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China

US Intel Agencies Are Reviewing Genetic Data From Wuhan Lab (cnn.com) 145

ytene writes: CNN is claiming an exclusive scoop, with an article reporting that U.S. intelligence agencies have scored a massive trove of Covid-19 genetic data, which, CNN suggests, comes from the Wuhan research lab. More than the complex challenge of absorbing and understanding the "mountain" of raw data, U.S. researchers are going to have to translate the material from native Mandarin before the real work can begin. Whilst there has obviously been a lot of interest in a clear identification of the source, it isn't clear how such a revelation could have a material impact on the efficacy of vaccines or the take-up of the treatment. It might, however, give useful clues to help understand where or how the next deadly outbreak could develop. "It's unclear exactly how or when U.S. intelligence agencies gained access to the information, but the machines involved in creating and processing this kind of genetic data from viruses are typically connected to external cloud-based servers -- leaving open the possibility they were hacked," notes CNN, citing multiple people familiar with the matter.

The report also notes that senior intelligence officials are "genuinely split between the two prevailing theories on the pandemic's origins." The World Health Organization says wildlife farms in southern China are the most likely source of the COVID-19 pandemic, but the theory that the virus accidentally escaped from a lab in Wuhan is still being investigated. According to a CNN report last month, "[S]enior Biden administration officials overseeing the 90-day review now believe the theory that the virus accidentally escaped from a lab in Wuhan is at least as credible as the possibility that it emerged naturally in the wild -- a dramatic shift from a year ago, when Democrats publicly downplayed the so-called lab leak theory."
United States

The CDC Needs To Stop Confusing the Public (nytimes.com) 219

Dr. Zeynep Tufekci, an associate professor at the University of North Carolina, writing at The New York Times: The C.D.C. faces three major problems. The first is reality: a sustained campaign of misinformation against vaccines and other public health measures, originating mostly with right-wing commentators and politicians, and a new media environment that has upended traditional information flows.

Second, the C.D.C. is still mired in the fog of pandemic, with too little data, collected too slowly, leaving it chasing epidemic waves and trying to make sense of information from other countries. Epidemics spread exponentially, so delayed responses make problems much worse. If the response to a crisis comes after many people are already aware of it brewing, it leaves them confused and fearful if they look to the C.D.C. for guidance, and vulnerable to misinformation if they do not.

Third, the agency is simply not doing a good job at what the pamphlet advises: being first, right and credible, and avoiding mixed messaging, delays and confusion. It's hard not to have sympathy for its predicament. The previous administration undermined the C.D.C., and anti-vaxxers' deliberate misinformation assault has not made the agency's job any easier. The digital public sphere operates fast and furious, and that's difficult for traditional institutions to keep up with or to counter. All this makes it even more important that the C.D.C. properly handle what's under its control.

The response to the Delta variant has been too slow. Data from other countries made it clear months ago that it posed a great threat. Unfortunately, the United States already doesn't systematically collect the kind of data needed on many important indicators. Making things worse, in early May, the C.D.C. stopped tracking breakthrough infections among the vaccinated unless they were hospitalized or worse, even though the reason for continued surveillance is to see and understand changes in an outbreak as early as possible. June passed with little change in the government's response, despite multiple technical papers from Public Health England showing that the Delta variant was much more transmissible and possibly more severe and that it was able to cause more breakthrough infections among the vaccinated. Detailed contact tracing from Singapore also showed that some of the vaccinated were transmitting.

Science

Historical Language Records Reveal a Surge of Cognitive Distortions in Recent Decades (pnas.org) 103

From a paper on PNAS [PDF]: Can entire societies become more or less depressed over time? Here, we look for the historical traces of cognitive distortions, thinking patterns that are strongly associated with internalizing disorders such as depression and anxiety, in millions of books published over the course of the last two centuries in English, Spanish, and German. We find a pronounced "hockey stick" pattern: Over the past two decades the textual analogs of cognitive distortions surged well above historical levels, including those of World War I and II, after declining or stabilizing for most of the 20th century. Our results point to the possibility that recent socioeconomic changes, new technology, and social media are associated with a surge of cognitive distortions.

