Rodrigo Perez Ortega writes via Science Magazine: With climate change, heat waves and cold fronts are worsening and taking lives worldwide: about 5 million in the past 20 years, according to at least one study. In a new study published today in Nature Medicine, an international team of researchers estimates that almost 900,000 deaths in the years between 2002 and 2015 could be attributable to extreme temperatures alone in major Latin American cities. This is the most detailed estimate in Latin America, and the first ever for some cities.

To estimate how many people died from intense heat or cold, researchers with the Urban Health in Latin America project -- which studies how urban environments and policies impact the health of city residents in Latin America -- looked at mortality data between 2002 and 2015 from registries of 326 cities with more than 100,000 residents, in nine countries throughout Latin America. They calculated the average daily temperatures and estimated the temperature range for each city from a public data set of atmospheric conditions. If a death occurred either on the 18 hottest or the 18 coldest days that each city experienced in a typical year, they linked it to extreme temperatures. Using a statistical model, the researchers compared the risk of dying on very hot and cold days, and this risk with the risk of dying on temperate days. They found that in Latin American metropolises, nearly 6% -- almost 1 million -- of all deaths between those years happened on days of extreme heat and cold. They also created an interactive map with the data for individual cities.

When the team analyzed the specific cause of these deaths in the registries, they found -- consistent with previous studies -- that extreme temperatures are often linked to deaths from cardiovascular and respiratory diseases. Extreme heat makes the heart pump more blood and causes dehydration and pulmonary stress. Extreme cold, on the other hand, can make the heart pump less blood and cause hypotension and, in some cases, organ failure. The team also found older adults are especially vulnerable to extreme temperatures, with 7.5% of deaths among them correlated to extreme heat and cold during the study period. Although the numbers varied from year to year, in 2015, for instance, more than 16,000 deaths -- out of nearly 855,000 -- among people ages 65 or older were attributable to extreme temperatures. Latin America's aging population is projected to rise more quickly than other parts of the world -- from 9% in 2020 to 19% in 2050, by some estimates (PDF). [...] Although deaths on extremely cold days -- about 785,000 -- were much higher than those on extremely hot days -- about 103,000 -- overall there were more days with intense cold, which could explain this difference. But for some cities, such as Buenos Aires, Rio de Janeiro, and Merida, heat is more deadly than cold: The researchers estimated that on very hot days, the chance of dying increases by 5.7% for every 1C increase in temperature.

Disinformation operatives seek to undermine firms in the Western world as China fights to maintain near-monopoly power. From a report: An online influence campaign carried out by a group that promotes China's political interests is targeting Western companies that mine and process rare-earth elements, according to a new report from cybersecurity firm Mandiant. The campaign, which is playing out in Facebook groups and micro-targeted tweets, is trying to stoke environmentalist protests against the companies in the US. The operation is attributed to an online group code-named Dragonbridge, which has also been responsible for campaigns claiming that covid-19 originated in the United States. Its latest campaign has increased in intensity in recent weeks as part of a strategic battle between China and its Western adversaries over who controls the precious resources and their own destiny.

"We are headed to a future where the likelihood of tools like influence operations being used against key industries will only increase," says John Hultquist, Mandiant's head of intelligence. "As competition between the US and China changes, the nature of the competition may become more aggressive." It's also proof that influence campaigns are not easy: Dragonbridge has largely failed in its bid to draw negative attention to the Western companies. Shane Huntley, who directs Google's Threat Analysis Group and has tracked Dragonbridge since 2019, previously tweeted that his team has taken an "aggressive" approach against the influence operation but that "it really is amazing for all the effort put in how LITTLE engagement these channels get from real viewers."

Martian rock samples collected by NASA's Curiosity Mars rover show signs of key ingredients for life as we know it on Earth. Space.com reports: The venerable Curiosity Rover drilled samples from Gale crater, the site of an ancient lake on Mars. Using these samples, scientists were able, for the first time, to measure the total amount of organic carbon in Martian rocks, according to a statement from NASA. Organic carbon, which is carbon bound to a hydrogen atom, is a prerequisite for organic molecules created and used by all known forms of life. However, organic carbon can also come from non-living sources, such as meteorites and volcanic eruptions. While previous studies have detected organic carbon in smaller quantities in Martian rock samples, the new measurements provide insight into the total amount of carbon in organic compounds.

