Mars

NASA's Perseverance Mars Rover Has Made Oxygen 7 Times In Exploration Milestone (space.com) 72

Stefanie Waldek reports via Space.com: Led by the Massachusetts Institute of Technology (MIT), the Mars Oxygen In-Situ Resource Utilization Experiment (MOXIE) is a small instrument on the Perseverance rover that's designed to transform carbon dioxide, which comprises some 96% of the atmosphere on Mars, into breathable oxygen. Oxygen, of course, is crucial for a human mission to Mars. Since February 2021, the device has run seven times, each time producing about 0.2 ounces (6 grams) of oxygen per hour. That's on par with the abilities of small trees here on Earth.

MOXIE has now operated in a variety of conditions on Mars, both day and night, through all four seasons. The researchers expect that a version of the instrument approximately 100 times larger than MOXIE could potentially create breathable oxygen for future astronauts who visit the Red Planet. If explorers can't make their own oxygen on Mars, supplies from Earth would take up valuable mass on a spacecraft. Furthermore, MOXIE's products could also be used as an ingredient for rocket fuel -- pretty crucial to ensuring the mission isn't one-way. A rocket would need 33 to 50 tons (30 to 45 metric tons) of liquid oxygen propellant in order to launch humans off Mars.
"This is the first demonstration of actually using resources on the surface of another planetary body, and transforming them chemically into something that would be useful for a human mission," MOXIE deputy principal investigator Jeffrey Hoffman, a professor of the practice in MIT's Department of Aeronautics and Astronautics and a former NASA astronaut, said in a statement. "It's historic in that sense."

The research has been published in the journal Science Advances.
Science

Scientists Break the Direction of Time Down To the Cellular Level In Mind-Bending Study (vice.com) 73

A new study looks at interactions between microscopic neurons in salamanders to understand how the "arrow of time" is biologically generated. Motherboard reports: The second law of thermodynamics says that everything tends to move from order to disorder, a process known as entropy that defines the arrow of time. A stronger arrow of time means it would be harder for a system to go back to a more ordered state. "Everything that we perceive as a difference between the past and the future stems fundamentally from that one principle about the universe," said Christopher Lynn, the lead author of the study. Lynn said that his motivation for the study was "to understand how the arrows of time we see in life" fit into this larger idea of entropy on the scale of the entire universe.

Using previously done research on salamanders, Lynne and colleagues at City University of New York and Princeton examined how the arrow of time is represented in interactions between the amphibians' neurons in response to watching a movie. Their research is soon to be published in the journal Physical Review Letters. On one hand, it's somewhat obvious that an arrow of time would be biologically produced. "To be alive, almost, you have to have an arrow of time because you develop from a baby to an adult, and you're constantly moving and taking in stimuli," Lynne said. Indeed, entropy here is irreversible -- you cannot go back. What the team found was anything but intuitive, however.

Lynne and colleagues looked at a separate 2015 study where researchers had salamanders watch two different movies. One depicted a scene of fish swimming around, similar to what a salamander might experience in everyday life. As in the real world, the video had a clear arrow of time -- that is, if you watched it in reverse, it would look different than if you played it forwards. The other video contained only a gray screen with a black, horizontal bar in the middle of the screen, which moved quickly up and down in a random, jittery way. This video didn't have an obvious arrow of time. A major question for the researchers was if they could pick out signs of "local irreversibility" in interactions between small groups of retinal neurons in response to this stimulus. Would interactions with irreversibility -- they would look different if played in reverse, having an "arrow of time" -- present in simpler or more complex interactions between neurons? "You can go look at a system and you can ask: are the more complicated interactions strongly producing the arrow of time, or is it the simpler dynamics?" said Lynn.

The researchers found that the interactions between simple pairs of neurons primarily determined the arrow of time, no matter which movie the salamanders watched. In fact, the authors found a stronger arrow of time for the neurons when salamanders watched the video with the gray screen and black bar -- in other words, the video without an arrow of time in its content elicited a greater arrow of time in the neurons. "We naively thought that if the stimulus has a stronger arrow of time, that would show up on your retina," said Lynn. "But it was the opposite. So that's why it was surprising to us." While the researchers can't say for sure why this is, Lynn said that it might be because salamanders are more used to seeing something like the fish movie, and processing the more artificial movie took greater energy. In a more disordered system, which would have a greater arrow of time, more energy is consumed. "Being alive will still define an arrow of time," Lynne said, no matter the stimulus.

