Earlier today at around 11:45 AM EDT, Virgin Orbit successfully launched its first commercial satellites from their LauncherOne rocket, which blasted off from beneath the wing of a Boeing 747. TechCrunch reports: On board, Virgin Orbit carried seven payloads, including the first-ever defense satellite for the Netherlands, as well as cubsats developed by the U.S. Department of Defense for its Rapid Agile Launch initiative. The initiative is seeking to test the viability of flying small spacecraft to space on relatively short notice on launch platforms with increased flexibility, which Virgin Orbit's provides thanks to its ability to take off horizontally from more or less conventional runways. Virgin Orbit also carried two Earth observation satellites for Polish startup SatRevolution, and it will be delivering more in future flights to help build out that company's planned 14-spacecraft constellation.

In January, Virgin Orbit completed its final demonstration mission, reaching orbit for the first time with LauncherOne. That paved the way for this mission, and the company plans to increase the pace and frequency of its commercial missions, with at least one more planned tentatively for later this year and many more in 2022. In terms of payload capacity, Virgin Orbit's Launcher One can carry around 1,100 pounds to low Earth orbit, which compares favorably with the capacity of Rocket Lab's Electron, which can carry around 661 pounds to the same destination.

A team of researchers from Spain, France and the U.S. has found evidence of a glauconitic-like clay on Mars that suggests the planet once had habitable conditions. Phys.Org reports: In their paper published in the journal Nature Astronomy, the group describes their study of clay minerals extracted from Gale Crater by Curiosity rover back in 2016 and what they found. Back in 2016, NASA's Curiosity rover drilled into the Martian surface inside of Gale Crater. The rover then extracted samples of the clay minerals and used its instruments to analyze the material. In this new effort, the researchers have taken a close look at the results of the analysis and found that it very closely resembles glauconitic clays here on Earth.

Glauconite is an iron potassium phyllosilicate mineral. It is almost always found as ovoid shapes in sediment beds, carbonates and sandstones -- formation requires stable conditions over a long period. This is what makes the discovery of a similar clay on Mars so exciting -- it suggests that it likely formed under stable conditions for a long time, perhaps millions of years. And that suggests that for at least one part of Mars, conditions were, to some extent, suitable for life over millions of years. [...] The researchers note that their findings are not evidence of life on Mars, but suggest that there was a time during which conditions on the surface were favorable for its presence.

The amount of water in the atmosphere of Venus is so low that even the most drought-tolerant of Earth's microbes wouldn't be able to survive there, a new study has found. However, the researchers looked at data from other planets too and found that the clouds of Jupiter do provide sufficient water activity to theoretically support life. Space.com reports: The new study looked at measurements from probes that flew through the atmosphere of Venus and acquired data about temperature, humidity and pressure in the thick sulphuric acid clouds surrounding the planet. From these values, the scientists were able to calculate the so-called water activity, the water vapor pressure inside the individual molecules in the clouds, which is one of the limiting factors for the existence of life on Earth. The findings are likely a disappointment for the Venus research community, which was invigorated last September by the discovery of phosphine, a compound made of atoms of phosphorus and hydrogen that on Earth can be associated with living organisms, in Venus' atmosphere. At that time, researchers suggested the phosphines may be produced by microorganisms residing in those clouds. On Earth [...] microorganisms can survive and proliferate in droplets of water in the atmosphere when temperatures allow. However, the findings of the new study, based on data from several Venus probes, leave zero chance of anything living in the clouds of Venus [...].

However, the researchers looked at data from other planets too and found that the clouds of Jupiter do provide sufficient water activity to theoretically support life. Data collected by the Galileo probe at altitudes between 26 and 42 miles (42 and 68 kilometers) above the surface of the gas giant suggest the water activity value to sit at 0.585, just above the survivable threshold. Temperatures in this region are also just about survivable, at around minus 40 degrees F. High levels of ultraviolet radiation or lack of nutrients could, however, prevent that potential life from thriving, the researchers said, and completely new measurements would be needed to find whether it actually could be there or not.

In January last year, astronomers definitively observed, for the first time, a black hole swallowing a dead star, like a raven devouring roadkill. Then 10 days later, they saw the same act of scavenging happen again in a different, distant sector of the cosmos. From a report: Those triumphs, reported in a paper published on Tuesday in Astrophysical Journal Letters, are the latest in the still nascent field of gravitational astronomy, which is detecting the literal stretching and scrunching of space-time caused by some of the most cataclysmic events in the universe. "It's the first time that we've actually been able to detect a neutron star and a black hole colliding with each other anywhere in the universe," said Patrick Brady, a professor of physics at the University of Wisconsin-Milwaukee who serves as the spokesman for the LIGO Scientific Collaboration. Further reading: For the first time, astronomers see a black hole eating a neutron star.

