"A new kind of COVID-19 vaccine could be available as soon as this summer," reports NPR: It's what's known as a protein subunit vaccine. It works somewhat differently from the current crop of vaccines authorized for use in the U.S. but is based on a well-understood technology and doesn't require special refrigeration.

In general, vaccines work by showing people's immune systems something that looks like the virus but really isn't. Consider it an advance warning; if the real virus ever turns up, the immune system is ready to try to squelch it. In the case of the coronavirus, that "something" is one of the proteins in the virus — the spike protein. The vaccines made by Johnson & Johnson, Moderna and Pfizer contain genetic instructions for the spike protein, and it's up to the cells in our bodies to make the protein itself.

The first protein subunit COVID-19 vaccine to become available will likely come from the biotech company, Novavax. In contrast to the three vaccines already authorized in the U.S., it contains the spike protein itself — no need to make it, it's already made — along with an adjuvant that enhances the immune system's response, to make the vaccine even more protective.

Protein subunit vaccines made this way have been around for a while. There are vaccines on the market for hepatitis B and pertussis based on this technology.
And meanwhile, the article points out, there's also another company — the pharmaceutical giant Sanofi — that's also working on its own protein subunit vaccine against the coronavirus.

The American Heart Association is a research-funding nonprofit. One of its publications, The Journal of the American Heart Association, "has concurred with a previous report by the Heart Rhythm Journal which said close contact with an iPhone 12 affected certain implantable cardiac devices," writes Apple Insider. As with that report, the American Heart Association says the effect are solely when the iPhone is on or very near the implant... "Our study demonstrates that magnet reversion mode may be triggered when the iPhone 12 Pro Max is placed directly on the skin over an implantable cardiac device and thus has the potential to inhibit lifesaving therapies," say the report writers in the Journal of the American Heart Association. The testing involved placing the iPhone 12 Pro Max in very close proximity to a series of 11 different pacemakers and defibrillators... The degree of interference did vary across the testing, but all devices were affected. The report says that "the iPhone 12 Pro Max was able to trigger magnetic reversion mode at a distance up to 1.5cm [0.6 inches]."

"Apple Inc, has an advisory stating that the newer generation iPhone 12 does not pose a greater risk for magnet interference when compared to the older generation iPhones," notes the report. "However, our study suggests otherwise as magnet response was demonstrated in 3/3 cases in vivo..."

In January 2021, Apple updated its MagSafe support document to recommend that users keep the iPhone 12 six inches away from any medical implants.

A long read in Wired argues that the mRNA vaccine revolution is just beginning.

CNN explains why scientists are so excited: When the final Phase 3 data came out last November showing the mRNA vaccines made by Pfizer/BioNTech and Moderna were more than 90% effective, Dr. Anthony Fauci had no words. He texted smiley face emojis to a journalist seeking his reaction. This astonishing efficacy has held up in real-world studies in the U.S., Israel and elsewhere. The mRNA technology developed for its speed and flexibility as opposed to expectations it would provide strong protection against an infectious disease has pleased and astonished even those who already advocated for it...

This approach that led to remarkably safe and effective vaccines against a new virus is also showing promise against old enemies such as HIV, and infections that threaten babies and young children, such as respiratory syncytial virus and metapneumovirus. It's being tested as a treatment for cancers, including melanoma and brain tumors. It might offer a new way to treat autoimmune diseases. And it's also being checked out as a possible alternative to gene therapy for intractable conditions such as sickle cell disease.
In fact, Moderna is already working on personalized cancer vaccines, the article points out — and that's just the beginning. Two researchers whose technology underlies both the Modern and BioNTech/Pfizer vaccines are now also working on two vaccines against HIV, another one to prevent genital herpes, and two targeting influenza, including a so-called universal influenza vaccine that could protect against rapidly mutating flu strains, possibly offering years of protection with a single shot.

And researchers have also studied mRNA vaccines to fight Ebola, Zika, rabies and cytomegalovirus.

Type "vaccines" into Amazon's search bar, and its auto-complete suggests "are dangerous" for your search. But that's just part of a larger problem, points out Fast Company (in an article shared by Slashdot reader tedlistens).

For example, Amazon's search results are touting as "best sellers!" many books with some very bad science: Offered by small publishers or self-published through Amazon's platform, the books rehearse the falsehoods and conspiracy theories that fuel vaccine opposition, steepening the impact of the pandemic and slowing a global recovery. They also illustrate how the world's biggest store has become a megaphone for anti-vaccine activists, medical misinformers, and conspiracy theorists, pushing dangerous falsehoods in a medium that carries more apparent legitimacy than just a tweet.