"Total organic carbon is one of several measurements [or indices] that help us understand how much material is available as feedstock for prebiotic chemistry and potentially biology," Jennifer Stern, lead author of the study and a space scientist at NASA's Goddard Space Flight Center in Greenbelt, Maryland, said in the statement. "We found at least 200 to 273 parts per million of organic carbon. This is comparable to or even more than the amount found in rocks in very low-life places on Earth, such as parts of the Atacama Desert in South America, and more than has been detected in Mars meteorites."

[...] However, in addition to organic carbon, the researchers identified other signs suggesting Gale crater may have once supported life, including the presence of chemical energy sources, and chemical compounds such as oxygen, nitrogen and sulfur and low acidity. "Basically, this location would have offered a habitable environment for life, if it ever was present," Stern said in the statement. Their findings were published in the Proceedings of the National Academy of Sciences.

An anonymous reader quotes a report from SciTechDaily: An exceptional organism with an extremely complex brain and cognitive abilities makes the octopus very unique among invertebrates. So much so that it resembles vertebrates more than invertebrates in several aspects. The neural and cognitive complexity of these animals could originate from a molecular analogy with the human brain, as discovered by a research paper that was recently published in BMC Biology and coordinated by Remo Sanges from Scuola Internazionale Superiore di Studi Avanzati (SISSA) of Trieste and by Graziano Fiorito from Stazione Zoologica Anton Dohrn of Naples. This research shows that the same 'jumping genes' are active both in the human brain and in the brain of two species, Octopus vulgaris, the common octopus, and Octopus bimaculoides, the Californian octopus. A discovery that could help us understand the secret of the intelligence of these remarkable organisms.

Sequencing the human genome revealed as early as 2001 that over 45% of it is composed of sequences called transposons, so-called 'jumping genes' that, through molecular copy-and-paste or cut-and-paste mechanisms, can 'move' from one point to another of an individual's genome, shuffling or duplicating. In most cases, these mobile elements remain silent: they have no visible effects and have lost their ability to move. Some are inactive because they have, over generations, accumulated mutations; others are intact, but blocked by cellular defense mechanisms. From an evolutionary point of view even these fragments and broken copies of transposons can still be useful, as 'raw matter' that evolution can sculpt.

Among these mobile elements, the most relevant are those belonging to the so-called LINE (Long Interspersed Nuclear Elements) family, found in a hundred copies in the human genome and still potentially active. It has been traditionally though that LINEs' activity was just a vestige of the past, a remnant of the evolutionary processes that involved these mobile elements, but in recent years new evidence emerged showing that their activity is finely regulated in the brain. There are many scientists who believe that LINE transposons are associated with cognitive abilities such as learning and memory: they are particularly active in the hippocampus, the most important structure of our brain for the neural control of learning processes. The octopus' genome, like ours, is rich in 'jumping genes', most of which are inactive. Focusing on the transposons still capable of copy-and-paste, the researchers identified an element of the LINE family in parts of the brain crucial for the cognitive abilities of these animals. The discovery, the result of the collaboration between Scuola Internazionale Superiore di Studi Avanzati, Stazione Zoologica Anton Dohrn and Istituto Italiano di Tecnologia, was made possible thanks to next-generation sequencing techniques, which were used to analyze the molecular composition of the genes active in the nervous system of the octopus.

Comparing genomes of intestinal bacteria in various primates and human populations begins to pinpoint the possibly helpful microbes that have gone missing from our guts. From a report: Deep in the human gut, myriad "good" bacteria and other microbes help us digest our food, as well as keep us healthy by affecting our immune, metabolic, and nervous systems. Some of these humble microbial assistants have been in our guts since before humans became human -- certain gut microbes are found in almost all primates, suggesting they first colonized a common ancestor. But humans have also lost many of these helpers found in other primates and may be losing even more as people around the world continue to flock to cities, a researcher reported last week at a microbiology meeting in Washington, D.C. Those absent gut microbes could affect human health, he says.

