Hmmmmmm shares a report from the Associated Press: Eight years ago, a team of researchers launched a project to carefully repeat early but influential lab experiments in cancer research. They recreated 50 experiments, the type of preliminary research with mice and test tubes that sets the stage for new cancer drugs. The results reported Tuesday: About half the scientific claims didn't hold up. [...] For the project, the researchers tried to repeat experiments from cancer biology papers published from 2010 to 2012 in major journals such as Cell, Science and Nature. Overall, 54% of the original findings failed to measure up to statistical criteria set ahead of time by the Reproducibility Project, according to the team's [two studies] published online Tuesday by eLife. The nonprofit eLife receives funding from the Howard Hughes Medical Institute, which also supports The Associated Press Health and Science Department.

Among the studies that did not hold up was one that found a certain gut bacteria was tied to colon cancer in humans. Another was for a type of drug that shrunk breast tumors in mice. A third was a mouse study of a potential prostate cancer drug. The researchers tried to minimize differences in how the cancer experiments were conducted. Often, they couldn't get help from the scientists who did the original work when they had questions about which strain of mice to use or where to find specially engineered tumor cells. "I wasn't surprised, but it is concerning that about a third of scientists were not helpful, and, in some cases, were beyond not helpful," said Michael Lauer, deputy director of extramural research at the National Institutes of Health. NIH will try to improve data sharing among scientists by requiring it of grant-funded institutions in 2023, Lauer said.

An anonymous reader quotes a report from NPR: It's Dr. Francis Collins' last few weeks as director of the National Institutes of Health after 12 years, serving under three presidents. Collins made his name doing the kind of biomedical research NIH is famous for, especially running The Human Genome Project, which fully sequenced the human genetic code. The focus on biomedicine and cures has helped him grow the agency's budget to over $40 billion a year and win allies in both political parties.

Still, in a broad sense, Americans' health hasn't improved much in those 12 years, especially compared with people in peer countries, and some have argued the agency hasn't done enough to try to turn these trends around. One recently retired NIH division director has quipped that one way to increase funding for this line of research would be if "out of every $100, $1 would be put into the 'Hey, how come nobody's healthy?' fund."

In a wide-ranging conversation, Collins answers NPR's questions as to why -- for all the taxpayer dollars going to NIH research -- there haven't been more gains when it comes to Americans' overall health. He also talks about how tribalism in American culture has fueled vaccine hesitancy, and he advises his successor on how to persevere on research of politically charged topics -- like guns and obesity and maternal health -- even if powerful lobbies might want that research not to get done. In regard to Americans not getting healthier over the last 12 years, NPR asked Collins why there haven't been more gains and what role NIH should play in understanding these trends and trying to turn them around. Here's what he said: Well, sure, it does bother me. In many ways, the 28 years I have been at NIH have just been an amazing ride of discoveries upon discoveries. But you're right, we haven't seen that translate necessarily into advances. Let's be clear, there are some things that have happened that are pretty exciting. Cancer deaths are dropping every year by 1 or 2%. When you add that up over 20 years, cancer deaths are down by almost 25% from where they were at the turn of the century. And that's a consequence of all the hard work that's gone into developing therapeutics based on genomics, as well as immunotherapy that's made a big dent in an otherwise terrible disease.

But we've lost ground in other areas, and a lot of them are a function of the fact that we don't have a very healthy lifestyle in our nation. Particularly with obesity and diabetes, those risk factors have been getting worse instead of better. We haven't, apparently, come up with strategies to turn that around. On top of that, the other main reason for seeing a drop in life expectancy -- other than obesity and COVID -- is the opioid crisis. We at NIH are working as fast and as hard as we can to address that by trying to both identify better ways to prevent and treat drug addiction, but also to come up with treatments for chronic pain that are not addictive, because those 25 million people who suffer from chronic pain every day deserve something better than a drug that is going to be harmful.

In all of these instances, as a research enterprise -- because that's our mandate -- it feels like we're making great progress. But the implementation of those findings runs up against a whole lot of obstacles, in terms of the way in which our society operates, in terms of the fact that our health care system is clearly full of disparities, full of racial inequities. We're not -- at NIH -- able to reach out and fix that, but we can sure shine a bright light on it and we can try to come up with pilot interventions to see what would help.

fahrbot-bot shares a report from ScienceAlert: Usage of the medication sildenafil -- better known to most as the brand-name drug Viagra -- is associated with dramatically reduced incidence of Alzheimer's disease, new research suggests. According to a study led by researchers at the Cleveland Clinic, taking sildenafil is tied to a nearly 70 percent lower risk of developing Alzheimer's compared to non-users. That's based on an analysis of health insurance claim data from over 7.2 million people, in which records showed that claimants who took the medication were much less likely to develop Alzheimer's over the next six years of follow up, compared to matched control patients who didn't use sildenafil.