Earth

Scientists Call on Colleagues To Protest Climate Crisis With Civil Disobedience (theguardian.com) 146

Scientists should commit acts of civil disobedience to show the public how seriously they regard the threat posed by the climate crisis, a group of leading scientists has argued. From a report: "Civil disobedience by scientists has the potential to cut through the myriad complexities and confusion surrounding the climate crisis," the researchers wrote in an article, published in the scientific journal Nature Climate Change on Monday.

"When those with expertise and knowledge are willing to convey their concerns in a more uncompromising manner ... this affords them particular effectiveness as a communicative act. This is the insight of Greta Thunberg when she calls on us to âact as you would in a crisis.'" In recent months, scientists have shown themselves increasingly willing to take part in direct actions to bring attention to the climate crisis. A "scientists rebellion" mobilised more than 1,000 scientists in 25 countries in April, while in the UK a number of scientists were arrested for gluing scientific papers -- and their hands -- on to the glass facade of the Department for Business, Energy and Industrial Strategy.

Medicine

FDA Authorizes Updated Covid Booster Shots, Targeting Omicron Subvariants (nytimes.com) 189

The Food and Drug Administration on Wednesday authorized the first redesign of coronavirus vaccines since they were rolled out in late 2020, setting up millions of Americans to receive new booster doses targeting Omicron subvariants as soon as next week. From a report: The agency cleared two options aimed at the BA.5 variant of Omicron that is now dominant: one made by Pfizer and its German partner BioNTech for use in people as young as 12, and the other by Moderna, for those 18 and older. The doses can be given at least two months since people last received a booster dose or completed their initial series of vaccinations.

Biden administration officials have argued that even as researchers work to understand how protective the new shots might be, inoculating Americans again in the coming weeks could help curb the persistently high number of infections and deaths. "As we head into fall and begin to spend more time indoors, we strongly encourage anyone who is eligible to consider receiving a booster dose," Dr. Robert M. Califf, the F.D.A. commissioner, said in a statement on Wednesday. He added that the vaccine would "provide better protection against currently circulating variants."

NASA

Engineers Solve Data Glitch On NASA's Voyager 1 (nasa.gov) 60

A critical system aboard the probe was sending garbled data about its status. Engineers have fixed the issue but are still seeking the root cause. NASA reports: Engineers have repaired an issue affecting data from NASA's Voyager 1 spacecraft. Earlier this year, the probe's attitude articulation and control system (AACS), which keeps Voyager 1's antenna pointed at Earth, began sending garbled information about its health and activities to mission controllers, despite operating normally. The rest of the probe also appeared healthy as it continued to gather and return science data. The team has since located the source of the garbled information: The AACS had started sending the telemetry data through an onboard computer known to have stopped working years ago, and the computer corrupted the information.

Suzanne Dodd, Voyager's project manager, said that when they suspected this was the issue, they opted to try a low-risk solution: commanding the AACS to resume sending the data to the right computer. Engineers don't yet know why the AACS started routing telemetry data to the incorrect computer, but it likely received a faulty command generated by another onboard computer. If that's the case, it would indicate there is an issue somewhere else on the spacecraft. The team will continue to search for that underlying issue, but they don't think it is a threat to the long-term health of Voyager 1.

NASA

NASA Scrubs First Test Flight of Moon Rocket After Engine Fault (bloomberg.com) 90

NASA delayed the debut launch of its new massive rocket due to an issue with one of its engines, dealing a temporary blow to the space agency's plan to return to the lunar surface. From a report: With Vice President Kamala Harris in attendance at Florida's Kennedy Space Center and a global audience watching online, the uncrewed Artemis I mission was called off at 8:34 a.m., one minute after its originally scheduled liftoff time. The launch missed its window after controllers were unable to resolve a temperature problem with one of the rocket's four main engines. The rocket and space capsule are in "a safe and stable configuration," NASA said Monday in a statement, adding that engineers were continuing to gather data.