"Without question, Amazon is one of the greatest single promoters of anti-vaccine disinformation, and the world leader in pushing fake anti-vaccine and COVID-19 conspiracy books," says Peter Hotez, a pediatrician and vaccine expert at the Baylor College of Medicine. For years, journalists and researchers have warned of the ways fraudsters, extremists, and conspiracy theorists use Amazon to earn cash and attention. To Hotez, who has devoted much of his career to educating the public about vaccines, the real-world consequences aren't academic. In the U.S. and elsewhere, he says, vaccination efforts are now up against a growing ecosystem of activist groups, foreign manipulators, and digital influencers who "peddle fake books on Amazon...."

Gradually, Amazon has taken a tougher approach to content moderation, and to a seemingly ceaseless onslaught of counterfeits, fraud, defective products, and toxic speech... Despite its sweeps, however, Amazon is still flooded with misinformation, and helping amplify it too: A series of recent studies and a review by Fast Company show the bookstore is boosting misinformation around health-related terms like "autism" or "covid," and nudging customers toward a universe of other conspiracy theory books.

In one audit first published in January, researchers at the University of Washington surveyed Amazon's search results for four dozen terms related to vaccines. Among 38,000 search results and over 16,000 recommendations, they counted nearly 5,000 unique products containing misinformation, or 10.47% of the total. For books, they found that titles deemed misinformative appeared higher in search results than books that debunked their theories. "Overall, our audits suggest that Amazon has a severe vaccine/health misinformation problem exacerbated by its search and recommendation algorithms," write Prerna Juneja and Tanushee Mitra in their paper, presented last month at the CHI Conference on Human Factors in Computing Systems. "Just a single click on an anti-vaccine book could fill your homepage with several other similar anti-vaccine books..." Like any products on Amazon, or any content across social media platforms, anti-vaccine titles also benefit from an algorithmically-powered ranking system. And despite the company's aggressive efforts to battle fraud, it's a system that's still easily manipulated through false reviews...

Much of the uproar about misinformation has focused on Facebook, YouTube, and Twitter, but Amazon's role deserves more attention, says Marc Tuters, an assistant professor of new media at the University of Amsterdam, who helped lead the Infodemic.eu study. The retailer sells half of all the books in the U.S. and its brand is highly trusted by consumers.

"It's kind of embarrassing to say, but the social media app TikTok figured out I had ADHD before I did," writes 23-year-old Australian journalist Matilda Boseley in The Guardian.

"For 23 years my parents, my teachers, my doctor, my psychologist and my own brain all missed the warning signs, yet somehow it only took that app's algorithm a few days to accidentally diagnose me..." Growing up I had always had a nagging feeling that everyone else in the world was coping better than I was. Somehow they could remember appointments and deadlines, they had the discipline to keep an updated planner and they didn't drift off daydreaming in the middle of important conversations... I just felt like there were 10 TVs constantly switched on in my head, and with so much going on, all the small things would fall through the cracks. It wasn't until I downloaded TikTok that I truly considered I might have the disorder.

See, the app is based around the "for you" page which curates a stream of videos for you. It starts out pretty generic, but as you "like" some videos, and quickly scroll past others, the app's algorithm builds a profile of you and your interests. And that profile is scarily accurate sometimes. It genuinely knew me better than I knew myself. What I think happened is that the algorithm noticed that every time a video titled something like "Five little known signs of ADHD in women" showed up on my feed I would watch it, fascinated, all the way to the end.

So, like the dystopian capitalism machine it is, the app showed me more and more of these videos desperate to keep me on the app and extract every possible advertising cent my eyeballs could buy. But, as a side effect, all of a sudden I was seeing ADHD content made by women and for women, for the very first time. It was like someone putting everything that always felt weird in my brain into words. Forgetting something exists if you can't see it could be a problem with "object permanence". Being unable to stand up and tidy my apartment, despite desperately wanting to, might not be laziness; it could be "executive dysfunction". Suddenly it occurred to me, maybe I wasn't somehow just "worse at being a person" than everyone else. Maybe I simply didn't have enough dopamine in my brain. I can't overstate how liberating that felt.