It's important to note that observed associations like this -- even on a huge scale -- are not the same as proof of a causative effect. For example, it's possible that the people in the cohort who took sildenafil might have something else to thank for their improved chances of not developing Alzheimer's. Nonetheless, the researchers say the correlation shown here -- in addition to other indicators in the study -- is enough to identify sildenafil as a promising candidate drug for Alzheimer's disease, the viability of which can be explored in future randomized clinical trials designed to test whether causality does indeed exist.

Reeses writes: The Debrief just reported that DARPA just "accidentally" created the world's first warp bubble. From the article:

Warp drive pioneer and former NASA warp drive specialist Dr. Harold G "Sonny" White has reported the successful manifestation of an actual, real-world "Warp Bubble." And, according to White, this first of its kind breakthrough by his Limitless Space Institute (LSI) team sets a new starting point for those trying to manufacture a full-sized, warp-capable spacecraft.

There's also a video of the announcement, The Very First Warp-Bubble Created by DARPA Funded Team.

European space company ArianeGroup will develop a reusable mini-launcher to compete with the likes of Elon Musk's SpaceX, French Finance Minister Bruno Le Maire said on Monday. Reuters reports: The launcher "must be able to be operational in 2026," Le Maire said during a trip to the ArianeGroup site at Vernon in Normandy, where the engines of Ariane rockets are tested. "For the first time Europe...will have access to a reusable launcher. In other words, we will have our SpaceX, we will have our Falcon 9. We will make up for a bad strategic choice made 10 years ago," Le Maire said.

Astronomers say they've located six galaxies that appear to have either very little or absolutely no dark matter. The team will present its findings in Monthly Notices of the Royal Astronomical Society. CNET reports: Mentioning that they'd previously been told "measure again, you'll see there will be dark matter around your galaxy," the researchers zeroed in on one seemingly dark-matter-free region dubbed AGC 114905 to strengthen their evidence. Lurking 250 million light-years away from Earth, it's about the size of the Milky Way, with a thousand times fewer stars. So it's rather dim. The researchers used a standard technique to detect the presence of dark matter in AGC 114905 that involves graphing the position and rotation speed of the galaxy's gas. After 40 hours of scrutiny with the high-powered Very Large Array Radio Telescope in New Mexico, they found the movements of the gas were perfectly explainable by normal matter alone.

"The problem remains that the theory predicts that there must be dark matter in AGC 114905," Pavel Mancera Piñabut of the Kapteyn Astronomical Institute at the University of Groningenour and an author of the study, said in a statement, referring to classic dark matter hypotheses. "Observations say there isn't -- in fact, the difference between theory and observation is only getting bigger." One caveat, the team says, is that perhaps the angle at which they viewed AGC 114905 affected their observational results. "But that angle has to deviate very much from our estimate before there is room for dark matter again," Tom Oosterloo of Astron at the Netherlands Institute for Radio Astronomy and co-author of the study, said in a statement.

And if they're correct? The team offers up a few reasons for why AGC 114905 may not have any dark matter. For instance, what if super large galaxies nearby somehow stripped it of the force? As a rebuttal, though, Mancera Pinabut says there don't seem to be any such galaxies in the vicinity. Further, he says, "in the most reputed galaxy formation framework, the so-called cold dark matter model, we would have to introduce extreme parameter values that are far beyond the usual range. Also with modified Newtonian dynamics, an alternative theory to cold dark matter, we cannot reproduce the motions of the gas within the galaxy."

Chinese weather authorities successfully controlled the weather ahead of a major political celebration earlier this year, according to a Beijing university study. The Guardian reports: On 1 July the Chinese Communist party marked its centenary with major celebrations including tens of thousands of people at a ceremony in Tiananmen Square, and a research paper from Tsinghua University has said an extensive cloud-seeding operation in the hours prior ensured clear skies and low air pollution. [...] On Monday the South China Morning Post reported a recent research paper which found definitive signs that a cloud-seeding operation on the eve of the centenary had produced a marked drop in air pollution.