An anonymous reader quotes a report from Scientific American: Behold the highest-resolution image of atoms ever seen. Cornell University researchers captured a sample from a crystal in three dimensions and magnified it 100 million times, doubling the resolution that earned the same scientists a Guinness World Record in 2018. Their work could help develop materials for designing more powerful and efficient phones, computers and other electronics, as well as longer-lasting batteries. The researchers obtained the image using a technique called electron ptychography. It involves shooting a beam of electrons, about a billion of them per second, at a target material. The beam moves infinitesimally as the electrons are fired, so they hit the sample from slightly different angles each time -- sometimes they pass through cleanly, and other times they hit atoms and bounce around inside the sample on their way out. Cornell physicist David Muller, whose team conducted the recent study, likens the technique to playing dodgeball against opponents who are standing in the dark. The dodgeballs are electrons, and the targets are individual atoms. Though Muller cannot see the targets, he can see where the "dodgeballs" end up, thanks to advanced detectors. Based on the speckle pattern generated by billions of electrons, machine-learning algorithms can calculate where the atoms were in the sample and what their shapes might be.

Previously, electron ptychography had only been used to image extremely flat samples: those merely one to a few atoms thick. The new study, published in Science, now allows it to capture multiple layers tens to hundreds of atoms thick. That makes the technique much more relevant to materials scientists, who typically study the properties of samples with a thickness of about 30 to 50 nanometers. (That range is smaller than the length your fingernails grow in a minute but many times thicker than what electron ptychography could image in the past.) "They can actually look at stacks of atoms now, so it's amazing," says Andrew Maiden, an engineer at the University of Sheffield in England, who helped develop ptychography but was not involved with the new study. "The resolution is just staggering."

New findings from a team using the international Gemini Observatory and the WIYN 3.5-meter Telescope at Kitt Peak National Observatory suggest that Earth-sized worlds could be lurking undiscovered in binary star systems, hidden in the glare of their parent stars. As roughly half of all stars are in binary systems, this means that astronomers could be missing many Earth-sized worlds. Phys.Org reports: Earth-sized planets may be much more common than previously realized. Astronomers working at NASA Ames Research Center have used the twin telescopes of the international Gemini Observatory, a Program of NSF's NOIRLab, to determine that many planet-hosting stars identified by NASA's TESS exoplanet-hunting mission are actually pairs of starsâ"known as binary starsâ"where the planets orbit one of the stars in the pair. After examining these binary stars, the team has concluded that Earth-sized planets in many two-star systems might be going unnoticed by transit searches like TESS's, which look for changes in the light from a star when a planet passes in front of it. The light from the second star makes it more difficult to detect the changes in the host star's light when the planet transits.

Using the 'Alopeke and Zorro instruments on the Gemini North and South telescopes in Chile and Hawai'i, respectively, the team observed hundreds of nearby stars that TESS had identified as potential exoplanet hosts. They discovered that 73 of these stars are really binary star systems that had appeared as single points of light until observed at higher resolution with Gemini. "With the Gemini Observatory's 8.1-meter telescopes, we obtained extremely high-resolution images of exoplanet host stars and detected stellar companions at very small separations," said Katie Lester of NASA's Ames Research Center, who led this work. Lester's team also studied an additional 18 binary stars previously found among the TESS exoplanet hosts using the NN-EXPLORE Exoplanet and Stellar Speckle Imager (NESSI) on the WIYN 3.5-meter Telescope at Kitt Peak National Observatory, also a Program of NSF's NOIRLab.

After identifying the binary stars, the team compared the sizes of the detected planets in the binary star systems to those in single-star systems. They realized that the TESS spacecraft found both large and small exoplanets orbiting single stars, but only large planets in binary systems. These results imply that a population of Earth-sized planets could be lurking in binary systems and going undetected using the transit method employed by TESS and many other planet-hunting telescopes. Some scientists had suspected that transit searches might be missing small planets in binary systems, but the new study provides observational support to back it up and shows which sizes of exoplanets are affected. The researchers report their findings in a paper via arXiv.