"This work helps us develop a new understanding of the course of human biological and cultural development," says Lev Tsypin, a microbiology graduate student at the California Institute of Technology who was not involved in the new study. The microbiome comprises all the bacteria, fungi, viruses, and other microscopic life that inhabit an individual, be it a person, a plant, or a planaria. For humans and many other species, the best characterized microbiome centers on the bacteria in the gut. The more microbiologists study these gut microbes, the more they link the bacteria to functions of their hosts. In humans, for example, gut bacteria influence how the immune system responds to pathogens and allergens, or interact with the brain, affecting mood.

Andrew Moeller, an evolutionary biologist at Cornell University, was one of the first to show that gut bacteria and humans have built these relationships over a very long time. Six years ago, he and colleagues reported the work showing human gut microbes are very similar to those in other primates, suggesting their intestinal presence predates the evolution of humans. But his follow-up studies, and work by others, also indicate the human gut microbiome has, in a general sense, become less diverse than the gut microbes in our current primate cousins. One study found 85 microbial genera, such as Bacteroides and Bifidobacterium, in the guts of wild apes, but just 55 in people in U.S. cities. Splitting the difference, people in less developed parts of the world have between 60 and 65 of those bacterial groups, an observation that ties the decrease in microbial diversity to urbanization.

A small NASA-financed spacecraft launched from New Zealand on Tuesday, kicking off the space agency's plans to send astronauts back to the moon in a few years. From a report: The spacecraft, called CAPSTONE, is about the size of a microwave oven. It will study a specific orbit where NASA plans to build a small space station for astronauts to stop at before and after going to the moon's surface. At 9:55 p.m. local time (5:55 a.m. Eastern time), a 59-foot-tall rocket carrying CAPSTONE lifted off from a launchpad along the eastern coast of New Zealand. Although the mission is gathering information for NASA, it is owned and operated by a private company, Advanced Space, based in Westminster, Colo.

For a spacecraft headed to the moon, CAPSTONE is inexpensive, costing just under $30 million including the launch by Rocket Lab, a U.S.-New Zealand company. The first two stages of Electron rocket placed CAPSTONE into an elliptical orbit around Earth. For this mission, Rocket Lab essentially added a third stage that will methodically raise the altitude of the spacecraft over the next six days. At that point, CAPSTONE will head on its way to the moon, taking a slow but efficient path, arriving on Nov. 13.

Serhat Gumrukcu faces trial in a purported plot to kill an associate who could have exposed him and derailed a drug-development deal worth millions. From a report: Even as a teenager back in Turkey, Serhat Gumrukcu dazzled audiences. In a 2002 video, he opened one of his magic shows dancing with a cane that appeared to be levitating. He was introduced as a medical student and went by the stage name "Dr. No." A little more than a decade later, not long after Mr. Gumrukcu arrived in the U.S., he had his hand in multimillion-dollar oil and real-estate deals. Yet his best-known venture was in medicine. For a time, he thrilled investors with ideas for groundbreaking treatments and drew special notice from the government's top infectious-disease official, Anthony Fauci. In America, the magician had found a new, more lucrative audience.

Enochian Biosciences co-founded by Mr. Gumrukcu in 2018, paid more than $21 million to companies controlled by Mr. Gumrukcu and his husband for consulting, research and the licensing of potential drugs to treat influenza, hepatitis B, HIV and Covid-19, company financial filings show. "Dr. Gumrukcu is one of those rare geniuses that is not bound by scientific discipline or dogma. He sees connections and opportunities often missed," Enochian Vice Chairman Mark Dybul, now chief executive, said in a 2019 news release about Enochian's licensing of a hepatitis B drug from a company controlled by Mr. Gumrukcu. Mr. Gumrukcu's success as a biotech entrepreneur afforded the purchase last year of an $18.4 million office complex in North Hollywood, a neighborhood in Los Angeles, and, earlier, a $5.5 million house in the Hollywood Hills.