So I booked a doctor's appointment, and three referrals, four months and about $700 later my new psychiatrist looked straight into the webcam and said: "Yes, I think you clearly have ADHD and you've had it for your whole life." I cried from joy when he said it.

Mental health experts told me it wasn't actually that surprising that hearing first-hand accounts of neurodivergence is what finally made the pin drop. In fact, Beyond Blue's lead clinical advisor Dr Grant Blashki said social media could be an extraordinarily powerful tool for increasing what the medical community refer to as "mental health literacy". In fact "learning you have ADHD on TikTok" is now such a common phenomenon that it's become its own meme on the app. There isn't any hard and fast data on the phenomenon but just from my own experience, since telling my friends about my diagnosis, no less than four people have come back to me saying they reckon they might have it too...

At the end of the day I am so grateful for TikTok, and the creators that make ADHD videos. That algorithm has profoundly changed my life, undoubtedly for the better.

"Earthquakes shouldn't occur more than 300 kilometers below Earth's surface, according to most geophysical models," reports Science magazine. "Yet they commonly do — a phenomenon that has mystified seismologists for decades."

Slashdot reader sciencehabit shares their report on one possible explanation: that water carried by the tectonic plates shoved beneath continents "could be triggering these deep temblors." The find may also explain another marvel: why a huge number of fist-size diamonds form at this depth...

Steven Shirey, a geochemist at the Carnegie Institution for Science...and his team took a closer look at how water might make its way down deep... Regardless of depth, Shirey and his team found that once rocks in the slabs reached temperatures above 580 degrees C, they were less able to hold water. As that water flooded out of the slab, it weakened the surrounding rocks and triggered quakes, Shirey and his colleagues report in AGU Advances. This water, typically chock-full of dissolved minerals, would also be available to fuel diamond formation...

"The temperature tells the story," says Douglas Wiens, a seismologist at Washington University in St. Louis who was not involved in the new study. If the tectonic slab starts out hot, as it would if the rocks are relatively young, he says, the plate will dehydrate at depths between 100 and 250 kilometers and thus won't carry water far enough down to generate deep quakes. But if rocks in the sinking slab are old and relatively cool, water will stay locked inside the sinking slab for a longer time, persisting there until it is released at depths of 300 to 500 kilometers or more.

Further work in both the lab and the field will be needed to fully understand the relationships between water released from sinking slabs and deep earthquakes, Wiens says. In the meantime, he says, it's clear that diamonds that form at those depths, imperfections and all, will be critical to teasing out the details of the story.

Slashdot reader DevNull127 writes: Documents filed by Florida's health department now "confirm two of the core aspects" of a whistleblower complaint filed by fired data manager Rebekah Jones, the Miami Herald reported Friday. "Sworn affidavits from Department of Health leaders acknowledge Jones' often-denied claim that she was told to remove data from public access after questions from the Miami Herald."

And they also report a position statement from the department (filed August 17th) acknowledging something even morning damning. While a team of epidemiologists at the Department of Health had developed data for the state's plan to re-open — their findings were never actually incorporated into that plan.

Reached for comment, a spokesperson for governor Ron DeSantis still insisted to the Herald that "every action taken by Governor DeSantis was data-driven and deliberate."
From the article: But when the Herald requested the data, data analysis, or data model related to reopening under Florida's open records law, the governor's office responded that there were no responsive records... Secrecy was a policy. Staffers were told not to put anything about the pandemic response into writing, according to four Department of Health employees who spoke on the condition of anonymity... Emails and texts reviewed by the Herald show the governor's office worked in coordination with Department of Health "executive leadership" to micromanage everything about the department's public response to the pandemic, from information requests from the press to specific wording and color choice on the Department of Health website and data dashboard. They slow-walked responses to questions on important data points and public records, initially withholding information and data on deaths and infections at nursing homes, state prisons and schools, forcing media organizations to file or threaten lawsuits. Important information that had previously been made public was redacted from medical examiner accounts of COVID-19 fatalities.

At one point the state mischaracterized the extent of Florida's testing backlog by over 50 percent — skewing the information about how many people were getting sick each day — by excluding data from private labs, a fact that was only disclosed in response to questions from the press. Emails show that amid questions about early community spread, data on Florida's earliest potential cases — which dated back to late December 2019 — were hidden from the public by changing "date range of data that was available on the dashboard."