Alcohol is terrible for the human body, yet we've developed a strong taste for it, suggesting that it may bring other kinds of benefits. From a report: Alcoholic intoxication is an abnormal mental state characterized by reduced self-control and various degrees of euphoria or depression, brought about by the temporary impairment of a pretty big chunk of the brain. As the term suggests, it involves the ingestion of a chemical toxin, ethanol, which in small doses makes us happy, more sociable and better at thinking creatively and defusing conflicts. In progressively higher doses, it can lead to degraded motor coordination, slurred speech, violent arguments, maudlin expressions of love, inappropriate touching, injuries, blackouts, property damage and even karaoke. Why do we do it? Historically, scientists have written off our affinity for intoxication as an evolutionary mistake, a method that we've developed for tricking our biological reward system into releasing little shots of pleasure for no good reason. But this is not a satisfying explanation. It should puzzle us more than it does that humans have devoted so much ingenuity and effort to getting drunk.

[...] If alcohol were merely hijacking pleasure centers in the brain, evolution should have figured it out by now and put a firm end to this nonsense. Other vices can plausibly be seen as necessary appetites gone wrong, such as our taste for pornography or junk food. But alcohol is mind-bogglingly dangerous, both physiologically and socially. The fact that our supposedly accidental taste for it has not been eradicated by genetic or cultural evolution means that the cost of indulging in alcohol must be offset by benefits. Evidence from archaeology, history, cognitive neuroscience, psychopharmacology, social psychology, literature and genetics suggests what some of these benefits might be. For instance, the ancient and cross-cultural view of alcohol as a muse is supported by modern psychology: Our ability to think outside the box is enhanced by one or two drinks. This is why artists, poets and writers have long turned to drink. The name of the Anglo-Saxon god of artistic inspiration, Kvasir, literally means "strong ale." This is also why some modern companies that rely upon innovation, like Google, judiciously mix work with alcohol -- by, for instance, providing whiskey rooms where frustrated coders can relax and expand their minds when struggling with a challenging problem.

A mix-and-match approach to Covid vaccines -- using different brands of jab for first and second doses -- gives good protection against the pandemic virus, a UK study has found. From a report: The Com-Cov trial looked at the efficacy of either two doses of Pfizer, two of AstraZeneca, or one of them followed by the other. All combinations worked well, priming the immune system. This knowledge could offer flexibility for vaccine rollout, say experts. The trial results also hint that people who have already received two doses of AstraZeneca vaccine could have a stronger immune response if they were given a different jab as a booster if recommended in the autumn. The UK's deputy chief medical officer, Prof Jonathan Van-Tam, said there was no reason to change the current successful same dose vaccine schedules in the UK, however, given vaccines were in good supply and saving lives. But he says it might be something to look at in the future: "Mixing doses could provide us with even greater flexibility for a booster programme, while also supporting countries who have further to go with their vaccine rollouts, and who may be experiencing supply difficulties."

The most severe heat wave in the history of the Pacific Northwest is nearing its climax. The National Weather Service had predicted it would be "historic, dangerous, prolonged and unprecedented," and it is living up to its billing as it rewrites the record books. From a report: On Sunday, Portland, Ore., soared to its highest temperature in more than 80 years of record-keeping: 112 degrees. This new mark occurred just one day after hitting 108, which had broken the previous all-time record of 107. Seattle surged to 104 degrees Sunday, surpassing the old record of 103. The extraordinary heat swelled north of the international border as Canada saw its highest temperature recorded Sunday afternoon, when Lytton in British Columbia surged to 116 degrees. For perspective, that is just 1 degree from the all-time record in Las Vegas. While temperatures may have peaked Sunday afternoon in a few places, many were expected to turn even hotter on Monday or Tuesday, breaking all-time records (a number of which were initially broken Saturday and/or Sunday).

"Virgin Galactic finally has the federal government's approval to start launching customers into space from New Mexico," reports ABC News: Richard Branson's rocketship company announced the Federal Aviation Administration's updated license on Friday. It's the final hurdle in Virgin Galactic's yearslong effort to send paying passengers on short space hops. The company is working toward three more space test flights this summer and early fall, before opening the rocketship's doors to paying customers. The original plans called for company engineers to launch next to evaluate equipment, followed by a flight with Branson and then a science mission by Italian Air Force officers.

In the meantime, Blue Origin's Jeff Bezos earlier this month announced plans to ride his own rocket into space July 20 from Texas. Virgin Galactic officials acknowledged the growing chatter over whether Branson will try to beat Bezos into space. "Clearly, Sir Richard Branson's flight date has been subject to speculation for some time. At this time we do not have any further details on the upcoming flight dates," company spokeswoman Aleanna Crane wrote in an email...