Individuals with depression are prone to maladaptive patterns of thinking, known as cognitive distortions, whereby they think about themselves, the world, and the future in overly negative and inaccurate ways. These distortions are associated with marked changes in an individual's mood, behavior, and language. We hypothesize that societies can undergo similar changes in their collective psychology that are reflected in historical records of language use. Here, we investigate the prevalence of textual markers of cognitive distortions in over 14 million books for the past 125 y and observe a surge of their prevalence since the 1980s, to levels exceeding those of the Great Depression and both World Wars. This pattern does not seem to be driven by changes in word meaning, publishing and writing standards, or the Google Books sample. Our results suggest a recent societal shift toward language associated with cognitive distortions and internalizing disorders.

Science

Giraffes Have Been Misunderstood and Are Just as Socially Complex as Elephants, Study Says (cnn.com) 31

An anonymous reader shares a report: With their crane-like necks, spindle legs and knobbly knees, giraffes are among the best loved and most recognizable of animals. Despite their elevated stature, however, giraffes have kept their surprisingly intricate social behavior under wraps. Once perceived as humble creatures that focused solely on feeding their majestic bodies, one book from 1991 described the giraffe as "socially aloof, forming no lasting bonds with its fellows and associating in the most casual way."

But new research from the University of Bristol, published Tuesday in the journal Mammal Review, suggests giraffes have been misunderstood and are in fact a highly complex and social species. The most surprising thing for me is that it has taken until 2021 to recognize that giraffes have a complex social system. We have known for decades about other species of socially complex mammal, such as elephants, primates and cetaceans, but it is baffling to me how such a charismatic and well-known species as the giraffe could have been so understudied until recently," said Zoe Muller, study author and biologist at the University Of Bristol's School of Biological Sciences.

News

Head of UN Health Agency Seeks Vaccine Booster Moratorium (apnews.com) 193

The head of the World Health Organization called Wednesday for a moratorium on administering booster shots of COVID-19 vaccines as a way to help ensure that doses are available in countries where few people have received their first shots. From a report: WHO Director-General Tedros Adhanom Ghebreyesus made the appeal mostly to wealthier countries that have far outpaced the developing world in numbers of vaccinations. He said richer countries have administered about 100 doses of coronavirus vaccines for every 100 people on average, while low-income countries -- hampered by short supplies -- have provided only about 1.5 doses per 100 people.

WHO officials say the science is unproven about whether giving booster shots to people who have already received two vaccine doses is effective in preventing the spread of the coronavirus. The U.N. health agency has repeatedly called for rich countries to do more to help improve access to vaccines in the developing world. It has argued that no one is safe until everyone is safe because the longer and more widely the coronavirus circulates, the greater the chance that new variants could emerge -- and prolong a global crisis in fighting the pandemic.

Science

Retracted COVID Paper Lives on in New Citations (medpagetoday.com) 66

Researchers around the world have continued breathing new life into a retracted study, which suggested that common antihypertensive medications were harmful in patients with COVID-19. From a report: Published online on May 1, 2020 in the New England Journal of Medicine, the study relied on Surgisphere data to claim an association between renin-angiotensin-aldosterone system (RAAS) inhibitor therapy and worse outcomes in hospitalized COVID-19 patients with cardiovascular disease. The journal retracted the paper due to concerns about fraudulent data on June 4, 2020 in a widely publicized move, but the study has continued to rack up citations -- totaling at least 652 as of May 31, 2021, reported Todd Lee, MD, MPH, of McGill University in Montreal, and colleagues.