Department of Health staffers interviewed by the Herald described a "hyper-politicized" communications department that often seemed to be trying to match the narrative coming from Washington.
The Herald's article also "delved into the details of the department's operation," writes DevNull127 : For example, the whistleblower complaint of Rebekah Jones quotes the state's deputy health secretary as telling her pointedly that "I once had a data person who said to me, 'you tell me what you want the numbers to be, and I'll make it happen.'"

Or, as Jones later described that interaction to her mother, "They want me to put misleading data up to support that dumb f***'s plan to reopen. And more people are gonna die because [of] this and that's not what I agreed to."

Last Friday the health department's Office of the Inspector General announced they'd found "reasonable cause" to open an investigation into decisions and actions by Department of Health leadership that could "represent an immediate injury to public health."
Meanwhile, Florida officials confirmed Friday night that their health department "will no longer update its Covid-19 dashboard and will suspend daily case and vaccine reports," according to the New York Times. "Officials will instead post weekly updates, becoming the first U.S. state to move to such an infrequent publishing schedule."

Jones had been using that data to continue running her own online dashboard, and posted Friday in lieu of data that the dashboard's operation would now be interrupted "as I work to reformat the website to adjust for these changes...." But she promised to keep trying to help the people of Florida "in whatever capacity I can with the limitations the Department of Health is now putting on public access to this vital health information."

On Monday, NASA's Juno spacecraft will come within 645 miles of the surface of Jupiter's largest moon, Ganymede. "The flyby will be the closest a spacecraft has come to the solar system's largest natural satellite since NASA's Galileo spacecraft made its penultimate close approach back on May 20, 2000," reports Phys.Org. From the report: Along with striking imagery, the solar-powered spacecraft's flyby will yield insights into the moon's composition, ionosphere, magnetosphere, and ice shell. Juno's measurements of the radiation environment near the moon will also benefit future missions to the Jovian system. Ganymede is bigger than the planet Mercury and is the only moon in the solar system with its own magnetosphere -- a bubble-shaped region of charged particles surrounding the celestial body.

Juno's science instruments will begin collecting data about three hours before the spacecraft's closest approach. Along with the Ultraviolet Spectrograph (UVS) and Jovian Infrared Auroral Mapper (JIRAM) instruments, Juno's Microwave Radiometer's (MWR) will peer into Ganymede's water-ice crust, obtaining data on its composition and temperature. Signals from Juno's X-band and Ka-band radio wavelengths will be used to perform a radio occultation experiment to probe the moon's tenuous ionosphere (the outer layer of an atmosphere where gases are excited by solar radiation to form ions, which have an electrical charge).

Towns and cities across Scotland would be devastated if the country's coastline was hit by a tsunami of the kind that happened 8,200 years ago, according to an academics' study. From a report: While about 370 miles of Scotland's northern and eastern coastline were affected when the Storegga tsunami struck, the study suggests a modern-day disaster of the same magnitude would have worse consequences.

The researchers at the universities of Sheffield, St Andrews and York attributed this to denser human populations and higher sea levels that could potentially destroy seafront and port areas of Arbroath, Stonehaven, Aberdeen, Inverness and Wick, all of which have significant built-up areas less than 10 metres above sea level and directly face the sea. The study which maps the impact of the ancient tsunami for the first time, used modelling to estimate how far the wave would have travelled inland. The estimates suggest the water could have encroached up to 18 miles inland. That distance today would probably leave a town such as Montrose, which overlooks a tidal lagoon and has a population of 12,000, completely devastated.

NASA is sending water bears and bobtail squid to the International Space Station, "as NASA researchers attempt to learn more about how the conditions of spaceflight can affect biological organisms and, by extension, future astronauts," writes Joe Hernandez via NPR. From the report: Tardigrades are microscopic organisms better known as "water bears" because of their shape and the fact that they commonly live in the water. (They have also been called, endearingly, "moss piglets.") Water bears can survive in conditions that would prove fatal for most other animals, such as exposure to extreme temperatures, pressure, and radiation. The fact that they are basically indestructible, according to NASA, makes them the perfect test subjects for an experiment about the effects of spaceflight on biological survival.

Thousands of microbes live inside the human body and work to keep us healthy. But scientists don't have a clear picture of how microgravity -- which allows the kind of floating weightlessness experienced by astronauts when they travel into space -- affects those microbes. That is the subject of an ongoing NASA research program called the Understanding of Microgravity on Animal-Microbe Interactions, or UMAMI. Scientists will study whether microgravity has an impact on the relationship between newly hatched bobtail squid, or Euprymna scolopes, and their symbiotic bacterium, Vibrio fischeri. The goal is to use what they learn about the relationship between squid and the microbes to help better prepare astronauts for lengthy space missions and preserve their health while they're out there.