More than 600 people already have reserved a ride to space. Tickets initially cost $250,000, but the price is expected to go up once Virgin Galactic starts accepting reservations again.

"China has released landing process footage from its Zhurong rover as well as video and sounds of the vehicle roving on Mars," reports Space News: Footage of the entry, descent and landing shows deployment of a supersonic disk-gap-band parachute, separation of the backshell, followed by powered descent, a hazard-avoidance hover phase, and landing... Video of the descent of the Zhurong rover from its landing platform, including sounds made by the vehicle's egress, was included in the release. The sounds were created by the metal on metal interaction of a rack and pinion system and recorded by Zhurong's climate station, which intends to capture sounds of Martian winds... The 240-kilogram Zhurong rover successfully landed in Utopia Planitia on May 14.

The deployment took place late May 21 Eastern, following a week-long series of checks and analysis of the environment. The six-wheeled, solar-powered Zhurong has since covered 236 meters on the Martian surface. An undated panorama shows Zhurong and tracks leading back to the landing platform, along with surface and horizon features...

The rover is part of the Tianwen-1 mission, China's first independent interplanetary mission. Consisting of an orbiter, a lander, and a rover, Tianwen-1 launched in July 2020. It entered Mars orbit February 10. Zhurong is equipped with six science payloads, including a laser-induced breakdown spectroscopy instrument for analysing surface elements and minerals, panoramic and multispectral imagers, a climate station, magnetometer and a ground-penetrating radar. It aims to return data on potential water-ice deposits, weather, topography and geology, complementing science carried out by missions from other space agencies.

The Tianwen-1 orbiter is currently in an 8.2-hour orbit, allowing a pass over Utopia Planitia once per sol to perform a data relay role. Zhurong has a primary mission and design lifetime of 90 sols (92 Earth days). It is currently unknown if Zhurong's mission will be extended beyond this.
Engadget argues that this footage from Mars "is as much about bragging rights as anything. Zhurong is part of China's first truly independent mission to another planet, and the country no doubt wants to highlight its accomplishments in as much detail as possible."

Long-time Slashdot reader schwit1 shares an interesting report from Science Alert: Thunderstorms that roil across the Southern Great Plains of the US are amongst the strongest of such storms on Earth... Their intensity and frequency have been increasing, yet our best climate models still struggle to predict just how and when they'll arise.

To help refine climate models for the Southern Great Plains, paleoclimatologist Christopher Maupin from Texas A&M University and colleagues used oxygen and hydrogen isotopes to track the ferocity of past storms. Water molecules based on elements wielding an additional neutron or two tend to require a little more energy to vaporize, and release more energy as they condense. This leaves a clear signature in the ratios of isotopes separated by rainfall under various conditions. By comparing the results of analyses taken today with historic ratios of hydrogen and oxygen isotopes found trapped by stalactites in Texan caves, the researchers developed an accurate picture of weather events in the past...

Using another set of isotopes, this time measuring those of uranium and thorium, the team dated the stalactites and stalagmites to around the last Ice Age, 30-50 thousand years ago. Measuring the shifts in oxygen and hydrogen isotopes down their lengths allowed the researchers to see the storms cycled from weakly to strongly organized, roughly every thousand years. The more strongly organized the complex of storms becomes, the more intense and damaging they are. They discovered these changes in thunderstorm intensities coincided with well-known, abrupt shifts in global climate, known as Dansgaard-Oeschger events.

The researchers also found these intensity increases coincide with a reduction in rain in southwestern US and greater atmospheric upwelling in the Santa Barbara Basin area. They believe the observed pattern suggests an increased frequency or intensity of the giant global atmospheric waves that drive the weather, called Rossby waves, may be providing the extra lift needed to fuel these greater storms. "Modern anthropogenic climate forcing has increasingly favored an amplification of these synoptic factors," the team wrote in their paper.

"This work will help predict trends of storms in the future," explained geoscientist Courtney Schumacher.

I sometimes talk about "the family of geeks" — how our shared experiences can bring us together.

But if that's true, there's been a death in the family.... Manatee County Administrator Scott Hopes, who is also an epidemiologist, said six unvaccinated employees, including five in the IT department, tested positive for the virus within a two-week period.

The two IT employees who died last week were identified in local media and obituaries as Mary Knight, 58, and Alphonso Cox, 53.

Hopes said that the one IT employee, 23, exposed to the virus who was vaccinated did not get infected. "This particular outbreak demonstrates the effectiveness, I believe, with the vaccine," he said to reporters Monday. "All of the cases were non-vaccinated. They were unvaccinated." He added in a news release, "Individual employees in the IT Department who were known to be fully vaccinated and who were in close proximity of those who were infected did not contract COVID-19."