Just 17.6% of verified citations acknowledged or noted that the paper was retracted, according to their research letter published in JAMA Internal Medicine. In May of this year alone -- 11 months after the article was retracted -- it was referenced 21 times. "Our findings challenge authors, peer reviewers, journal editors, and academic institutions to do a better job of addressing the broader issues of ongoing citations of retracted scientific studies and protecting the integrity of the medical literature," Lee's group urged. The hypothesis that angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) may be harmful in patients with COVID-19 has been floated since the early days of the pandemic, with the reasoning being that since the SARS-CoV-2 virus enters human cells through ACE2 receptors, upregulation of these receptors could put patients at risk.

Math

Australian Mathematician Discovers Applied Geometry Engraved on 3,700-year-old Tablet (theguardian.com) 81

An Australian mathematician has discovered what may be the oldest known example of applied geometry, on a 3,700-year-old Babylonian clay tablet. Known as Si.427, the tablet bears a field plan measuring the boundaries of some land. From a report: The tablet dates from the Old Babylonian period between 1900 and 1600 BCE and was discovered in the late 19th century in what is now Iraq. It had been housed in the Istanbul Archaeological Museum before Dr Daniel Mansfield from the University of New South Wales tracked it down. Mansfield and Norman Wildberger, an associate professor at UNSW, had previously identified another Babylonian tablet as containing the world's oldest and most accurate trigonometric table. At the time, they speculated the tablet was likely to have had some practical use, possibly in surveying or construction. That tablet, Plimpton 322, described right-angle triangles using Pythagorean triples: three whole numbers in which the sum of the squares of the first two equals the square of the third -- for example, 3^2 + 4^2 = 5^2.
Earth

'Totally New' Idea Suggests Longer Days On Early Earth Set Stage For Complex Life (sciencemag.org) 27

"A research team has proposed a novel link between how fast our planet spun on its axis, which defines the length of a day, and the ancient production of additional oxygen," reports Science Magazine. "Their modeling of Earth's early days, which incorporates evidence from microbial mats coating the bottom of a shallow, sunlit sinkhole in Lake Huron, produced a surprising conclusion: as Earth's spin slowed, the resulting longer days could have triggered more photosynthesis from similar mats, allowing oxygen to build up in ancient seas and diffuse up into the atmosphere." From the report: As a postdoc at the University of Michigan, Ann Arbor, Klatt had studied microbial mats growing on sediments in the Middle Island Sinkhole in Lake Huron. There, the water is shallow enough for the cyanobacteria to get enough sunlight for photosynthesis. Oxygen-depleted water and sulfur gas bubble up from the lake floor, creating anoxic conditions that roughly approximate conditions of early Earth. Scuba divers collected samples of the microbial mats and in the lab, Klatt tracked the amount of oxygen they released under various day lengths simulated with halogen lamps. The longer the exposure to light, the more of the gas the mats released.

Excited, Klatt and Arjun Chennu, a modeler from the Leibniz Center for Tropical Marine Research, set up a numerical model to calculate how much oxygen ancient cyanobacteria could have produced on a global scale. When the microbial mat results and other data were plugged into this computer program, it revealed a key interaction between light exposure and the microbial mats. Typically, microbial mats "breathe" in almost as much oxygen at night as they produce during the day. But as Earth's spin slowed, the additional continuous hours of daylight allowed the simulated mats to build up a surplus, releasing oxygen into the water. As a result, atmospheric oxygen tracked estimated day length over the eons: Both rose in a stepped fashion with a long plateau.

This "elegant" idea helps explain why oxygen didn't build up in the atmosphere as soon as cyanobacteria appeared on the scene 3.5 billion years ago, says Timothy Lyons, a biogeochemist at the University of California, Riverside. Because day length was still so short back then, oxygen in the mats never had a chance to build up enough to diffuse out. "Long daytimes simply allow more oxygen to escape to the overlying waters and eventually the atmosphere," Lyons says. Still, Lyons and others say, many factors likely contributed to the rise in oxygen. For example, Fischer suspects free-floating cyanobacteria, not just those in rock-affixed mats, were big players. Benjamin Mills, an Earth system modeler at the University of Leeds, thinks the release of oxygen-binding minerals by ancient volcanoes likely countered the early buildup of the gas at times and should be factored into oxygen calculations. Nonetheless, changing day length "is something that should be considered in more detail," he says. "I'll try to add it to our Earth system models."