Yet much of what people saw in Mr. Gumrukcu was an illusion he cast, misrepresenting himself and his credentials, according to state and federal authorities, court records, former colleagues and those who have sued and won judgments against him over fraudulent medical and financial dealings. Prosecutors now allege that Mr. Gumrukcu arranged the murder of a business associate, Gregory Davis, who threatened to expose him as a fraud. Such a revelation would have put at risk the 39-year-old entrepreneur's deal with Enochian, they said. Mr. Gumrukcu has been in custody at the Metropolitan Detention Center in Los Angeles since his arrest on May 24. A federal grand jury indicted him on murder conspiracy charges, an offense punishable by death.

An anonymous reader quotes a report from Engadget: Johns Hopkins University-led researchers have developed a new technique that let a partially paralyzed man feed himself using robotic arms connected through a brain-machine interface. He only had to make small movements with his fists at certain prompts (such as "select cut location") to have the fork- and knife-equipped arms cut food and bring it to his mouth. He could have dessert within 90 seconds, according to the researchers. The new method centers on a shared control system that minimizes the amount of mental input required to complete a task. He could map his four-degree freedom of movement (two for each hand) to as many as 12 degrees of freedom for controlling the robot arms. The limbs' prompt-based intelligent responses also reduced the workload. The researchers "want to add touch-like sensor feedback instead of relying exclusively on visuals," the report says. "They also hope to improve the accuracy and efficiency while reducing the need for visual confirmation."

nickwinlund77 shares a report from Phys.Org: A new study led by University of Arizona researchers may have solved two mysteries that have long puzzled paleo-climate experts: Where did the ice sheets that rang in the last ice age more than 100,000 years ago come from, and how could they grow so quickly? Understanding what drives Earth's glacial -- interglacial cycles -- the periodic advance and retreat of ice sheets in the Northern Hemisphere -- is no easy feat, and researchers have devoted substantial effort to explaining the expansion and shrinking of large ice masses over thousands of years. The new study, published in the journal Nature Geoscience, proposes an explanation for the rapid expansion of the ice sheets that covered much of the Northern Hemisphere during the most recent ice age, and the findings could also apply to other glacial periods throughout Earth's history.

About 100,000 years ago, when mammoths roamed the Earth, the Northern Hemisphere climate plummeted into a deep freeze that allowed massive ice sheets to form. Over a period of about 10,000 years, local mountain glaciers grew and formed large ice sheets covering much of today's Canada, Siberia and northern Europe. While it has been widely accepted that periodic "wobbling" in the Earth's orbit around the sun triggered cooling in the Northern Hemisphere summer that caused the onset of widespread glaciation, scientists have struggled to explain the extensive ice sheets covering much of Scandinavia and northern Europe, where temperatures are much more mild. [...] "Using both climate model simulations and marine sediment analysis, we show that ice forming in northern Canada can obstruct ocean gateways and divert water transport from the Arctic into the North Atlantic," [said Lofverstrom, an assistant professor of geosciences and head of the UArizona Earth System Dynamics Lab], "and that in turn leads to a weakened ocean circulation and cold conditions off the coast of Scandinavia, which is sufficient to start growing ice in that region."

"These findings are supported by marine sediment records from the North Atlantic, which show evidence of glaciers in northern Canada several thousand years before the European side," said Diane Thompson, assistant professor in the UArizona Department of Geosciences. "The sediment records also show compelling evidence of a weakened deep ocean circulation before the glaciers form in Scandinavia, similar to our modeling results." Together, the experiments suggest that the formation of marine ice in northern Canada may be a necessary precursor to glaciation in Scandinavia, the authors write. [...] "It is possible that the mechanisms we identified here apply to every glacial period, not just the most recent one," [Lofverstrom] said. "It may even help explain more short-lived cold periods such as the Younger Dryas cold reversal (12,900 to 11,700 years ago) that punctuated the general warming at the end of the last ice age."