An anonymous reader quotes a report from The New York Times: Researchers believe they've now pinpointed a previously unknown planetary-scale reset that occurred about 19 million years ago. This extinction event transpired in the world's oceans, and decimated shark populations. The boneless fishes still have not recovered from the damage, the team suggests in a paper published Thursday in Science. Scales cover the bodies -- and even the eyeballs -- of sharks. Known as "dermal denticles," these scales function like protective armor and their ridges also reduce drag as the animals swim, said Elizabeth C. Sibert, an oceanographer and paleontologist at Yale University. These scales are microscopic -- each one is only about the width of a human hair -- but sharks slough off about 100 denticles for each tooth they lose, making them common in the fossil record. This abundance makes them valuable to scientists seeking to understand the past, said Paul Harnik, a paleobiologist at Colgate University, not involved in the research. "It's a sheer numbers game."

In 2015, Dr. Sibert received a box of mud spanning about 40 million years of history. The reddish clay, extracted from two sediment cores that had been drilled deep into the Pacific Ocean seafloor, contained fish teeth, shark denticles and other marine microfossils. Using a microscope and a very fine paintbrush, Dr. Sibert picked through the two sediments and counted the number of fossils in samples separated in time by several hundred thousand years. About halfway through her data set, Dr. Sibert spotted an abrupt change in the fossil record. Nineteen million years ago, the ratio of shark denticles to fish teeth changed drastically: Samples older than that tended to contain roughly one denticle for every five fish teeth (a ratio of about 20 percent), but more recent samples had ratios closer to 1 percent. That meant that sharks suddenly became much less common, relative to fish, during an era known as the early Miocene, Dr. Sibert concluded. Dr. Sibert and her collaborators, in an earlier study using the same data set, had also found that sharks declined in abundance by roughly 90 percent about 19 million years ago. These declines in relative and absolute shark abundance suggest that something happened to shark populations about 19 million years ago, Dr. Sibert concluded.

But there was still the question of whether a true extinction occurred, she said. "We wanted to know if the sharks went extinct, or if they just became less prominent." To test the idea of an extinction, Dr. Sibert recruited Leah D. Rubin, a marine scientist then at the College of the Atlantic in Maine. Together, they developed a framework to identify distinct groups of denticles. The researchers settled on 19 denticle traits -- such as their shape and the orientation of their ridges. Dr. Sibert and Ms. Rubin sorted roughly 1,300 denticles into 88 groups. These groups don't correspond exactly to shark species, but seeing more groups is an indicator that a shark population is more diverse, the researchers proposed. Of the 88 denticle groups initially present before 19 million years ago, only nine persisted afterward. The reduction in shark diversity suggests that they experienced an extinction around that time, Dr. Sibert and Ms. Rubin concluded. In fact, this event was probably even more cataclysmic to sharks than the dinosaur-killing asteroid impact that occurred 66 million years ago, they said. "There were just a small fraction that survived into this post-extinction world," Dr. Sibert said. The researchers have no idea what caused this massive die-off. "There were no significant climatic changes in the early Miocene, and there's no evidence of an asteroid impact around that time," the report says.

sciencehabit shares a report from Science Magazine: Venus can no longer wait. NASA will send two new robotic missions to Earth's hothouse twin, the agency's new administrator, Bill Nelson, announced this afternoon at his "State of NASA" speech here at the agency's headquarters. The missions, together costing up to $1 billion, mark NASA's first visit to the planet since the early 1990s, whereas nearby Mars has seen a host of robotic visitors. They're expected to launch by the decade's end.

The scientific case for exploring Venus has long been strong. No planet has more to say about how Earth came to be. Mars is tiny and frozen, its heat and atmosphere largely lost to space long ago. Venus could host active volcanoes, and it may have once featured oceans and continents, which are critical to the evolution of life. Plate tectonics roughly like Earth's might have held sway there, or might be starting today, hidden under the clouds. Venus also proves by example that orbiting within a star's "habitable zone" doesn't guarantee a planet is suitable for life. Understanding how Venus's atmosphere went bad and turned into a runaway greenhouse, boiling away any oceans and baking the surface, could help astronomers studying other solar systems distinguish truly Earth-like exoplanets from our evil twins.