Medicine

NYC Will Require Vaccines For Entry To Restaurants and Gyms; Requirement Can Be Met With An App (theverge.com) 492

Mayor Bill de Blasio announced today that New York City will become the first major U.S. city to require proof of vaccination to enter all restaurants, fitness centers and indoor entertainment venues. "If you're unvaccinated, unfortunately, you will not be able to participate in many things," de Blasio said. "If you want to participate in our society fully, you've got to get vaccinated." As The Verge reports, "New Yorkers can meet those requirements by carrying their vaccination card or scanning and storing it in one of two authorized mobile apps." From the report: The spread of the highly contagious Delta variant is being cited as a reason to increase restrictions without returning to a full lockdown or other measures. The program is scheduled to launch on August 13th, with enforcement slated to start on September 13th. It doesn't introduce any new documentation; the name is a reference to it serving as a "key" to the city's recovery.

Workers and patrons can confirm their vaccination status (at least one dose administered) in one of three ways: Vaccination card; NYC COVID Safe exposure notification app (iOS, Android); or NYS Excelsior Pass app.

ISS

Boeing Scrubs Launch of Starliner Crew Capsule To Space Station (cbsnews.com) 60

The launch of Boeing's Starliner crew capsule on an unpiloted test flight to the International Space Station was scrubbed Tuesday because of an undisclosed technical issue. Mission managers told the launch team to recycle for another attempt Wednesday at 12:57 p.m. ET, weather permitting. From a report: The launching atop a United Launch Alliance Atlas 5 rocket initially was planned for last Friday, but NASA ordered a delay while Russian space station engineers resolved problems with a newly arrived laboratory module. Over the weekend, the Starliner launch was reset for Tuesday. Forecasters monitoring Florida's typically stormy summer afternoon weather predicted a 60% chance of acceptable conditions then lowered the odds to 50-50. The team pressed ahead with fueling, but around 10:30 a.m., Boeing confirmed a scrub, tweeting, "We're confirming today's #Starliner Orbital Flight Test-2 launch is scrubbed. More details soon."

The Starliner flight marks a major milestone for Boeing and NASA as the agency transitions from hitching rides aboard Russian Soyuz spacecraft to fielding commercial crew ships built by Boeing and SpaceX. SpaceX, under a $2.6 billion NASA contract, launched its Crew Dragon spacecraft on a successful unpiloted test flight in 2019 and a piloted test flight last year. Since then, the California rocket builder has launched two operational flights to the space station carrying two long-duration crews to the outpost.

Medicine

A Magnetic Helmet Shrunk a Deadly Tumor In World-First Test (engadget.com) 157

An anonymous reader quotes a report from Engadget: As part of the latest neurological breakthrough, researchers used a helmet that generates a magnetic field to shrink a deadly tumor by a third. The 53-year-old patient who underwent the treatment ultimately passed away due to an unrelated injury. But, an autopsy of his brain showed that the procedure had removed 31 percent of the tumor mass in a short time. The test marked the first noninvasive therapy for a deadly form of brain cancer known as glioblastoma.

The helmet features three rotating magnets connected to a microprocessor-based electronic controller operated by a rechargeable battery. As part of the therapy, the patient wore the device for five weeks at a clinic and then at home with the help of his wife. The resulting magnetic field therapy created by the helmet was administered for two hours initially and then ramped up to a maximum of six hours per day. During the period, the patient's tumor mass and volume shrunk by nearly a third, with shrinkage appearing to correlate with the treatment dose. The inventors of the device -- which received FDA approval for compassionate use treatment -- claim it could one day help treat brain cancer without radiation or chemotherapy.
"Our results... open a new world of non-invasive and nontoxic therapy...with many exciting possibilities for the future," said David S. Baskin, corresponding author and director of the Kenneth R. Peak Center for Brain and Pituitary Tumor Treatment in the Department of Neurosurgery at Houston Methodist Neurological Institute. Details of the procedure have been published in the peer-reviewed journal Frontiers in Oncology.
Science