Dangerous viruses can remain infectious for up to three days in fresh water by hitchhiking on plastic, researchers have found. From a report: Enteric viruses that cause diarrhoea and stomach upsets, such as rotavirus, were found to survive in water by attaching to microplastics, tiny particles less than 5mm long. They remain infectious, University of Stirling researchers found, posing a potential health risk. Prof Richard Quilliam, lead researcher on the project at Stirling University, said: "We found that viruses can attach to microplastics and that allows them to survive in the water for three days, possibly longer." While previous research had been carried out in sterile settings, this is the first research into how viruses behave in the environment, Quilliam said. However, he used standard laboratory methods to determine whether viruses found on microplastics in water were infectious.

"We weren't sure how well viruses could survive by 'hitchhiking' on plastic in the environment, but they do survive and they do remain infectious," he said. The findings, part of a $2.27m project funded by the Natural Environment Research Council looking at how plastics transport bacteria and viruses, concluded that microplastics enabled pathogen transfer in the environment. The paper is published in the journal Environmental Pollution. "Being infectious in the environment for three days, that's long enough to get from the wastewater treatment works to the public beach," Quilliam said. Wastewater treatment plants were unable to capture microplastics, he said. "Even if a wastewater treatment plant is doing everything it can to clean sewage waste, the water discharged still has microplastics in it, which are then transported down the river, into the estuary and wind up on the beach."

"Researchers at Tsinghua University in China have developed a new drug cocktail that can convert cells into totipotent stem cells, the very seeds of life..." writes New Atlas: Not all stem cells are created equal — they sit in a branching hierarchy of differentiation potential. Multipotent stem cells are found in many tissues in adults, where they can turn into a few types of cells associated with that tissue or organ to help healing. A step earlier in the development tree are pluripotent stem cells, which are found in embryos and can become almost any type of cell in the body.

But at the top of the chain sit what are known as totipotent stem cells, which can become any cell in the body as well as supportive tissues like the placenta. These mark the very beginning of development, including the first single cell that forms from a fertilized egg, and they persist for the first few stages of development. After that, the cells differentiate into pluripotent stem cells and further specialize into all the cells of the body as it develops.

In recent years scientists have been able to take adult cells and induce a pluripotent state in them, which forms the basis of research into stem cell regenerative medicine. But in the new study, the Tsinghua team took things a step further, returning pluripotent stem cells to a totipotent state for the first time...

This breakthrough could open up some major new opportunities, the team says. In the long run, scientists could potentially create a living organism straight from a mature cell, sidestepping the need for sperm and eggs. That could help people have children who otherwise couldn't, or aid conservation of endangered species.

The researchers do acknowledge, however, that ethical concerns will no doubt arise.
Thanks to long-time Slashdot reader hackingbear for sharing the news.

"In late 2021, operators of the European Space Agency's Swarm constellation noticed something worrying," reports Space.com. "The satellites, which measure the magnetic field around Earth, started sinking toward the atmosphere at an unusually fast rate — up to 10 times faster than before.

"The change coincided with the onset of the new solar cycle, and experts think it might be the beginning of some difficult years for spacecraft orbiting our planet." "In the last five, six years, the satellites were sinking about two and a half kilometers [1.5 miles] a year," Anja Stromme, ESA's Swarm mission manager, told Space.com. "But since December last year, they have been virtually diving. The sink rate between December and April has been 20 kilometers [12 miles] per year."

Satellites orbiting close to Earth always face the drag of the residual atmosphere, which gradually slows the spacecraft and eventually makes them fall back to the planet. (They usually don't survive this so-called re-entry and burn up in the atmosphere.) This atmospheric drag forces the International Space Station's controllers to perform regular "reboost" maneuvers to maintain the station's orbit of 250 miles (400 km) above Earth. This drag also helps clean up the near-Earth environment from space junk.