The James Webb Space Telescope, the largest science observatory to ever be placed into space, won't launch as scheduled on Halloween this year due to a "combination of different factors." The new launch date is expected to be pushed into November or possibly early December. Ars Technica reports: During a press briefing with reporters on Tuesday, the telescope's director for launch services, Beatriz Romero, said that there are a "combination of different factors" to consider when setting a new launch date. These factors include shipment of the telescope, the readiness of the Ariane 5 rocket, and the readiness of the spaceport in South America as well. Romero said she did not expect to identify a new launch date until later this summer or early fall.

NASA plans to ship the telescope to the launch site by boat late this summer. (NASA is keeping precise plans vague due to concerns about piracy at sea. Seriously.) The space agency's chief of science, Thomas Zurbuchen, said Tuesday that "we don't have a lot of reserve" left in the schedule to prepare for shipment. However, he added that NASA and Webb's primary contractor, Northrop Grumman, are close to folding up the telescope and putting it into a shipping container. He said that this should happen toward the "end of August." The launch campaign, which begins when the telescope arrives in French Guiana, requires 55 days. Asked whether this means that Webb will not launch until mid-November at the earliest, Zurbuchen said this assessment was correct.

The rocket is also not ready. The Ariane 5 booster, a venerable rocket in service for more than 25 years, has been grounded since August 2020 due to a payload fairing issue. However, officials with Arianespace, which manages launch for the Ariane 5, said the fairing issue's cause has been diagnosed and addressed with a redesign. Two Ariane 5 launches are scheduled before Webb's launch to ensure that the fairing issue has been fixed. (Those launches are scheduled for July and August, but delays are possible.) Finally, there are concerns about the spaceport itself, where operations have been limited by COVID-19. Vaccines are not yet widely available in French Guiana, and officials have said that if virus activity worsens, it could further slow operations.

A user shares a report from ScienceAlert: The inevitable has occurred. A piece of space debris too small to be tracked has hit and damaged part of the International Space Station -- namely, the Canadarm2 robotic arm. The instrument is still operational, but the object punctured the thermal blanket and damaged the boom beneath. It's a sobering reminder that the low-Earth orbit's space junk problem is a ticking time bomb. Canadarm2 -- formally known as the Space Station Remote Manipulator System (SSRMS), designed by the Canadian Space Agency -- has been a fixture on the space station for 20 years. It's a multi-jointed titanium robotic arm that can assist with maneuvering objects outside the ISS, including cargo shuttles, and performing station maintenance.

It's unclear exactly when the impact occurred. The damage was first noticed on 12 May, during a routine inspection. NASA and the CSA worked together to take detailed images of and assess the damage. "Despite the impact, results of the ongoing analysis indicate that the arm's performance remains unaffected," the CSA wrote in a blog post. "The damage is limited to a small section of the arm boom and thermal blanket. Canadarm2 is continuing to conduct its planned operations." Robotics operations on the ISS using the Canadarm2 will continue as planned for the near future, the CSA said. But both space agencies will continue to gather data in order to perform an analysis of the event, both to understand how it occurred, and to assess future risk.

Electrical engineers at the University of California San Diego developed a technology that improves the resolution of an ordinary light microscope so that it can be used to directly observe finer structures and details in living cells. Phys.Org reports: "This material converts low resolution light to high resolution light," said Zhaowei Liu, a professor of electrical and computer engineering at UC San Diego. "It's very simple and easy to use. Just place a sample on the material, then put the whole thing under a normal microscope -- no fancy modification needed." The work, which was published in Nature Communications, overcomes a big limitation of conventional light microscopes: low resolution. Light microscopes are useful for imaging live cells, but they cannot be used to see anything smaller. Conventional light microscopes have a resolution limit of 200 nanometers, meaning that any objects closer than this distance will not be observed as separate objects. And while there are more powerful tools out there such as electron microscopes, which have the resolution to see subcellular structures, they cannot be used to image living cells because the samples need to be placed inside a vacuum chamber.