A Plant That 'Cannot Die' Reveals Its Genetic Secrets (nytimes.com) 58

Events in the genome of Welwitschia have given it the ability to survive in an unforgiving desert for thousands of years. From a report: The longest-lived leaves in the plant kingdom can be found only in the harsh, hyperarid desert that crosses the boundary between southern Angola and northern Namibia. A desert is not, of course, the most hospitable place for living things to grow anything, let alone leafy greens, but the Namib Desert -- the world's oldest with parts receiving less than two inches of precipitation a year -- is where Welwitschia calls home. In Afrikaans, the plant is named "tweeblaarkanniedood," which means "two leaves that cannot die." The naming is apt: Welwitschia grows only two leaves -- and continuously -- in a lifetime that can last millenniums. "Most plants develop a leaf, and that's it," said Andrew Leitch, a plant geneticist at Queen Mary University of London. "This plant can live thousands of years, and it never stops growing. When it does stop growing, it's dead."

Some of the largest plants are believed to be over 3,000 years old, with two leaves steadily growing since the beginning of the Iron Age, when the Phoenician alphabet was invented and David was crowned King of Israel. By some accounts, Welwitschia is not much to look at. Its two fibrous leaves, buffeted by dry desert winds and fed on by thirsty animals, become shredded and curled over time, giving Welwitschia a distinctly octopus-like look. One 19th-century director of Kew Gardens in London remarked, "it is out of the question the most wonderful plant ever brought to this country and one of the ugliest."

But since it was first discovered, Welwitschia has captivated biologists including Charles Darwin and the botanist Friedrich Welwitsch after whom the plant is named: It is said that when Welwitsch first came across the plant in 1859, "he could do nothing but kneel down on the burning soil and gaze at it, half in fear lest a touch should prove it a figment of the imagination." In a study published last month in Nature Communications, researchers report some of the genetic secrets behind Welwitschia's unique shape, extreme longevity and profound resilience.

Social Networks

To Fight Vaccine Misinformation, US Recruits an 'Influencer Army' (nytimes.com) 314

The New York Times tells the story of 17-year-old Ellie Zeiler, a TikTok creator with over 10 million followers, who received an email in June from Village Marketing, an influencer marketing agency.

"It said it was reaching out on behalf of another party: the White House." Would Ms. Zeiler, a high school senior who usually posts short fashion and lifestyle videos, be willing, the agency wondered, to participate in a White House-backed campaign encouraging her audience to get vaccinated against the coronavirus...? Ms. Zeiler quickly agreed, joining a broad, personality-driven campaign to confront an increasingly urgent challenge in the fight against the pandemic: vaccinating the youthful masses, who have the lowest inoculation rates of any eligible age group in the United States...

To reach these young people, the White House has enlisted an eclectic army of more than 50 Twitch streamers, YouTubers, TikTokers and the 18-year-old pop star Olivia Rodrigo, all of them with enormous online audiences. State and local governments have begun similar campaigns, in some cases paying "local micro influencers" — those with 5,000 to 100,000 followers — up to $1,000 a month to promote Covid-19 vaccines to their fans. The efforts are in part a counterattack against a rising tide of vaccine misinformation that has flooded the internet, where anti-vaccine activists can be so vociferous that some young creators say they have chosen to remain silent on vaccines to avoid a politicized backlash...

State and local governments have taken the same approach, though on a smaller scale and sometimes with financial incentives. In February, Colorado awarded a contract worth up to $16.4 million to the Denver-based Idea Marketing, which includes a program to pay creators in the state $400 to $1,000 a month to promote the vaccines... Posts by creators in the campaign carry a disclosure that reads "paid partnership with Colorado Dept. of Public Health and Environment...." Other places, including New Jersey, Oklahoma City County and Guildford County, N.C., as well as cities like San Jose, Calif., have worked with the digital marketing agency XOMAD, which identifies local influencers who can help broadcast public health information about the vaccines.