The centenary celebration faced what the paper reportedly termed unprecedented challenges, including an unexpected increase in air pollutants and an overcast sky during one of the wettest summers on record. Factories and other polluting activities had been halted in the days ahead of the event but low airflow meant the pollution hadn't dissipated, it said. The paper, published in the peer-reviewed Environmental Science journal and led by environmental science professor, Wang Can, said a two-hour cloud-seeding operation was launched on the eve of the ceremony, and residents in nearby mountain regions reported seeing rockets shot into the sky on 30 June. The paper said the rockets were carrying silver iodine into the sky to stimulate rainfall.

The researchers said the resulting artificial rain reduced the level of PM2.5 air pollutants by more than two-thirds, and shifted the air quality index reading, based on World Health Organization standards, from "moderate" to "good." The team said the artificial rain "was the only disruptive event in this period," so it was unlikely the drop in pollution had a natural cause.

The artificial intelligence (AI) program DeepMind has gotten closer to proving a math conjecture that's bedeviled mathematicians for decades and revealed another new conjecture that may unravel how mathematicians understand knots. Live Science reports: The two pure math conjectures are the first-ever important advances in pure mathematics (or math not directly linked to any non-math application) generated by artificial intelligence, the researchers reported Dec. 1 in the journal Nature. [...] The first challenge was setting DeepMind onto a useful path. [...] They focused on two fields: knot theory, which is the mathematical study of knots; and representation theory, which is a field that focuses on abstract algebraic structures, such as rings and lattices, and relates those abstract structures to linear algebraic equations, or the familiar equations with Xs, Ys, pluses and minuses that might be found in a high-school math class.

In understanding knots, mathematicians rely on something called invariants, which are algebraic, geometric or numerical quantities that are the same. In this case, they looked at invariants that were the same in equivalent knots; equivalence can be defined in several ways, but knots can be considered equivalent if you can distort one into another without breaking the knot. Geometric invariants are essentially measurements of a knot's overall shape, whereas algebraic invariants describe how the knots twist in and around each other. "Up until now, there was no proven connection between those two things," [said Alex Davies, a machine-learning specialist at DeepMind and one of the authors of the new paper], referring to geometric and algebraic invariants. But mathematicians thought there might be some kind of relationship between the two, so the researchers decided to use DeepMind to find it. With the help of the AI program, they were able to identify a new geometric measurement, which they dubbed the "natural slope" of a knot. This measurement was mathematically related to a known algebraic invariant called the signature, which describes certain surfaces on knots.

In the second case, DeepMind took a conjecture generated by mathematicians in the late 1970s and helped reveal why that conjecture works. For 40 years, mathematicians have conjectured that it's possible to look at a specific kind of very complex, multidimensional graph and figure out a particular kind of equation to represent it. But they haven't quite worked out how to do it. Now, DeepMind has come closer by linking specific features of the graphs to predictions about these equations, which are called Kazhdan-Lusztig (KL) polynomials, named after the mathematicians who first proposed them. "What we were able to do is train some machine-learning models that were able to predict what the polynomial was, very accurately, from the graph," Davies said. The team also analyzed what features of the graph DeepMind was using to make those predictions, which got them closer to a general rule about how the two map to each other. This means DeepMind has made significant progress on solving this conjecture, known as the combinatorial invariance conjecture.

In an open letter to Mark Zuckerberg published Monday, a group of academics called for Meta to be more transparent about its research into how Facebook, Instagram, and WhatsApp affect the mental health of children and adolescents. The Verge reports: The letter calls for the company to allow independent reviews of its internal work, contribute data to external research projects, and set up an independent scientific oversight group. "You and your organizations have an ethical and moral obligation to align your internal research on children and adolescents with established standards for evidence in mental health science," the letter, signed by researchers from universities around the world, reads.

The open letter comes after leaks from Facebook revealed some data from the company's internal research, which found that Instagram was linked with anxiety and body image issues for some teenage girls. The research released, though, is limited and relied on subjective information collected through interviews. While this strategy can produce useful insights, it can't prove that social media caused any of the mental health outcomes. The information available so far appears to show that the studies Facebook researchers conducted don't meet the standards academic researchers use to conduct trials, the new open letter said. The information available also isn't complete, the authors noted -- Meta hasn't made its research methods or data public, so it can't be scrutinized by independent experts. The authors called for the company to allow independent review of past and future research, which would include releasing research materials and data.