The earliest available opportunity to try again is on Sept. 2, NASA said in a webcast while announcing the scrubbed launch. No decision has been made on rescheduling. Official confirmation of the delay came after the space agency spent the early morning hours investigating issues including a potential crack in material in the main body of the rocket as well as the temperature issue, officials said earlier Monday. Those came after engineers examined and resolved a suspected leak affecting the hydrogen tanking process.

Science

Is There a Connection Between Life's Origin, Geothermal Vents, Cancer, and Aging? (quantamagazine.org) 59

Long-time Slashdot reader Beeftopia writes: All living cells power themselves by coaxing protons from one side of a membrane to the other. A place where this occurs naturally outside of cells are alkaline hydrothermal vents on the deep seafloor, inside highly porous rock formations that are almost like mineralized sponges. "Carbon and energy metabolism are driven by proton gradients, exactly what the vents provided for free," wrote biochemist Nick Lane. In Lane's view, metabolism came first, and genetic information emerged naturally from it rather than the other way around.
Quanta magazine asks Lane the big question: How did these first proto-cells become independent from the proton gradients they got for free in the hydrothermal vents? LANE: We've shown that theoretically, if you introduce random sequences of RNA and assume that the nucleotides in there can polymerize, you get little chains of nucleotides. Let's say seven or eight random letters long, with no information encoded in there whatsoever.... [H]ydrophobic amino acids are more likely to interact with hydrophobic bases. So you have a random sequence of RNA that generates a nonrandom peptide. And that nonrandom peptide could by chance have some function in a growing proto-cell. It could make the cell grow better or grow worse; it could help the RNA replicate itself; it could bind to cofactors. Then you have selection for that peptide and the RNA sequence that gave rise to it.

Although it's a very rudimentary system, this means we've just entered the world of genes, information and natural selection.

Quanta summarizes Lane's next idea: that these vent environments "favored the beginnings of what we call the Krebs cycle, the metabolic process that derives energy from carbohydrates, fats and proteins." Lane himself has said that metabolism "conjures genes into existence."

But if genes are conjured into existence by metabolism, then what else might be true? Lane ultimately concludes that cancer may be a metabolic disease rather than a "genomic" one: LANE: About 10 years ago, the cancer community was amazed by the discovery that in some cancers, mutations can lead to parts of the Krebs cycle running backward. It came as quite a shock because the Krebs cycle is usually taught as only spinning forward to generate energy. But it turns out that while a cancer cell does need energy, what it really needs even more is carbon-based building blocks for growth. So the whole field of oncology began to see this reversal of the Krebs cycle as a kind of metabolic rewiring that helps cancer cells grow....

[C]ancers aren't caused simply by some genetically deterministic mutation that forces cells to go on growing without stopping. Metabolism is important too, for providing a permissive environment for growth. Growth comes before genes in this sense.

Or, as Slashdot reader Beeftopia puts it, "In Lane's view, metabolism came first, and genetic information emerged naturally from it rather than the other way around. Lane believes that the implications of this reversal touch almost every big mystery in biology, including the nature of cancer and aging."
Books

Are Plants 'Intelligent'? (theguardian.com) 128

Long-time Slashdot reader Dr_Ish writes: It is not too common for the world of academic philosophy to be changed by a new discovery, or innovation. Perhaps the last time this happened in a major way can be traced back to Turing's famous (1950) "Computational Machinery and Intelligence" paper "Mind," where Turing proposed that computational systems could exhibit mind-like properties. However, it appears to be in the process of happening again.

In a series of recent papers and a book that was published last week, philosopher Prof. Paco Calvo from the University of Murcia, has made a compelling case that plants exhibit cognitive properties, such as memory, planning, intelligence and perhaps even numerical abilities... His book, Calvo, P. with Lawrence, N. "Planta Sapiens: The New Science of Plant Intelligence was published in the UK last week. It will appear in North America in March next year.