In another article, the Times notes that articles blaming Bill Gates for the pandemic appeared on two local news sites (one in Atlanta, and one in Phoenix) that "along with dozens of radio and television stations, and podcasts aimed at local audiences...have also become powerful conduits for anti-vaccine messaging, researchers said."
AI

Hundreds of AI Tools Were Built to Catch Covid. None of Them Helped (technologyreview.com) 108

At the start of the pandemic, remembers MIT Technology Review's senior editor for AI, the community "rushed to develop software that many believed would allow hospitals to diagnose or triage patients faster, bringing much-needed support to the front lines — in theory.

"In the end, many hundreds of predictive tools were developed. None of them made a real difference, and some were potentially harmful." That's the damning conclusion of multiple studies published in the last few months. In June, the Turing Institute, the UK's national center for data science and AI, put out a report summing up discussions at a series of workshops it held in late 2020. The clear consensus was that AI tools had made little, if any, impact in the fight against covid.

This echoes the results of two major studies that assessed hundreds of predictive tools developed last year. Laure Wynants, an epidemiologist at Maastricht University in the Netherlands who studies predictive tools, is lead author of one of them, a review in the British Medical Journal that is still being updated as new tools are released and existing ones tested. She and her colleagues have looked at 232 algorithms for diagnosing patients or predicting how sick those with the disease might get. They found that none of them were fit for clinical use. Just two have been singled out as being promising enough for future testing. "It's shocking," says Wynants. "I went into it with some worries, but this exceeded my fears."

Wynants's study is backed up by another large review carried out by Derek Driggs, a machine-learning researcher at the University of Cambridge, and his colleagues, and published in Nature Machine Intelligence. This team zoomed in on deep-learning models for diagnosing covid and predicting patient risk from medical images, such as chest x-rays and chest computer tomography (CT) scans. They looked at 415 published tools and, like Wynants and her colleagues, concluded that none were fit for clinical use. "This pandemic was a big test for AI and medicine," says Driggs, who is himself working on a machine-learning tool to help doctors during the pandemic. "It would have gone a long way to getting the public on our side," he says. "But I don't think we passed that test...."

If there's an upside, it is that the pandemic has made it clear to many researchers that the way AI tools are built needs to change. "The pandemic has put problems in the spotlight that we've been dragging along for some time," says Wynants.

The article suggests researchers collaborate on creating high-quality (and shared) data sets — possibly by creating a common data standard — and also disclose their ultimate models and training protocols for review and extension. "In a sense, this is an old problem with research. Academic researchers have few career incentives to share work or validate existing results.

"To address this issue, the World Health Organization is considering an emergency data-sharing contract that would kick in during international health crises."
Space

2 Red Objects Found In the Asteroid Belt. They Shouldn't Be There. (nytimes.com) 80

Slashdot reader fahrbot-bot quotes the New York Times: Two red things are hiding in a part of the solar system where they shouldn't be. The space rocks may have come from beyond Neptune, and potentially offer hints at the chaos of the early solar system.

Scientists led by Sunao Hasegawa from JAXA, the Japanese space agency, reported in The Astrophysical Journal Letters on July 26, 2021 that two objects, called 203 Pompeja and 269 Justitia, spotted in the asteroid belt between Mars and Jupiter appear to have originated beyond Neptune. The discoveries could one day provide direct evidence of the chaos that existed in the early solar system.

"If true it would be a huge deal," says Hal Levison, a planetary scientist at the Southwest Research Institute in Colorado, who was not involved in the research...

"People have been talking about some fraction of asteroids coming from the Kuiper belt for quite a while now," said Josh Emery, a planetary scientist from Northern Arizona University who was not involved in the paper. He said the research "definitely takes a step" toward finding evidence to support that hypothesis. Not everyone is convinced just yet. Dr. Levison, who was also not involved in the paper, says objects should become less red as they approach the sun. "It seems to be inconsistent with our models," said Dr. Levison, who is the head of NASA's Lucy mission, which is scheduled to launch in October to study Jupiter's Trojans [asteroids captured in its orbit].