The technology consists of a microscope slide that's coated with a type of light-shrinking material called a hyperbolic metamaterial. It is made up of nanometers-thin alternating layers of silver and silica glass. As light passes through, its wavelengths shorten and scatter to generate a series of random high-resolution speckled patterns. When a sample is mounted on the slide, it gets illuminated in different ways by this series of speckled light patterns. This creates a series of low resolution images, which are all captured and then pieced together by a reconstruction algorithm to produce a high resolution image. The researchers tested their technology with a commercial inverted microscope. They were able to image fine features, such as actin filaments, in fluorescently labeled Cos-7 cells -- features that are not clearly discernible using just the microscope itself. The technology also enabled the researchers to clearly distinguish tiny fluorescent beads and quantum dots that were spaced 40 to 80 nanometers apart. The findings appear in the journal Nature Communications.

Liu's team previously published a paper showing that his technology is also capable of imaging with ultra-high axial resolution (about 2 nanometers). They are now working on combining the two together.

Last fall, with the Medici Chapel in Florence operating on reduced hours because of Covid-19, scientists and restorers completed a secret experiment: They unleashed grime-eating bacteria on the artist's masterpiece marbles. From a report: As early as 1595, descriptions of stains and discoloration began to appear in accounts of a sarcophagus in the graceful chapel Michelangelo created as the final resting place of the Medicis. In the ensuing centuries, plasters used to incessantly copy the masterpieces he sculpted atop the tombs left discoloring residues. His ornate white walls dimmed. Nearly a decade of restorations removed most of the blemishes, but the grime on the tomb and other stubborn stains required special, and clandestine, attention. In the months leading up to Italy's Covid-19 epidemic and then in some of the darkest days of its second wave as the virus raged outside, restorers and scientists quietly unleashed microbes with good taste and an enormous appetite on the marbles, intentionally turning the chapel into a bacterial smorgasbord. "It was top secret," said Daniela Manna, one of the art restorers.

On a recent morning, she reclined -- like Michelangelo's allegorical sculptures of Dusk and Dawn above her -- and reached into the shadowy nook between the chapel wall and the sarcophagus to point at a dirty black square, a remnant showing just how filthy the marble had become. She attributed the mess to one Medici in particular, Alessandro Medici, a ruler of Florence, whose assassinated corpse had apparently been buried in the tomb without being properly eviscerated. Over the centuries, he seeped into Michelangelo's marble, the chapel's experts said, creating deep stains, button-shaped deformations, and, more recently, providing a feast for the chapel's preferred cleaning product, a bacterium called Serratia ficaria SH7. "SH7 ate Alessandro," Monica Bietti, former director of the Medici Chapels Museum, said as she stood in front of the now gleaming tomb, surrounded by Michelangelos, dead Medicis, tourists and an all-woman team of scientists, restorers and historians. Her team used bacteria that fed on glue, oil and apparently Alessandro's phosphates as a bioweapon against centuries of stains.

Coronavirus variants with clunky, alphanumeric names have now been assigned the letters of the Greek alphabet to simplify discussion and pronunciation while avoiding stigma. From a report: The World Health Organization revealed the new names on Monday amid criticism that those given by scientists to strains such as the South African variant -- which goes by multiple names including B.1.351, 501Y.V2 and 20H/501Y.V2 -- were too complicated. Since the pandemic began, the names people have used to describe the virus have provoked controversy. Former U.S. President Donald Trump called the new coronavirus "the China virus" and other monikers, raising concern he was using the names as a political weapon to shift blame to a rival nation. The WHO, which has urged people not to use language to advance COVID-19 profiling of people or nationalities, has also said people should avoid using country names in association with emerging variants.

The four coronavirus variants considered of concern by the U.N. agency and known generally by the public as the UK, South Africa, Brazil and India variants have now been assigned the Greek letters Alpha, Beta, Gamma and Delta, respectively, according to the order of their detection. Other variants of interest continue down the alphabet.

New laws in Maryland and Montana are the first in the nation to restrict law enforcement's use of genetic genealogy, the DNA matching technique that in 2018 identified the Golden State Killer, in an effort to ensure the genetic privacy of the accused and their relatives. From a report: Beginning on Oct. 1, investigators working on Maryland cases will need a judge's signoff before using the method, in which a "profile" of thousands of DNA markers from a crime scene is uploaded to genealogy websites to find relatives of the culprit. The new law, sponsored by Democratic lawmakers, also dictates that the technique be used only for serious crimes, such as murder and sexual assault. And it states that investigators may only use websites with strict policies around user consent. Montana's new law, sponsored by a Republican, is narrower, requiring that government investigators obtain a search warrant before using a consumer DNA database, unless the consumer has waived the right to privacy.