From the Guardian's review of the book: Calvo writes that intelligence is "not quite as special as we like to think". He argues that it's time to accept that other organisms, even drastically different ones, may be capable of it....

In the course of his book, Calvo describes many experiments that reveal plants' remarkable range, including the way they communicate with others nearby using "chemical talk", a language encoded in about 1,700 volatile organic compounds.... Other studies show that some plants retain a memory of where the sun will rise, in order to turn their leaves towards the first rays. They store this knowledge — an internal model of what the sun is going to do — for several days, even when kept in total darkness. The conclusion must be that they constantly collect information, processing and retaining it in order to "make predictions, learn, and even plan ahead".

Television

The Ashes of Four 'Star Trek' Actors Will Be Carried Into Deep Space (cnn.com) 65

United Launch Alliance has been developing a heavy-lift space vehicle since 2014 (with investment from the U.S. military) called the Vulcan Centaur.

So CNN reports that the ashes of the late Star Trek actress Nichelle Nichols "will head to deep space on a Vulcan rocket." Nichols' cremated remains will be aboard the first Celestis Voyager Memorial Spaceflight, which will launch from Cape Canaveral, Florida. Celestis, Inc., is a private company that conducts memorial spaceflights. Among the remains also aboard the flight will be the ashes of "Star Trek" creator Gene Roddenberry; his wife, Majel Barrett-Roddenberry, who played various roles in the show and films; and James Doohan, who played Montgomery "Scotty" Scott in the films and TV series....

The spaceflight will travel beyond NASA's James Webb Space Telescope and into interplanetary deep space. In addition to cremated remains, capsules onboard will also carry complete human genome DNA samples from willing participants.

People can participate in the flight — by having DNA or loved ones' remains in a spaceflight container — for a price starting at $12,500, and reservations close August 31. (Celestis offers other voyages that don't travel as far, but can cost less than $5,000.) Ahead of the flight's liftoff, Celestis will host a three-day event with mission briefings, an astronaut-hosted dinner, launch site tours, an on-site memorial service and launch viewing. All events will be shown via webcast, according to Celestis.

An announcement on the flight's site invites fans of Nichelle Nichols to "share your own story about how she inspired you and it will be sent into deep space aboard the first Celestis Voyager Memorial Spaceflight — the Enterprise Flight, launching later in 2022."
Space

Neal Stephenson Thinks Rockets are an Overhyped Technology (politico.com) 220

Every Friday Politico interviews someone about "The Future in Five Questions". This week they interviewed Neal Stephenson (who they describe as "the sci-fi author who coined the term 'metaverse' and now a Web3 entrepreneur in his own right.")

Stephenson began by sharing his thoughts on a big idea that's underrated. Neal Stephenson: Desalination. It's an incredibly obvious, kind of simple process. Nothing is more basic than having water to drink, so it's kind of hiding in plain sight, but coupled with cheap energy from photovoltaics it's going to make big changes in the world. When you look at how much water, or a lack thereof, has shaped where people live and how people make food, the notion that we might be able to engineer ways to get fresh water in a new way could be revolutionary.

What's a technology you think is overhyped?

Stephenson: I'm going to go with an oldie: rockets. It's just a historical accident that chemical rockets became our only way of putting stuff into space, and if we had started at a different time we would have ended up doing something that works better.

One alternative would be beaming energy from the ground to vehicles, using lasers or microwaves. That seems like a doable project right now. There's nuclear propulsion, which I think is probably never going to happen at scale, because it's politically impossible, but even something as simple as constructing a very tall building or a tall tower and using that as a launch platform, or as a way to accelerate things up upward, could really change the economics of spaceflight.

Stephenson also says the book that most shaped his conception of the future was Robert Heinlein's 1958 novel Have Spacesuit, Will Travel. And the biggest surprise of 2022 was Ukraine's strong response after Russia's invasion. "Most people who are paying attention have understood that drones and other new technologies are going to change the way wars get fought, but we're seeing it unfold and mutate in real time in Ukraine.

"These guys are taking old Cold War grenades and disassembling them, and putting on homemade fuses and attaching 3D printed fins and dropping them out of consumer-grade drones, to a significant effect on the battlefield...."