Michaël Marsset from the Massachusetts Institute of Technology, a co-author on the paper, agrees that it's not clear why they would be so red, but it is possibly related to how long it took them to become implanted into the asteroid belt. Some Trojans may also be as red, but haven't been found yet.

To truly confirm the origin of 203 Pompeja and 269 Justitia, a spacecraft would likely need to visit them.

Youtube

YouTube Bans Sky News Australia for One Week Over Misinformation (bbc.co.uk) 288

"YouTube has barred Sky News Australia from uploading new content for a week, saying it had breached rules on spreading Covid-19 misinformation," writes the BBC.

Long-time Slashdot reader Hope Thelps shares their report: YouTube issued a "strike" under its three-strike policy, the last of which means permanent removal. It did not point to specific items but said it opposed material that "could cause real-world harm".

The TV channel's digital editor said the decision was a disturbing attack on the ability to think freely. Sky News Australia is owned by a subsidiary of Rupert Murdoch's News Corp and has 1.85 million YouTube subscribers. The ban could affect its revenue stream from Google.

A YouTube statement said it had "clear and established Covid-19 medical misinformation policies based on local and global health authority guidance". A spokesperson told the Guardian it "did not allow content that denies the existence of Covid-19" or which encouraged people "to use hydroxychloroquine or ivermectin to treat or prevent the virus". Neither has been proven to be effective against Covid.

United Kingdom

UK Pharmaceutical Firm Fined For Hiking Drug Price 6,000% (theguardian.com) 182

Slashdot reader Bruce66423 shares a report from the Guardian: The UK's competition watchdog has imposed fines of more than £100m on the pharmaceutical company Advanz and its former private equity owners after it was found to have inflated the price of its thyroid tablets by up to 6,000%. An investigation by the Competition and Markets Authority (CMA) found that the private-equity backed pharmaceutical company charged "excessive and unfair prices" for liothyronine tablets, which are used to treat thyroid hormone deficiency.

Advanz took advantage of limited competition in the market from 2007 to bring in sustained price hikes for the drug, often used by patients with depression and fatigue, of more than 6,000% in the space of 10 years, according to the investigation. The CMA said that between 2007 and 2017, the price paid by the National Health Service for liothyronine tablets rose from £4.46 to £258.19, a rise of almost 6,000%, while production costs remained broadly stable... Dr Andrea Coscelli, the CMA's chief executive, said: "Advanz's decision to ratchet up the price of liothyronine tablets and impose excessive and unfair prices for over eight years came at a huge cost to the NHS, and ultimately to UK taxpayers.

"But that wasn't all. It also meant that people dealing with depression and extreme fatigue, as a result of their thyroid conditions, were told they could not continue to receive the most effective treatment for them due its increased price."

Science

Nobel Winner Steven Weinberg, Who Unified Two of Physics' Fundamental Forces, Has Died (livescience.com) 17

Long-time Slashdot reader Mogster quotes : Steven Weinberg, a Nobel-prize winning physicist whose work helped link two of the four fundamental forces, has died at the age of 88, the University of Texas at Austin (UT Austin) announced Saturday (July 24).

HIs work was foundational to the Standard Model, the overarching physics theory that describes how subatomic particles behave. His seminal work was a slim, three-page paper published in 1967 in the journal Physical Review Letters and entitled "A Model of Leptons." In it, he predicted how subatomic particles known as W, Z and the famous Higgs boson should behave — years before those particles were detected experimentally, according to a statement from UT Austin.

The paper also helped unify the electromagnetic force and the weak force and predicted that so-called "neutral weak currents" governed how particles would interact, according to the statement. In 1979, Weinberg and physicists Sheldon Glashow and Abdus Salam earned the Nobel Prize in physics for this work. Throughout his life, Weinberg would continue his search for a unified theory that would unite all four forces, according to the statement.