The laws "demonstrate that people across the political spectrum find law enforcement use of consumer genetic data chilling, concerning and privacy-invasive," said Natalie Ram, a law professor at the University of Maryland who championed the Maryland law. "I hope to see more states embrace robust regulation of this law enforcement technique in the future." Privacy advocates like Ms. Ram have been worried about genetic genealogy since 2018, when it was used to great fanfare to reveal the identity of the Golden State Killer, who murdered 13 people and raped dozens of women in the 1970s and '80s. After matching the killer's DNA to entries in two large genealogy databases, GEDmatch and FamilyTreeDNA, investigators in California identified some of the culprit's cousins, and then spent months building his family tree to deduce his name -- Joseph James DeAngelo Jr. -- and arrest him.

Slashdot reader 4wdloop shared this report from NVIDIA's blog, joking that maybe this is where all NVIDIA's chips are going: It will help piece together a 3D map of the universe, probe subatomic interactions for green energy sources and much more. Perlmutter, officially dedicated Thursday at the National Energy Research Scientific Computing Center (NERSC), is a supercomputer that will deliver nearly four exaflops of AI performance for more than 7,000 researchers. That makes Perlmutter the fastest system on the planet on the 16- and 32-bit mixed-precision math AI uses. And that performance doesn't even include a second phase coming later this year to the system based at Lawrence Berkeley National Lab.

More than two dozen applications are getting ready to be among the first to ride the 6,159 NVIDIA A100 Tensor Core GPUs in Perlmutter, the largest A100-powered system in the world. They aim to advance science in astrophysics, climate science and more. In one project, the supercomputer will help assemble the largest 3D map of the visible universe to date. It will process data from the Dark Energy Spectroscopic Instrument (DESI), a kind of cosmic camera that can capture as many as 5,000 galaxies in a single exposure. Researchers need the speed of Perlmutter's GPUs to capture dozens of exposures from one night to know where to point DESI the next night. Preparing a year's worth of the data for publication would take weeks or months on prior systems, but Perlmutter should help them accomplish the task in as little as a few days.

"I'm really happy with the 20x speedups we've gotten on GPUs in our preparatory work," said Rollin Thomas, a data architect at NERSC who's helping researchers get their code ready for Perlmutter. DESI's map aims to shed light on dark energy, the mysterious physics behind the accelerating expansion of the universe.

A similar spirit fuels many projects that will run on NERSC's new supercomputer. For example, work in materials science aims to discover atomic interactions that could point the way to better batteries and biofuels. Traditional supercomputers can barely handle the math required to generate simulations of a few atoms over a few nanoseconds with programs such as Quantum Espresso. But by combining their highly accurate simulations with machine learning, scientists can study more atoms over longer stretches of time. "In the past it was impossible to do fully atomistic simulations of big systems like battery interfaces, but now scientists plan to use Perlmutter to do just that," said Brandon Cook, an applications performance specialist at NERSC who's helping researchers launch such projects. That's where Tensor Cores in the A100 play a unique role. They accelerate both the double-precision floating point math for simulations and the mixed-precision calculations required for deep learning.

"Traveling in a space plane is a lot like traveling in a regular plane, except for the middle part," quips Bloomberg Business Week: After reaching cruising altitude, the pilot hits the rocket boosters and blasts the aircraft to the edge of space at more than 9,000 mph, or about 12 times the speed of sound. The plane travels at that speed for about 15 minutes, then glides against the atmosphere to slow itself down, cruising back to Earth to land at a conventional airport.

Venus Aerospace Corp., a startup pursuing a hypersonic space plane, is aiming to use this technique to ferry people from Los Angeles to Tokyo in about an hour.

The company was started by two former Virgin Orbit LLC employees: Sarah "Sassie" Duggleby, a code-writing launch engineer, and her husband, Andrew, who managed launch, payload, and propulsion operations... Venus now has 15 employees, most veterans of the space industry, and has received investment from venture capital firms including Prime Movers and Draper Associates. "Every few decades humans attempt this," says Andrew Duggleby, in a tacit acknowledgment of the idea's repeated failure. "This time it will work...."

Still, flights aren't imminent. The shape of the aircraft is a work in progress, and the company will begin testing three scale models this summer. The Dugglebys, who've secured a small research grant from the U.S. Air Force and are pursuing additional funding from the Department of Defense, expect the project to take a decade or more.