In 2004 Neal Stephenson answered questions from Slashdot's readers.
Medicine

This Is Not the Monkeypox That Doctors Thought They Knew (yahoo.com) 97

"At the onset of the outbreak, scientists thought they knew when and how the monkeypox virus was spread, what the disease looked like and who was most vulnerable," remembers the New York Times.

"The 47,000 cases identified worldwide have upended many of those expectations." Some had headaches or depression, confusion and seizures. Others had severe eye infections or inflammation of the heart muscle. At least three of the six deaths reported so far were linked to encephalitis, an inflammation of the brain. "We really are seeing a very, very wide range of presentation," said Dr. Boghuma Titanji, an infectious disease physician at a clinic in Atlanta that serves people living with H.I.V. Scientists now know that the monkeypox virus lurks in saliva, semen and other bodily fluids, sometimes for weeks after recovery. The virus has always been known to spread through close contact, but many researchers suspect the infection may also be transmitted through sex itself....

"It's no longer correct to say it can't be transmitted asymptomatically," said Dr. Chloe Orkin, an infectious disease physician at Queen Mary University of London. "I think that it means that our working model of how it's spread is incorrect."

Early in the outbreak, [America's Centers for Disease Control] said that "people who do not have monkeypox symptoms cannot spread the virus to others." The agency changed that phrasing on July 29 to say that "scientists are still researching" the possibility of asymptomatic transmission. In a statement to The New York Times, an agency spokeswoman acknowledged recent evidence that asymptomatic cases were possible but said that it was still uncertain whether people without symptoms could spread the virus and that more research was needed.

Science

Psilocybin Therapy Sharply Reduces Excessive Drinking, Small Study Shows (nytimes.com) 89

A small study on the therapeutic effects of using psychedelics to treat alcohol use disorder found that just two doses of psilocybin magic mushrooms paired with psychotherapy led to an 83 percent decline in heavy drinking among the participants. Those given a placebo reduced their alcohol intake by 51 percent. From a report: By the end of the eight-month trial, nearly half of those who received psilocybin had stopped drinking entirely compared with about a quarter of those given the placebo, according to the researchers. The study, published Wednesday in JAMA Psychiatry, is the latest in a cascade of new research exploring the benefits of mind-altering compounds to treat a range of mental health problems, from depression, anxiety and post-traumatic stress disorder to the existential dread experienced by the terminally ill.

Although most psychedelics remain illegal under federal law, the Food and Drug Administration is weighing potential therapeutic uses for compounds like psilocybin, LSD and MDMA, the drug better known as Ecstasy. Dr. Michael Bogenschutz, director at NYU Langone Center for Psychedelic Medicine and the study's lead investigator, said the findings offered hope for the nearly 15 million Americans who struggle with excessive drinking -- roughly 5 percent of all adults. Excessive alcohol use kills an estimated 140,000 people each year.

China

China Deploys Rain-Seeding Drones To End Drought in Sichuan (bloomberg.com) 24

China is using two massive drones to seed rainclouds in Sichuan province to try to end a devastating drought that has choked power output and disrupted supply chains of global giants like Apple and Tesla. From a report: The China Meteorological Administration launched drones in northern and southeastern Sichuan on Thursday morning, and the aircraft will eventually cover an area of 6,000 square kilometers in operations lasting through Monday, state-owned CCTV reported. Seeding works by dropping an ice-forming agent like silver iodide into a cloud that already contains ample moisture. Rain droplets gather around the agent, gaining weight until they begin to fall. China has a long history of using the technology to water crop fields, cool blistering cities and make sure skies are clear for events like the Olympics.
United States

White House Pushes Journals To Drop Paywalls on Publicly Funded Research (nytimes.com) 39

Academic journals will have to provide immediate access to papers that are publicly funded, providing a big win for advocates of open research and ending a policy that had allowed publishers to keep publications behind a paywall for a year, according to a White House directive. The New York Times: In laying out the new policy, which is set to be fully in place by the start of 2026, the Office of Science and Technology Policy said that the guidance had the potential to save lives and benefit the public on several key priorities -- from cancer breakthroughs to clean-energy technology. "The American people fund tens of billions of dollars of cutting-edge research annually," Dr. Alondra Nelson, the head of the office, said in a statement. "There should be no delay or barrier between the American public and the returns on their investments in research."