But even with the outbreak, masks will remain optional for staffers returning this week, with unvaccinated workers being "encouraged but not required, to follow covid-19 prevention measures...." Manatee County, located in southwest Florida, has fully vaccinated 43 percent of its eligible population. The Manatee Board of County Commissioners repealed coronavirus safety requirements last month and strongly recommended that people visiting the County Administration Building "use their best judgment" to protect themselves from a potential spread of the virus...

When the second employee died Thursday, the decision was made to shut down the building the next day so it could be disinfected. "When you have that many cases, and you have a 40 percent fatality rate, you have to worry," Hopes said to Florida Politics. "I would prefer not to have any more employee funerals." Yet the county announced over the weekend that "face masks will be optional for the public and employees inside the facility...."

Funerals and celebration-of-life events for Knight and Cox are scheduled to take place later this week.
Thanks to Slashdot reader luis_a_espinal (a Florida-based software engineer) for sharing the story. Country administrator Hopes is concerned, reports the Sarasota Herald-Tribune, because "Of the first five cases, all were sick enough to be hospitalized or died. That's not the normal COVID variant that we saw last year." And yet... As officials work to control the outbreak, questions have been raised about how far the county can go to keep employees safe — including whether it can inquire about employees' vaccination status, since the recent victims so far have not been fully vaccinated... "We are allowed to ask," Hopes said. "But they don't have to tell us, and whatever their response is, we are not to ask any further." Manatee County School District General Counsel Mitch Teitelbaum said the school district had the same understanding of privacy laws...

[The county-owned seaport] Port Manatee had reported three new cases of COVID-19 on Monday, spurring fears that the virus was continuing to spread among the county's workforce. On Tuesday, port spokeswoman Virginia Zimmerman said the three cases had been an "aberration" and that there are not any additional cases to report. Zimmerman said the port does not inquire about employees' vaccination status, and that the port "encourages, but does not require, staff to be vaccinated."

While the county scrambles to mitigate the spread of the virus, Hopes said many county employees are grieving the loss of their coworkers.

"These weren't just colleagues," Hopes said. "These people have basically lived at work together for 20 years, and this happened quickly."

The New York Times tells the story of Fayçal Ziraoui, a 38-year-old French-Moroccan business consultant who "caused an online uproar" after saying he'd cracked the last two unsolved ciphers of the four attributed to the Zodiac killer in California "and identified him, potentially ending a 50-year-old quest." Maybe because he said he cracked them in just two weeks. Many Zodiac enthusiasts consider the remaining ciphers — Z32 and Z13 — unsolvable because they are too short to determine the encryption key. An untold number of solutions could work, they say, rendering verification nearly impossible.

But Mr. Ziraoui said he had a sudden thought. The code-crackers who had solved the [earlier] 340-character cipher in December had been able to do so by identifying the encryption key, which they had put into the public domain when announcing their breakthrough. What if the killer used that same encryption key for the two remaining ciphers? So he said he applied it to the 32-character cipher, which the killer had included in a letter as the key to the location of a bomb set to go off at a school in the fall of 1970. (It never did, even though police failed to crack the code.) That produced a sequence of random letters from the alphabet. Mr. Ziraoui said he then worked through a half-dozen steps including letter-to-number substitutions, identifying coordinates in numbers and using a code-breaking program he created to crunch jumbles of letters into coherent words...

After two weeks of intense code-cracking, he deciphered the sentence, "LABOR DAY FIND 45.069 NORT 58.719 WEST." The message referred to coordinates based on the earth's magnetic field, not the more familiar geographic coordinates. The sequence zeroed in on a location near a school in South Lake Tahoe, a city in California referred to in another postcard believed to have been sent by the Zodiac killer in 1971.

An excited Mr. Ziraoui said he immediately turned to Z13, which supposedly revealed the killer's name, using the same encryption key and various cipher-cracking techniques. [The mostly un-coded letter includes a sentence which says "My name is _____," followed by a 13-character cipher.] After about an hour, Mr. Ziraoui said he came up with "KAYR," which he realized resembled the last name of Lawrence Kaye, a salesman and career criminal living in South Lake Tahoe who had been a suspect in the case. Mr. Kaye, who also used the pseudonym Kane, died in 2010.

