds: IWOWs. Known IWOWs include Enceladus, Titan and Jupiter's fascinating moon Europa. These places are particularly interesting because they may be habitable for microbial life.

"If a rock falls on Mars, and no one is there to see it, does it leave a trace?" jokes the New York Times, answering "Yes, and it's a beautiful herringbone-like pattern, new research reveals." Scientists have now spotted thousands of tracks on the red planet created by tumbling boulders. Delicate chevron-shaped piles of Martian dust and sand frame the tracks, the team showed, and most fade over the course of a few years.

Rockfalls have been spotted elsewhere in the solar system, including on the moon and even a comet. But a big open question is the timing of these processes on other worlds — are they ongoing or did they predominantly occur in the past?A study of these ephemeral features on Mars, published last month in Geophysical Research Letters, says that such boulder tracks can be used to pinpoint recent seismic activity on the red planet. This new evidence that Mars is a dynamic world runs contrary to the notion that all of the planet's exciting geology happened much earlier, s aid Ingrid Daubar, a planetary scientist at Brown University who was not involved in the study...

To arrive at this finding, Vijayan, a planetary scientist at the Physical Research Laboratory in Ahmadabad, India, who uses a single name, and his colleagues pored over thousands of images of Mars' equatorial region. The imagery was captured from 2006 through 2020 by the High Resolution Imaging Science Experiment (HiRISE) camera onboard NASA's Mars Reconnaissance Orbiter and revealed details as small as 10 inches across. "We can discriminate individual boulders," Vijayan said. The team manually searched for chain-like features — a telltale signature of a rock careening down an incline — on the sloped walls of impact craters. Vijayan and his collaborators spotted more than 4,500 such boulder tracks, the longest of which stretched more than a mile and a half...

Roughly one-third of the tracks the researchers studied were absent in early images, meaning that they must have formed since 2006... The researchers suggest that winds continuously sweeping over the surface of Mars redistribute dust and sand and erase the ejecta. Because boulder fall ejecta fades so rapidly, seeing it implies that a boulder was dislodged recently, the team suggest. And a common cause of rockfalls, on Earth and elsewhere, is seismic activity.... Since 2019, hundreds of marsquakes have been detected by NASA's InSight lander, and two of the largest occurred last year in the Cerberus Fossae region.
Today the Mars lander InSight is back in operation after a two-week break to avoid dust storms, while dust storms also delayed the 19th flight of NASA's Ingenuity helicopter.

And elsewhere on Mars, the Perserverance rover successfully dislodged two pebbles stuck in its sample-collecting apparatus.

In 1992 John Conway raised a question about the patterns in his famous mathematical Game of Life: "Is there a Godlike still-life, one that can only have existed for all time (apart from things that don't interfere with it)?"

Conway closed his note by adding "Well, I'm going out to get a hot dog now..." And then, nearly 30 years later, a mathematical blog reports: Ilkka Törmä and Ville Salo, a pair of researchers at the University of Turku in Finland, have found a finite configuration in Conway's Game of Life such that, if it occurs within a universe at time T, it must have existed in that same position at time T-1 (and therefore, by induction, at time 0)...

The configuration was discovered by experimenting with finite patches of repeating 'agar' and using a SAT solver to check whether any of them possess this property.
The blogger also shares some other Game of Life-related news:

• David Raucci discovered the first oscillator of period 38. The remaining unsolved periods are 19, 34, and 41.
• Darren Li has connected Charity Engine to Catagolue, providing approximately 2000 CPU cores of continuous effort and searching slightly more than 10^12 random initial configurations per day.
• Nathaniel Johnston and Dave Greene have published a book on Conway's Game of Life, featuring both the theoretical aspects and engineering that's been accomplished in the half-century since its conception. Unfortunately it was released slightly too early to include the Törmä-Salo result or Raucci's period-38 oscillator.

Thanks to Slashdot reader joshuark for sharing the story.

"Scientists have estimated the number of 'small' black holes in the universe," reports Live Science. "And no surprise: It's a lot." Using a new method, outlined January 12 in The Astrophysical Journal, a team of astrophysicists has produced a fresh estimate for the number of stellar-mass black holes — those with masses 5 to 10 times that of the sun — in the universe.

And it's astonishing: 40,000,000,000,000,000,000, or 40 quintillion, stellar-mass black holes populate the observable universe, making up approximately 1% of all normal matter, according to the new estimate.

So how did the scientists arrive at that number? By tracking the evolution of stars in our universe they estimated how often the stars — either on their own, or paired into binary systems — would transform into black holes, said first author Alex Sicilia, an astrophysicist at the International School of Advanced Studies (SISSA) in Trieste, Italy. "This is one of the first, and one of the most robust, ab initio [ground up] computation[s] of the stellar black hole mass function across cosmic history," Sicilia said in a statement....

To arrive at their estimate, the astrophysicists modeled not just the lives, but the pre-lives of the universe's stars. Using known statistics of various galaxies, such as their sizes, the elements they contain, and the sizes of the gas clouds stars would form in, the team built a model of the universe that accurately reflected the different sizes of stars that would be made, and how often they would be created.... [T]he researchers designed a model that tracked the population and size distribution of stellar-mass black holes over time to give them their eye-watering number. Then, by comparing the estimate with data taken from gravitational waves, or ripples in space-time, formed by black hole and binary star mergers, the researchers confirmed that their model was in good agreement with the data.

Astrophysicists hope to use the new estimate to investigate some perplexing questions that arise from observations of the very early universe — for instance, how the early universe became so quickly populated by supermassive black holes — often with masses millions, or even billions, of times greater than the stellar-mass holes the researchers examined in this study — so soon after the Big Bang.