Advocates for open-research access, like Greg Tananbaum, the director of the Open Research Funders Group, called the guidance "transformational" for researchers and the broader public alike. He said it built off a 2013 memorandum that was also important in expanding the public's access to research but fell short in some areas. The 2013 guidance applied to federal agencies with research and development expenditures of $100 million or more, about 20 of the largest agencies like the National Science Foundation and the National Institutes of Health. The guidance announced on Thursday covers nearly all federal bodies, a major expansion that includes about 400 or more entities, several experts said. The directive also requires that publications be made available in machine-readable formats to ensure use and reuse, a component that open-access advocates hailed as a game-changer for accessibility.

Medicine

Moderna Sues Pfizer Over Covid-19 Vaccine Patents (npr.org) 68

The vaccine manufacturer Moderna sued Pfizer and BioNTech on Friday, claiming that its rivals' Covid-19 shot violates its patents protecting its groundbreaking technology. NPR reports: The lawsuit alleges the two companies used certain key features of technology Moderna developed to make their COVID-19 vaccine. It argues that Pfizer and BioNtech's vaccine infringes patents Moderna filed between 2010 and 2016 for its messenger RNA or mRNA technology.

All three companies' COVID-19 vaccines used mRNA technology which is a new way to make vaccines. In the past, vaccines were generally made using parts of a virus, or inactivated virus, to stimulate an immune response. With mRNA technology, the vaccine uses messenger RNA created in a lab to send genetic instructions that teach our cells to make a protein or part of a protein that triggers an immune response. In October 2020, Moderna pledged not to enforce its COVID-19 related patents while the pandemic was ongoing, according to a statement from the company. In March this year, it said it will stick to its commitment not to enforce its COVID-19 related patents in low and middle-income countries, but expects rival companies like Pfizer to respect its intellectual property.

Earth

Ethanol Helps Plants Survive Drought (cnn.com) 26

Bruce66423 shares a report from The Telegraph: Academics from Japan have found that ethanol helps make plants more drought-resistant (Warning: source paywalled; alternative source) and better able to survive an extended bout of dry weather. Experiments found that getting plants drunk helps crops flourish while sober plants become shrunken and disheveled. Plants lose water through their leaves when pores called stomata open to allow it to escape, but ethanol helps keep these closed, the scientists found, thus improving water retention. Genetic analysis of the plant also showed that plants switch on drought-fighting genes when ethanol is picked up by the roots. This not only stopped the loss of water through the vent-like stomata but also saw the plant activate a process where it actually uses the alcohol for fuel.

Photosynthesis, the vital process that plants use to make energy from sunlight, needs water, but in the study, published in the journal Plant and Cell Physiology, the team found the plant can do this with ethanol instead in times of drought to further conserve dwindling supplies while also still making energy. This metabolizing of alcohol also means that shops would not be stocked with alcohol-infused foods if an alcohol-aided plant was harvested as it would have long ago been turned into energy by the plant.
"There are some interesting questions to ask about WHY this pathway exists in plants," adds Slashdot reader Bruce66423. "The article doesn't talk about the concentration needed."
Space

Carbon Dioxide Detected Around Alien World For First Time (science.org) 24

sciencehabit quotes a report from Science Magazine: Astronomers have found carbon dioxide (CO2) in the atmosphere of a Saturn-size planet 700 light-years away -- the first unambiguous detection of the gas in a planet beyond the Solar System. The discovery, made by the James Webb Space Telescope, provides clues to how the planet formed. The result also shows just how quickly Webb may identify a spate of other gases, such as methane and ammonia, which could hint at a planet's potential habitability for life. [...] For its first exoplanet observations, astronomers targeted the hot gas giant WASP-39b, which orbits its star every 4 days in an orbit much tighter than Mercury's. The first data were taken on 10 July and the team started work on them a few days later. Even in raw data based on a single transit across the star, the spectral dip of CO2 "sticks out like a sore thumb," says Webb team member Jacob Bean of the University of Chicago. There have been some tentative detections of the gas before, he says, but none of them held up under scrutiny. Webb's spectrum was "the right size, the right shape, and in the right position," Bean says. "CO2 just popped out."