The typo was similar to ones found in previous ciphers, he noticed, likely errors made by the killer when encoding the message. The result that was so close to Mr. Kaye's name and the South Lake Tahoe location were too much to be a coincidence, he thought. Mr. Kaye had been the subject of a report by Harvey Hines, a now-deceased police detective, who was convinced he was the Zodiac killer but was unable to convince his superiors. Around 2 a.m. on Jan. 3, an exhausted but elated Mr. Ziraoui posted a message entitled "Z13 — My Name is KAYE" on a 50,000-member Reddit forum dedicated to the Zodiac Killer.

The message was deleted within 30 minutes.

"Sorry, I've removed this one as part of a sort of general policy against Z13 solution posts," the forum's moderator wrote, arguing that the cipher was too short to be solvable.

NASA has released a new video explaining the complicated, hour-long process required for the Mars rover to take a selfie (which was actually a composite of 62 separate images stitched together).

And meanwhile, CNN reports that its Ingenuity helicopter completed its eighth flight this week, "and even got a software update to fix an annoying issue that impacted some of its previous outings." On its latest outing, Ingenuity flew 525 feet (160 meters) to the south and southeast to a new airfield. This was the copter's third flight of the operations demo phase, in which Ingenuity is proving its usefulness as an aerial scout without interfering with the Perseverance rover's science mission — searching for evidence of ancient life on Mars... Ingenuity continues to do well, and the team is planning for more flights that will push its capabilities. And the helicopter is doing even better now that its troublesome "watchdog" software issue has been fixed. That was deployed before the eighth flight...

Ingenuity is also due for a navigation computer software update that will fix the issue that occurred during the chopper's sixth flight. Images captured by the navigation camera, which feed into the helicopter's navigation computer, had timing delays. Those images help Ingenuity to track its location, among other critical factors during flight. When the incorrect times and images were associated, it caused the chopper to wobble in the air. Ingenuity was able to land safely, but the team wants to prevent the issue from happening again so the chopper doesn't spiral out of control. It's also why the helicopter didn't capture any color images during its last two flights.

Ran Balicer leads an expert Covid-19 advisory panel for the Israeli government. Friday he shared some troubling news with the Wall Street Journal: "The entrance of the Delta variant has changed the transmission dynamics," said Prof. Balicer, who is also the chief innovation officer for Israel's largest health-management organization, Clalit.

About half of adults infected in the outbreak of the Delta variant of Covid-19 in Israel were fully inoculated.

These so-called breakthrough cases — defined as positive Covid-19 test results received at least two weeks after patients receive their final vaccine dose — are broadly expected as the Pfizer vaccine is highly effective but not 100% foolproof, according to Mr. Balicer. Israeli health officials are optimistic that even if the variant does spread, evidence from countries such as the U.K. indicate the vaccine will prevent a large increase in severe illness and hospitalizations that plagued the country's health system in previous outbreaks. Israel has recorded only five severe cases in the past 10 days, Prof. Balicer said, but whether more will emerge is too early to tell....

Dr. Tedros Adhanom Ghebreyesus, director-general of the World Health Organization, said the worrisome variant is now present in 85 countries.
Several countries appear concerned that fully vaccinated people could still spread the Delta variant. Israel's government just reimposed safety measures (including an indoor-mask requirement), according to the Journal. And Sydney, Australia (the country's largest city, housing more than 5 million people) "will enter a hard two-week lockdown on Saturday night..." reports CNN, "as authorities try to contain a fast-spreading outbreak of the highly infectious Delta coronavirus variant." More than a million people in downtown Sydney and the city's eastern suburbs were already under lockdown due to the outbreak, but health authorities said they needed to expand that after more Covid-19 cases were recorded, with exposure sites increasing beyond the initial areas of concern.
Meanwhile, CNBC reports: The World Health Organization on Friday urged fully vaccinated people to continue to wear masks, social distance and practice other Covid-19 pandemic safety measures as the highly contagious delta variant spreads rapidly across the globe. "People cannot feel safe just because they had the two doses. They still need to protect themselves," Dr. Mariangela Simao, WHO assistant director-general for access to medicines and health products, said during a news briefing from the agency's Geneva headquarters. "Vaccine alone won't stop community transmission," Simao added. "People need to continue to use masks consistently, be in ventilated spaces, hand hygiene ... the physical distance, avoid crowding. This still continues to be extremely important, even if you're vaccinated when you have a community transmission ongoing."
CNN reports that the U.S. Centers for Disease Control and Prevention also "warned that there is a small chance a fully vaccinated person could still get infected if they're exposed." "Current data suggest that COVID-19 vaccines authorized for use in the United States offer protection against most variants currently spreading in the United States. However, some variants might cause illness in some people even after they are fully vaccinated," CDC spokesperson Jade Fulce told CNN in an email on Friday. While Covid-19 vaccines are effective, Fulce said no vaccine is "100% effective at preventing illness." And with millions of people getting vaccinated against the virus, some who are fully vaccinated "will still get sick if they are exposed," Fulce said.