"Three studies released Friday offered more evidence that COVID-19 vaccines are standing up to the omicron variant, at least among people who received booster shots," reports the Associated Press: They are the first large U.S. studies to look at vaccine protection against omicron, health officials said. The papers echo previous research — including studies in Germany, South Africa and the U.K. — indicating available vaccines are less effective against omicron than earlier versions of the coronavirus, but also that boosters doses rev up virus-fighting antibodies to increase the chance of avoiding symptomatic infection.

The first study looked at hospitalizations and emergency room and urgent care center visits in 10 states, from August to this month. It found vaccine effectiveness was best after three doses of the Pfizer or Moderna vaccines in preventing COVID-19-associated emergency department and urgent care visits. Protection dropped from 94% during the delta wave to 82% during the omicron wave. Protection from just two doses was lower, especially if six months had passed since the second dose. Officials have stressed the goal of preventing not just infection but severe disease. On that count, some good news: A third dose was at least 90% effective at preventing hospitalizations for COVID-19, both during the delta and omicron periods, the study also found.

The second study focused on COVID-19 case and death rates in 25 states from the beginning of April through Christmas. People who were boosted had the highest protection against coronavirus infection, both during the time delta was dominant and also when omicron was taking over...

The Journal of the American Medical Association published the third study, also led by CDC researchers. It looked at people who tested positive for COVID-19 from Dec. 10 to Jan. 1 at more than 4,600 testing sites across the U.S. Three shots of the Pfizer and Moderna vaccines were about 67% effective against omicron-related symptomatic disease compared with unvaccinated people. Two doses, however, offered no significant protection against omicron when measured several months after completion of the original series, the researchers found.

MIT, Brigham, and Women's Hospital researchers are working to eliminate many of the headaches associated with treating diabetes. According to Engadget, "They're developing all-in-one devices that measure glucose, calculate the necessary insulin dose and inject you accordingly." From the report: The first device includes the blood-drawing lancet, glucose test strips and an insulin needle. Users would first take a photo of their meal using a smartphone app to estimate the food volume and carbohydrate levels. After that, they'd start the automated process of collecting blood, calculating glucose (again through the app) and delivering the appropriate amount of insulin. The second gadget would only need one needle jab -- it would build the glucose sensor into the insulin needle and inject the appropriate amount of insulin. You'd have to wait five to ten seconds, but you wouldn't have to stick yourself twice.

The technology is still some ways off. While the first device would use parts that were already FDA-approved, it hasn't been tested in humans. The second, meanwhile, uses a new sensor type that will likely require more work to be testable with humans. Scientists have filed patents for both devices and are hoping to work with companies on further development. There's a strong motivation to bring these devices to market, at least. People with diabetes would only need to use one device at meals, and with the hybrid sensor/needle might suffer less pain. That, in turn, could encourage consistent treatment that improves your overall wellbeing.

In 2021, there was an upsurge in peculiar sightings reported, thanks to people with smartphones or other video gear that captured these strange glimmers in the sky. In 2022, UAP will get more attention from both the scientific community and the federal government, experts told Space.com. From the report: One potential major development in 2022 will be UFO detection, according to Mark Rodeghier, scientific director of the Center for UFO Studies in Chicago. "The effort to detect, track and measure the UFO phenomenon in the field, in real time, has recently entered a new phase," Rodeghier told Space.com. "The technology has gotten better, software tools have improved and the current interest in UFOs has attracted new, qualified professionals. "While one can't predict how soon we will gain new, fundamental knowledge about UAP/UFOs, I believe that these efforts are very likely to succeed and set UFO research onto a new foundation of reliable, physical data," Rodeghier added. "And as a consequence, we will have even more evidence -- as if it was needed -- that the UFO phenomenon is real and can be studied scientifically."

One upcoming initiative, called the Galileo Project, will search for extraterrestrial equipment near Earth. It has two branches. The first aims to identify the nature of interstellar objects that do not resemble comets or asteroids -- like 'Oumuamua, the first known interstellar object to visit the solar system. The second branch targets UAP, similar to those of interest to the U.S. government. "The Galileo Project's data will be open to the public, and its scientific analysis will be transparent," said Harvard astronomer Avi Loeb, who is spearheading the project. "The related scientific findings would expand humanity's knowledge, with no attention to borders between nations." The Galileo research team includes more than 100 scientists who plan to assemble the project's first telescope system on the roof of the Harvard College Observatory in spring 2022. "The system will record continuous video and audio of the entire sky in the visible, infrared and radio bands, as well as track objects of interest," Loeb said. "Artificial intelligence algorithms will distinguish birds from drones, airplanes or something else. Once the first system will operate successfully, the Galileo Project will make copies of it and distribute them in many geographical locations."

Currently, there is a lack of coordination among organizations involved in UAP detection equipment, but that may change this year, said Robert Powell, an executive board member of the Scientific Coalition for UAP Studies (SCU) in Austin, Texas. "I believe that will improve as we go into 2022," he said. A number of SCU members are involved with the Galileo Project, and the organization has partnered with several groups, including UFODATA, the UFO Data Acquisition Project (UFODAP) and UAPx. "UFODAP already has a working model that has been sold into the marketplace and is reasonably priced in the $2,000 to $5,000 range, depending on the accessories desired," Powell told Space.com. "This system has already been used by a group known as UAPx to collect data. Our goal is to coordinate these activities in a way such that we use a system with standardized equipment set to collect data." But before that happens, Powell said, the groups need to plot out exactly what that equipment is trying to measure and verify that the system can achieve that goal.