The letter also asked Meta to contribute its data to ongoing independent research efforts on the mental health of adolescents. It's a longstanding frustration that big tech companies don't release data, which makes it challenging for external researchers to scrutinize and understand their products. "It will be impossible to identify and promote mental health in the 21st century if we cannot study how young people are interacting online," the authors said. [...] The open letter also called on Meta to establish an independent scientific trust to evaluate any risks to mental health from the use of platforms like Facebook and Instagram and to help implement "truly evidence-based solutions for online risks on a world-wide scale." The trust could be similar to the existing Facebook Oversight Board, which helps the company with content moderation decisions.

The Yutu-2 rover is on a roll. It's been exploring the far side of the moon since early 2019 as part of China's Chang'e-4 lunar lander mission. It now has its eyes set on a strange-looking cube-shaped object it spotted in the distance. From a report: Andrew Jones, a journalist who covers the Chinese space program for SpaceNews and Space.com, highlighted a new rover update in a series of tweets Friday. The nickname for the cube-shaped object translates to "mystery house." The rover team is planning to drive over and get a closer look at the object. As with Yutu-2's intriguing discovery of a "gel-like" substance inside a crater in 2019, don't get too excited for aliens. That substance turned out to be glassy-looking rock. And as far as I know, Stanley Kubrick never planted a monolith on the real moon, and those metal sculptures that were once all the rage on Earth haven't made the trek across space. Yutu-2's view of the cube is fuzzy and far-off, so the object's true nature should become clearer as the rover gets closer. The most likely explanation is a boulder. This part of the moon is pockmarked with impact craters, which can feature quite a bit of chunky debris.

An indestructible "black box" is set to be built upon a granite plain on the west coast of Tasmania, Australia, in early 2022. Its mission: Record "every step we take" toward climate catastrophe, providing a record for future civilizations to understand what caused our demise, according to the Australian Broadcasting Corporation. From a report: The project, led by marketing communications company Clemenger BBDO in collaboration with University of Tasmania researchers, is currently in beta and has already begun collecting information at its website. The structure is designed to be about the size of a city bus, made of 3-inch-thick steel and topped with solar panels. Its interior will be filled with "storage drives" that gather climate change-related data such as atmospheric carbon dioxide levels and average temperatures. In addition, using an algorithm, it will scour the web for tweets, posts, news and headlines.

The developers estimate that storage will run out in 30 to 50 years, according to the ABC. There are plans to increase the storage capacity and provide a more long-term solution, but it's unclear how the structure will be maintained -- how its solar panels might be replaced before the end of civilization, how well those drives hold up after decades and how impervious the vault will be to vandalism or sabotage. Its remote location, around four hours from the closest major city, is one deterrent -- but will that be enough?

Smithsonian magazine explores the many Mars simulation facilities around the world, including the Mars Desert Research Station — which is located in Utah, four hours south of Salt Lake City, "but everyone spoke and acted as though they were actually on Mars." A group of six people lived in a two-story cylindrical building. The commander, a former member of the Army National Guard, kept the participants on a strict schedule of fixing electrical systems, taking inventory, tidying up the facilities and sampling the soil. Everyone was assigned a special role: [photographer] Klos' was to prepare reports to share with the public. The health safety officer kept tabs on the crew's well-being, and the engineer monitored levels of carbon dioxide and solar power. Before stepping outside in a spacesuit, Klos and the others had to get permission from mission control back on "Earth" (actually a coordinator stationed in a nearby town). That person would send information about the winds and weather, and determine how long each person could stay outside the base. Sometimes dust storms rolled in, cutting off the solar power supply just as they would on Mars...

There are about a dozen such habitats around the globe, hosting simulations that run anywhere from two weeks to a full year. One of these is run by NASA's Human Research Program at the Johnson Space Center in Houston. But other facilities are funded by private organizations. The Mars Society, established by Brooklyn-born aerospace engineer Robert Zubrin, operates the habitat in Utah, where Klos returned for another mission in 2017, and another in the Canadian Arctic. Klos also took part in a mission at the Hawaii Space Exploration Analog and Simulation, or HI-SEAS. The facility is run by the International MoonBase Alliance, a group founded by the Dutch entrepreneur Henk Rogers.