"However, people with breakthrough infections may get less severely ill or have a shorter illness than they would have if they had not been vaccinated."

An anonymous reader quotes a report from The New York Times: Researchers have found evidence that a coronavirus epidemic swept East Asia some 20,000 years ago and was devastating enough to leave an evolutionary imprint on the DNA of people alive today. The new study suggests that an ancient coronavirus plagued the region for many years, researchers say. The finding could have dire implications for the Covid-19 pandemic if it's not brought under control soon through vaccination. "It should make us worry," said David Enard, an evolutionary biologist at the University of Arizona who led the study, which was published on Thursday in the journal Current Biology. "What is going on right now might be going on for generations and generations."

Over generations, viruses drive enormous amounts of change in the human genome. A mutation that protects against a viral infection may well mean the difference between life and death, and it will be passed down to offspring. A lifesaving mutation, for example, might allow people to chop apart a virus's proteins. But viruses can evolve, too. Their proteins can change shape to overcome a host's defenses. And those changes might spur the host to evolve even more counteroffensives, leading to more mutations. When a random new mutation happens to provide resistance to a virus, it can swiftly become more common from one generation to the next. And other versions of that gene, in turn, become rarer. So if one version of a gene dominates all others in large groups of people, scientists know that is most likely a signature of rapid evolution in the past.

In recent years, Dr. Enard and his colleagues have searched the human genome for these patterns of genetic variation in order to reconstruct the history of an array of viruses. When the pandemic struck, he wondered whether ancient coronaviruses had left a distinctive mark of their own. He and his colleagues compared the DNA of thousands of people across 26 different populations around the world, looking at a combination of genes known to be crucial for coronaviruses but not other kinds of pathogens. In East Asian populations, the scientists found that 42 of these genes had a dominant version. That was a strong signal that people in East Asia had adapted to an ancient coronavirus. But whatever happened in East Asia seemed to have been limited to that region. The scientists then tried to estimate how long ago East Asians had adapted to a coronavirus. They took advantage of the fact that once a dominant version of a gene starts being passed down through the generations, it can gain harmless random mutations. As more time passes, more of those mutations accumulate. Dr. Enard and his colleagues found that the 42 genes all had about the same number of mutations. That meant that they had all rapidly evolved at about the same time. "This is a signal we should absolutely not expect by chance," Dr. Enard said. They estimated that all of those genes evolved their antiviral mutations sometime between 20,000 and 25,000 years ago, most likely over the course of a few centuries. It's a surprising finding, since East Asians at the time were not living in dense communities but instead formed small bands of hunter-gatherers.

University of Oxford scientists are trialing giving Ivermectin to people with Covid symptoms to see if it can keep them out of hospital. The BBC reports: The Principle study will compare those given the drug to patients receiving the usual NHS care. The drug has become controversial after being promoted for use across Latin America and in South Africa, despite being so far unproven. Previous studies of Ivermectin have generally been small or low quality. Most commonly used to treat parasitic infections such as river blindness, spread by flies, Ivermectin has also been shown to kill viruses in petri dishes in the lab -- although, at much higher doses than would usually be prescribed to people.

Dr Aurora Baluja, an anaesthesiologist and critical care doctor, said Ivermectin was often being given in parts of the world where there are high incidences of parasitic infections. Covid patients who are also fighting a parasitic disease at the same time would be likely to fare worse and that might explains some of its seemingly positive effect. Though there have been some early "promising" results from small and observational studies, Principle joint chief investigator Prof Richard Hobbs said it would be "premature" to recommend Ivermectin for Covid. [...] The Oxford team said they had selected Ivermectin to be included in the trial because it was "readily available globally" and known to be relatively safe (although, like most things, it can be toxic at very high doses). People aged 18-64 with an underlying health condition or experiencing breathlessness, and anyone aged 65 or over, can sign up to the Principle study within 14 days of having Covid symptoms or receiving a positive test. "All in all, though, the most compelling reports of ivermectin's effects seem to come from the smallest and least controlled samples (all the way down to anecdotal results) while the larger and more well-controlled trials tend to produce equivocal evidence at best," writes Derek Lowe, a medical chemist working in the pharmaceutical industry. "My current opinion is pretty much exactly that of the WHO guidance: I do not think that the current evidence is strong enough to say that ivermectin is a useful therapy for coronavirus patients. I know that there are quite a few studies out there in the literature, but they suffer from various combinations of small sample size, poor trial design, not enough data reported, and (in many cases) inconclusive statistics."