Finding CO2 is valuable because it is a clue to a planet's "metallicity" -- the proportion of elements heavier than helium in its makeup. Hydrogen and helium produced in the big bang are the starting materials for all the visible matter in the universe, but anything heavier was forged later in stars. Researchers believe a good supply of heavy elements is crucial for creating giant planets. When planets form out of a disk of material around a new star, heavier elements form solid grains and pebbles that glom together into a solid core that eventually is massive enough to pull in gases with its own gravity and grow into a gas giant. With Webb, finding "important chemicals will be the norm rather than the exception," says one expert. He predicts that when Webb starts to study cooler planets closer in size to Earth, there will be some real surprises -- perhaps some gases that could indicate whether the planets are amenable to life. "It's anyone's guess," he says. "A whole zoo of chemicals is possible."
The findings first appeared on the preprint server arXiv yesterday and they will appear in Nature in the near future.
Science

Scientists Grew a Synthetic Mouse Embryo With a Brain and a Beating Heart (sciencealert.com) 31

An anonymous reader quotes a report from ScienceAlert: In a monumental leap in stem cell research, an experiment led by researchers from the University of Cambridge in the UK has developed a living model of a mouse embryo complete with fluttering heart tissues and the beginnings of a brain. The research advances the recent success of a team comprised of some of the same scientists who pushed the limits on mimicking the embryonic development of mice using stem cells that had never seen the inside of a mouse womb. In the past, researchers in embryology have focused largely on plucking choice stem cells from parts of an embryo that would grow into an animal and encouraging them to proliferate in glassware full of specially selected nutrients. Over the years, this method has resulted in clumps of cells containing the basic starting structures of a gut and a fold of tissues called the neural tube. What the so-called 'gastruloid' model contains in form, however, it lacks in function. Many features expected to develop alongside these tissues aren't present, making it harder to draw parallels between the model and an authentic growing embryo. There are ways to encourage brain-like structures to appear, as well as functioning heart tissue and a more complex gut tube. Yet workarounds based on comparatively simple hormonal soups can only go so far.

Mixing stem cells representative from these three major tissue groups and improving on previous methods for their development in vitro (that means in a dish) into an embryoid, the team found their model could progress under its own steam to develop a nervous system equivalent to a natural mouse embryo at 8.5 days post-conception. The step is a small one, equivalent to just a single day of development for an unborn mouse. But a lot can happen in that 24 hours of gestation. The synthetic embryoid also contained foundational heart tissue that twitched out a beat and the beginnings of a gut, as well as the start of structures that in an actual embryo could build parts of the skeleton, muscles, and other tissues beneath the skin. On its own, the model wouldn't continue to develop into anything like a thriving baby mouse. Science is far from able to produce anything so advanced as a functional organ from stem cells alone, let alone an entire animal. While the resemblance is quite significant in research, it is -- so to speak -- only skin deep, lacking the signals that would see it transform into the fully-formed organism it models. Having a collection of tissues that authentically reflects development outside of a body provides researchers with the opportunity to not only observe, but ethically test genetic changes that could help improve our understanding of how our bodies grow.
The findings appear in a study published in the journal Nature.
Power

New Aluminum-Sulfur Battery Tech Offers Full Charging In Under a Minute (mit.edu) 116