HI-SEAS is located on Hawaii's big island at 8,200 feet above sea level, on top of the active volcano Mauna Loa. NASA's Goddard Space Flight Center is collaborating with the facility to gather information about volcanic caves and the microbes that live in those Mars-like conditions. HI-SEAS is also studying the limitations of doing that kind of work while wearing heavy spacesuits. It's hard enough for astronauts to hold a screwdriver in a gloved hand while repairing the International Space Station, but if people are going to be clambering on Martian rocks looking for microbes, they'll need the right gear.
The article notes these missions "are open to people who have no background in science, engineering or astronaut training. After all, the goal is to send ordinary folks into space, so it's worth finding out whether ordinary folks can coexist in Mars-like conditions here on Earth." (Some are even recruited off the internet.) "Sometimes people make the critique that we're role-playing too much," the photographer tells the magazine. "But the goal is to really live the way people are going to live on Mars so scientists can figure out how to make it work when we get there."

And the article also points out that "The data we're gathering now about surviving on solar power, conserving water and growing plants in arid conditions could be useful here at home as our climate changes."

Last week researchers at Northwestern University calculated that one week after a Covid-19 booster shot, median antibody levels were 23 times higher than before the shot.

This Thursday the Times of London reported that another study found similar results: Booster jabs "massively" strengthen the body's defences against Covid, according to key results that have raised hopes of strong protection from the Omicron variant. A third dose not only increased antibody levels thirtyfold, but roughly tripled levels of T-cells, a part of the immune system that experts believe could be the critical weapon against the heavily mutated Omicron strain.
Professor Saul Faust, who led the study, emphasized to the Guardian that "These are remarkably effective immunological boosters, way above what is needed to prevent hospitalisation and death."

And speaking to The Week, Faust also added that "This T-cell response gives us hope," because although Omicron was not specifically analysed during the research, their data suggested the triggered T-cells "are recognising a much broader range of antigens that might... be common to all of the variants."

And earlier this week long-time Slashdot reader destinyland shared more booster/Omicron news from The Hill: On Sunday, former FDA commissioner Scott Gottlieb, who sits on Pfizer's board of directors, said vaccine developers have "a pretty good degree of confidence" that people who have received booster doses on top of their initial COVID-19 vaccinations are protected against omicron. "If you talk to people in vaccine circles, people who are working on a vaccine, they have a pretty good degree of confidence that a boosted vaccine, so three full doses of vaccine, is going to be fairly protective against this new variant," he said.
Meanwhile, new Omicron-specific vaccines are also just months away, Business Insider reports: Pfizer said it will be able to manufacture and distribute an updated version of its COVID-19 vaccine within 100 days if the new variant Omicron is found to be resistant to its current vaccine... "Pfizer and BioNTech have taken actions months ago to be able to adapt the mRNA vaccine within six weeks and ship initial batches within 100 days in the event of an escape variant," the company said in a statement...

"We expect more data from the laboratory tests in two weeks at the latest. These data will provide more information about whether B.1.1.529 could be an escape variant that may require an adjustment of our vaccine if the variant spreads globally," a spokesperson told Reuters.

Moderna and Johnson & Johnson are also preparing to respond to the Omicron's possible threat. Moderna on Friday said it plans to test a variant-specific booster in the event that its current vaccine is found to be ineffective against the Omicron.
And The Hill also reports: Pfizer CEO Albert Bourla said Monday he has "a very high level of confidence" that his company's COVID-19 treatment pills are effective against the omicron variant... Bourla said Paxlovid was designed in anticipation of future possible mutations. "So that gives me very, very high level of confidence that the treatment will not be effected, our oral treatment will not be effected by this virus."

"The International Space Station dodged a fragment of a decades-old rocket body early Friday morning," reports Space.com, "continuing a stretch of space debris threats to the orbiting laboratory." On Friday (Dec. 3) at around 3 a.m. EST (0800 GMT), a Russian cargo ship docked to the International Space Station fired for a little under three minutes to lower the facility's orbit and ensure that it would pass safely by the debris, according to statements from NASA and its Russian counterpart, Roscosmos....

In a tweet posted on Wednesday (Dec. 1), Roscosmos flagged the risk posed by the rocket fragment, which it said was estimated to pass as close as 3.4 miles (5.4 kilometers) to the space station. Just the day before the alert was posted, on Tuesday (Nov. 30), NASA had been forced to delay a spacewalk scheduled for later in the day due to concerns about debris. The agency has not specified what that debris represents, but NASA astronaut Thomas Marshburn and Kayla Barron were able to conduct their excursion on Thursday (Dec. 2).
NASA identified Friday's debris was part of a 1994 U.S. Pegasus rocket, which later broke up in space 1996.