Should people on their deathbeds be allowed to try anything to save themselves? Should the entire world be allowed to practice self-care on a grand scale? These are some of the questions American author, journalist, and podcaster Matt Taibbi poses in an article via Substack. He argues that ivermectin "has become hostage to a larger global fight between populists and anti-populists."

UPDATE (2/18/2021): CNN reports "The antiparasitic drug ivermectin doesn't prevent severe disease from Covid-19 any more effectively than symptom management and close observation by medical professionals, according to a study published Friday in the journal JAMA Internal Medicine." In fact, slightly more patients in the ivermectin group went on to need extra oxygen compared with those who took a placebo, though the difference was not statistically significant.... [T]hey also looked at whether patients needed to be hospitalized, had to go on a ventilator, needed intensive care or died from their infections. There was no meaningful difference in outcomes between the group that took ivermectin and those who got the placebo treatment.

It was a randomized-controlled trial, the gold standard of medical research, in which researchers test an intervention against a placebo....

In addition to the fact that ivermectin didn't work, people who took it had more side effects than those who didn't, and sometimes those side effects were severe, including heart attacks, anemia and diarrhea that led to shock.

A simple blood test that can detect more than 50 types of cancer before any clinical signs or symptoms of the disease emerge in a person is accurate enough to be rolled out as a screening test, according to scientists. The Guardian reports: The test, which is also being piloted by NHS England in the autumn, is aimed at people at higher risk of the disease including patients aged 50 or older. It is able to identify many types of the disease that are difficult to diagnose in the early stages such as head and neck, ovarian, pancreatic, esophageal and some blood cancers. Scientists said their findings, published in the journal Annals of Oncology, show that the test accurately detects cancer often before any signs or symptoms appear, while having a very low false positive rate.

The test, developed by US-based company Grail, looks for chemical changes in fragments of genetic code "cell-free DNA (cfDNA)" that leak from tumors into the bloodstream. The Guardian first reported on the test last year and how it had been developed using a machine learning algorithm a type of artificial intelligence. It works by examining the DNA that is shed by tumors and found circulating in the blood. More specifically, it focuses on chemical changes to this DNA, known as methylation patterns. Now the latest study has revealed the test has an impressively high level of accuracy. Scientists analyzed the performance of the test in 2,823 people with the disease and 1,254 people without. It correctly identified when cancer was present in 51.5% of cases, across all stages of the disease, and wrongly detected cancer in only 0.5% of cases.

In solid tumors that do not have any screening options "such as esophageal, liver and pancreatic cancers" the ability to generate a positive test result was twice as high (65.6%) as that for solid tumors that do have screening options such as breast, bowel, cervical and prostate cancers. Meanwhile, the overall ability to generate a positive test result in cancers of the blood, such as lymphoma and myeloma, was 55.1%. The test correctly also identified the tissue in which the cancer was located in the body in 88.7% of cases.

"With just over half of the U.S. population fully vaccinated against COVID-19, and two-thirds having received one dose, a clear and unambiguous trend has emerged," writes Slashdot reader quonset. "Not only have deaths plunged from approximately 3,400 per day in January to roughly 300 per day now, 98% to 99% of all COVID-19 deaths are now from people who aren't vaccinated." MarketWatch reports: An Associated Press analysis of available government data from May shows that "breakthrough" infections in fully vaccinated people accounted for fewer than 1,200 of more than 853,000 COVID-19 hospitalizations. That's about 0.1%. And only about 150 of the more than 18,000 COVID-19 deaths in May were in fully vaccinated people. That translates to about 0.8%, or five deaths per day on average.

The preventable deaths will continue, experts predict, with unvaccinated pockets of the nation experiencing outbreaks in the fall and winter. Ali Mokdad, a professor of health metrics sciences at the University of Washington in Seattle, said modeling suggests the nation will hit 1,000 deaths per day again next year. In Arkansas, which has one of the lowest vaccination rates in the nation, with only about 33% of the population fully protected, cases, hospitalizations and deaths are rising. "It is sad to see someone go to the hospital or die when it can be prevented," Gov. Asa Hutchinson tweeted as he urged people to get their shots.