Weinberg also wrote a book called "The First Three Minutes: A Modern View of the Origin of the Universe" — in 1977.
Space

Rocket Lab Successfully Carries a US Military Satellite Into Orbit (spaceflightnow.com) 20

"Resuming launches after a mission failure two months ago, Rocket Lab successfully placed a small U.S. military research and development satellite into orbit Thursday following a fiery liftoff from New Zealand..." reports Spaceflight Now: Heading east from Mahia, the rocket's first stage burned its nine engines for about two-and-a-half minutes, followed by a six-minute firing of the second stage engine to reach a preliminary parking orbit. A kick stage deployed from the the Electron rocket's second stage...

Rocket Lab, a California-based company founded in New Zealand, confirmed a good deployment of the U.S. military's small experimental Monolith spacecraft about 52 minutes after liftoff. "Payload deployed, flawless launch and mission by the team!" tweeted Peter Beck, Rocket Lab's founder and CEO.

The mission was the 21st flight of a Rocket Lab Electron launch vehicle since 2017, and the eighth to carry a payload for a U.S. military or intelligence agency customer. It was also the first Rocket Lab mission since May 15, when an Electron rocket failed before reaching orbit with two commercial BlackSky Earth-imaging satellites... The May 15 mission was the third time an Electron rocket failed to reach orbit on 20 attempts since 2017.

China

Early Virus Sequences 'Mysteriously' Deleted Have Been Not-So-Mysteriously Undeleted (nytimes.com) 128

"A batch of early coronavirus data that went missing for a year has emerged from hiding," reports the New York Times. (Jesse Bloom, a virologist at the Fred Hutchinson Cancer Center in Seattle, had found copies of 13 of the deleted sequences on Google Cloud.)

Though their deletion raised some suspicions, "An odd explanation has emerged, stemming from an editorial oversight by a scientific journal," reports the Times. "And the sequences have been uploaded into a different database, overseen by the Chinese government."

The Times also notes that the researchers had already posted their early findings online in March 2020: That month, they also uploaded the sequences to an online database called the Sequence Read Archive, which is maintained by the National Institutes of Health, and submitted a paper describing their results to a scientific journal called Small. The paper was published in June 2020... [A] spokeswoman for the N.I.H. said that the authors of the study had requested in June 2020 that the sequences be withdrawn from the database. The authors informed the agency that the sequences were being updated and would be added to a different database... On July 5, more than a year after the researchers withdrew the sequences from the Sequence Read Archive and two weeks after Dr. Bloom's report was published online, the sequences were quietly uploaded to a database maintained by China National Center for Bioinformation by Ben Hu, a researcher at Wuhan University and a co-author of the Small paper.

On July 21, the disappearance of the sequences was brought up during a news conference in Beijing... According to a translation of the news conference by a journalist at the state-controlled Xinhua News Agency, the vice minister of China's National Health Commission, Dr. Zeng Yixin, said that the trouble arose when editors at Small deleted a paragraph in which the scientists described the sequences in the Sequence Read Archive. "Therefore, the researchers thought it was no longer necessary to store the data in the N.C.B.I. database," Dr. Zeng said, referring to the Sequence Read Archive, which is run by the N.I.H.

An editor at Small, which specializes in science at the micro and nano scale and is based in Germany, confirmed his account. "The data availability statement was mistakenly deleted," the editor, Plamena Dogandzhiyski, wrote in an email. "We will issue a correction very shortly, which will clarify the error and include a link to the depository where the data is now hosted." The journal posted a formal correction to that effect on Thursday.

While the researchers' first report had described their sequences as coming from patients "early in the epidemic," thus provoking intense curiosity, the sequences were, as promised, updated, to include a more specific date after they were published in the database, according to the Times. "They were taken from Renmin Hospital of Wuhan University on January 30 — almost two months after the earliest reports of Covid-19 in China."

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