An anonymous reader quotes a report from Reuters: Israel said on Thursday it was halting the use of mobile phone tracing to curb the spread of the new coronavirus variant Omicron, a practice that had been challenged by privacy watchdogs. Prime Minister Naftali Bennett's government authorized the surveillance technology, which matches virus carriers' locations against other mobile phones nearby to determine their contacts, to be used for Omicron cases on Nov. 27. That authorization will not be renewed after it lapses at midnight between Thursday and Friday, Bennett's office said in a statement, citing "up-to-date situational assessments."

The technology, originally developed by Israel's Shin Bet security agency for counter-terrorism and counter-espionage, had "contributed over the last week to the effort to break the chain of infection", the statement said. Israel has confirmed at three cases of the new variant and at least 30 others are suspected of having contracted it, the Health Ministry said. Earlier on Thursday, Israel's Supreme Court rejected a petition by four rights groups seeking to repeal the measure. "Considering the uncertainty around the Omicron variant and its effects..., it has not been proven that the Shin Bet authorization poses a disproportionate infringement on the right to privacy which would justify its striking down," the ruling said.

Criminals have been selling fake vaccine certificates online and may be able to fool an EU system designed to verify the certificates' validity, researchers warn. BankInfoSecurity reports: [A] report released last week, "COVID-19 Vaccination Certificates in the Dark Web," which has not yet been peer-reviewed, notes that some darknet markets continue to sell supposed vaccine certificates for use in multiple countries. Four researchers - Dimitrios Georgoulias, Jens Myrup Pedersen, Morten Falch, Emmanouil Vasilomanolakis - who are all part of the Cyber Security Group at Aalborg University in Copenhagen, Denmark, reviewed vaccination certificate offerings from 17 marketplaces and 10 vendor shops. The researchers found that at least one vendor appears to be selling digital certificates, registered in Italy, that are being read as valid by mobile COVID-19 certificate-checking apps developed by both France and Denmark.

The Aalborg University researchers, however, note that many darknet markets forbid any listing containing any items related to COVID-19. But others, they say, do allow both physical and digital vaccine certificates to be offered for sale, and in some cases also "yellow vaccination cards" or other vaccination record cards that can be used as proof of vaccination, albeit only inside the country in which they were supposedly issued. "The listings are heavily focused on European countries and the United States, but there are also listings from other continents and countries, such as Brazil, Canada, Mexico and Australia," as well as Russia, the researchers write. "The pricing differs greatly between the different listings, with the cheapest certificate starting at $39 and the highest price reaching almost $2,800, which included both a physical and a digital certificate, registered in the United Kingdom," they write. Most markets accept bitcoin and monero cryptocurrencies as payment, they add, while a smaller number also take such digital coins as ethereum, cardano, litecoin and zcash. [...] The Aalborg University researchers note that buying a fake digital certificate gives the seller ample opportunity to scam a buyer.

If these fake COVID-19 certificates can indeed pass for valid ones, then one unanswered question remains: How? Many of the sites claim to have access to the systems used to issue certificates, either by hacking into them remotely, or having insiders who work at a healthcare or other health organization, the researchers say. "In the specific case of a listing on the Russian marketplace Hydra, the description even mentioned the exact location and hospital that the system was accessed from," they say. Another possibility, however, is that criminals have somehow stolen one or more private keys for the European system, which were issued to participating health organizations. If so, it would be difficult to revoke these keys, the researchers say, since doing so would invalidate what might be a large quantity of legitimate certificates too.

Australians have been named the heaviest drinkers in the world after spending more time drunk in 2020 than any other nation. The Guardian reports: An international survey (PDF) has found Australians drank to the point of drunkenness an average of 27 times a year, almost double the global average of 15. Almost a quarter of Australians reported feeling regret for becoming intoxicated. The Global Drug Survey asked more than 32,000 people from 22 countries what their drug and alcohol consumption was last year. On average, Australians drank alcohol in line with the global average of two nights a week, and became heavily drunk about once every two weeks. The French topped that metric, drinking around three times a week. Australian participants also tripled the global average on seeking emergency care for their drinking (3.9% compared with the global average of 1.2%). "Global Drug Survey researcher Dr Monica Barratt said Australia's high rate of drunkenness might be related to most of the country avoiding Covid lockdowns in 2020," the report adds. "Bar Victoria, most states and territories only went through short and sharp lockdowns, with relatively few cases or deaths, allowing hospitality venues to remain open and events to continue."