According to a new paper published in the journal Nature, researchers at MIT describe new aluminum-sulfur batteries that are made entirely from abundant and inexpensive materials and can be charged in less than a minute. "The new battery architecture, which uses aluminum and sulfur as its two electrode materials, with a molten salt electrolyte in between, is described today in the journal Nature, in a paper by MIT Professor Donald Sadoway, along with 15 others at MIT and in China, Canada, Kentucky, and Tennessee," reports MIT News. The caveat with this new kind of battery is that it requires a variety of molten salts that need to be "close to the boiling point of water." From the report: In their experiments, the team showed that the battery cells could endure hundreds of cycles at exceptionally high charging rates, with a projected cost per cell of about one-sixth that of comparable lithium-ion cells. They showed that the charging rate was highly dependent on the working temperature, with 110 degrees Celsius (230 degrees Fahrenheit) showing 25 times faster rates than 25 C (77 F). Surprisingly, the molten salt the team chose as an electrolyte simply because of its low melting point turned out to have a fortuitous advantage. One of the biggest problems in battery reliability is the formation of dendrites, which are narrow spikes of metal that build up on one electrode and eventually grow across to contact the other electrode, causing a short-circuit and hampering efficiency. But this particular salt, it happens, is very good at preventing that malfunction. The chloro-aluminate salt they chose "essentially retired these runaway dendrites, while also allowing for very rapid charging," Sadoway says. "We did experiments at very high charging rates, charging in less than a minute, and we never lost cells due to dendrite shorting."

What's more, the battery requires no external heat source to maintain its operating temperature. The heat is naturally produced electrochemically by the charging and discharging of the battery. "As you charge, you generate heat, and that keeps the salt from freezing. And then, when you discharge, it also generates heat," Sadoway says. In a typical installation used for load-leveling at a solar generation facility, for example, "you'd store electricity when the sun is shining, and then you'd draw electricity after dark, and you'd do this every day. And that charge-idle-discharge-idle is enough to generate enough heat to keep the thing at temperature." This new battery formulation, he says, would be ideal for installations of about the size needed to power a single home or small to medium business, producing on the order of a few tens of kilowatt-hours of storage capacity.

For larger installations, up to utility scale of tens to hundreds of megawatt hours, other technologies might be more effective, including the liquid metal batteries Sadoway and his students developed several years ago and which formed the basis for a spinoff company called Ambri, which hopes to deliver its first products within the next year. For that invention, Sadoway was recently awarded this year's European Inventor Award. The smaller scale of the aluminum-sulfur batteries would also make them practical for uses such as electric vehicle charging stations, Sadoway says. He points out that when electric vehicles become common enough on the roads that several cars want to charge up at once, as happens today with gasoline fuel pumps, "if you try to do that with batteries and you want rapid charging, the amperages are just so high that we don't have that amount of amperage in the line that feeds the facility." So having a battery system such as this to store power and then release it quickly when needed could eliminate the need for installing expensive new power lines to serve these chargers.
"The first order of business for the company is to demonstrate that it works at scale," Sadoway says, and then subject it to a series of stress tests, including running through hundreds of charging cycles.

If you're looking for a detailed breakdown of how this new battery works, we recommend you check out Ars Technica's article here.
Science

Insects Could Give Meaty Taste To Food and Help Environment, Scientists Say 211

Insects can be turned into meat-like flavors, helping provide a more environmentally friendly alternative to traditional meat options, scientists have discovered. From a report: Mealworms, the larval form of the yellow mealworm beetle, have been cooked with sugar by researchers who found that the result is a meat-like flavoring that could one day be used on convenience food as a source of protein. While mealworms have until now mostly been used as snacks for pets or as bait while fishing, they have potential as a food source for humans to help get the recognizable flavors of meat without the harmful impacts upon the climate, as well as direct air and water pollution, of raising beef, pork and other animal-based foods. "Insects are a nutritious and healthy food source with high amounts of fatty acids, vitamins, minerals, fiber and high-quality protein, which is like that of meat," says In Hee Cho, a researcher at Wonkwang University in South Korea who led the study.

"Many consumers seriously like and need animal protein in our diet. However, traditional livestock farming produces more greenhouse gas emissions than cars do. On the other hand, insect farming requires just a fraction of the land, water and feed in comparison to traditional livestock farming." Cho said that edible insects, such as mealworms and crickets, were "superfoods" that have long been enjoyed by communities in Asia, Africa and South America. However, people in Europe and North America are generally more squeamish about eating insects, despite recent forays by several restaurants and supermarkets into providing insect options for consumers.

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