On the opposite end of the spectrum were New Zealanders, who became intoxicated "fewer times than almost any other country in the survey, getting drunk about 10 times a year," reports the Guardian. "Danes and Finns spent the most time drinking to excess after Australians, tied at 23.8 times a year. Americans came in third place, becoming intoxicated an average of 23 times in 2020, followed by the British (22.5 times)."

To better understand the coronavirus's journey from one person to another, a team of 50 scientists has for the first time created an atomic simulation of the coronavirus nestled in a tiny airborne drop of water. From a report: To create the model, the researchers needed one of the world's biggest supercomputers to assemble 1.3 billion atoms and track all their movements down to less than a millionth of a second. This computational tour de force is offering an unprecedented glimpse at how the virus survives in the open air as it spreads to a new host. "Putting a virus in a drop of water has never been done before," said Rommie Amaro, a biologist at the University of California San Diego who led the effort, which was unveiled at the International Conference for High Performance Computing, Networking, Storage and Analysis last month. "People have literally never seen what this looks like."

How the coronavirus spreads through the air became the subject of fierce debate early in the pandemic. Many scientists championed the traditional view that most of the virus's transmission was made possible by larger drops, often produced in coughs and sneezes. Those droplets can travel only a few feet before falling to the floor. But epidemiological studies showed that people with Covid-19 could infect others at a much greater distance. Even just talking without masks in a poorly ventilated indoor space like a bar, church or classroom was enough to spread the virus. Those findings pointed to much smaller drops, called aerosols, as important vehicles of infection. Scientists define droplets as having a diameter greater than 100 micrometers, or about 4 thousandths of an inch. Aerosols are smaller -- in some cases so small that only a single virus can fit inside them. And thanks to their minuscule size, aerosols can drift in the air for hours.

Scientists have raised concerns about a proposed overhaul of newborn screening that could lead to the UK becoming the first country to offer whole-genome sequencing for every baby. From a report: Speaking before the publication of plans for an NHS pilot study in which up to 200,000 babies' genomes will be sequenced and analysed, scientists suggested the initiative appeared designed to create a valuable health dataset rather than an effective method of improving the diagnosis of rare diseases. Anneke Lucassen, director of the Centre for Personalised Medicine at the University of Oxford, said that if the primary objective were improving newborn screening, there were alternative, more targeted tests that would be cheaper and potentially more reliable.

"If it was really all about [diagnosing more conditions], you could do that through other means," she said. "It's about helping to build the genomics industry in the UK and it's about creating a research resource so we can study people as they grow older." Lucassen said she was not opposed to the pilot, or even necessarily to these objectives, but wanted more transparency, "because otherwise it's sold as something that is not the full picture. The public needs to know that," she added. Sequencing the genomes of all newborns would represent a hugely ambitious upgrade to the routine "heel prick" test that all babies receive at about five days to detect nine serious health conditions including cystic fibrosis, sickle cell disease and various metabolic diseases.

schwit1 shares a report from ScienceAlert: The comet Bernardinelli-Bernstein (BB) -- the largest our telescopes have ever spotted -- is on a journey from the outer reaches of our Solar System that will see it flying relatively close to Saturn's orbit. Now, a new analysis of the data we've collected on BB has revealed something rather surprising. Digging into readings logged by the Transient Exoplanet Survey Satellite (TESS) between 2018 and 2020, researchers have discovered that BB became active much earlier, and much farther out from the Sun, than was previously thought.

A comet becomes active when light from the Sun heats its icy surface, turning ice to vapor and releasing trapped dust and grit. The resulting haze, called a coma, can be useful for astronomers in working out exactly what a particular comet is made out of. In the case of BB, it's still too far out for water to sublimate. Based on studies of comets at similar distances, it's likely that the emerging fog is driven instead by a slow release of carbon monoxide. Only one active comet has previously been directly observed at a greater distance from the Sun, and it was much smaller than BB. "These observations are pushing the distances for active comets dramatically farther than we have previously known," says astronomer Tony Farnham, from the University of Maryland (UMD). "We make the assumption that comet BB was probably active even farther out, but we just didn't see it before this. What we don't know yet is if there's some cut-off point where we can start to see these things in cold storage before they become active."

The research has been published in the Planetary Science Journal.