Scientists know that the intensity of this drag depends on solar activity — the amount of solar wind spewed by the sun, which varies depending on the 11-year solar cycle.... [S]ince last fall, the star has been waking up, spewing more and more solar wind and generating sunspots, solar flares and coronal mass ejections at a growing rate. And the Earth's upper atmosphere has felt the effects. "There is a lot of complex physics that we still don't fully understand going on in the upper layers of the atmosphere where it interacts with the solar wind," Stromme said. "We know that this interaction causes an upwelling of the atmosphere. That means that the denser air shifts upwards to higher altitudes."

Denser air means higher drag for the satellites. Even though this density is still incredibly low 250 miles above Earth, the increase caused by the upwelling atmosphere is enough to virtually send some of the low-orbiting satellites plummeting. "It's almost like running with the wind against you," Stromme said. "It's harder, it's drag — so it slows the satellites down, and when they slow down, they sink...." The lower the orbit of the satellites when the solar storm hits, the higher the risk of the spacecraft not being able to recover, leaving operators helplessly watching as the craft fall to their demise in the atmosphere....

All spacecraft around the 250-mile altitude are bound to have problems, Stromme said. That includes the International Space Station, which will have to perform more frequent reboost maneuvers to keep afloat, but also the hundreds of cubesats and small satellites that have populated low Earth orbit in the past decade.... "Many of these [new satellites] don't have propulsion systems," Stromme said. "They don't have ways to get up. That basically means that they will have a shorter lifetime in orbit. They will reenter sooner than they would during the solar minimum."
Thanks to long-time Slashdot reader schwit1 for sharing the article!

"China's Mars sample return mission aims to collect samples from the Red Planet and deliver them to Earth in 2031, or two years ahead of a NASA and ESA joint mission," reports SpaceNews: Lifting off in late 2028... the complex, multi-launch mission will have simpler architecture in comparison with the joint NASA-ESA project, with a single Mars landing and no rovers sampling different sites. However, if successful, it would deliver to Earth the first collected Martian samples; an objective widely noted as one of the major scientific goals of space exploration....

The mission will build on the Mars entry, descent and landing technologies and techniques demonstrated by Tianwen-1 in May 2021, as well as the regolith sampling, automated lunar orbit rendezvous and docking, and high velocity atmospheric reentry success achieved by the 2020 Chang'e-5 lunar sample return mission.... Landing on Mars would take place around September 2029. Sampling techniques will include surface sampling, drilling and mobile intelligent sampling, potentially using a four-legged robot.

The ascent vehicle will consist of two stages, using either solid or liquid propulsion, and will be required to reach a speed of 4.5 kilometers per second, according to the presentation. After rendezvous and docking with the waiting orbiter, the spacecraft will depart Mars orbit in late October 2030 for a return to Earth in July 2031.

Sun Zezhou [chief designer of the Tianwen-1 Mars orbiter and rover mission], added that the Tianwen-1 orbiter will conduct an aerobraking test in Mars orbit later this year as part of the sample return mission preparation.
Thanks to Slashdot reader Hmmmmmm for sharing the story!

LinkedIn recently added 'dyslexic thinking' as an official skill.

And now the U.K. national newspaper the Telegraph reports on scientists arguing that dyslexia is not a "disorder" — but an evolutionarily beneficial willingness to explore: The experts suggested that dyslexia, which causes difficulty reading, writing and spelling, is a useful specialisation and not a "neurocognitive condition"....

About one in five people have dyslexia, and their tendency to push the envelope would have been balanced out by other members of a prehistoric society, leading to a well-rounded group with equally useful skill sets. However, Dr Helen Taylor, from the University of Strathclyde, and Dr Martin Vestergaard, from the University of Cambridge, said that dyslexia was now seen as a problem because modern education systems focused on the things sufferers struggled with and neglected what they excelled at. They reassessed past studies on dyslexic individuals and disagreed with the prevailing theory that it was a cognitive deficit....

[S]ince the invention of written language, dyslexia has been seen as a problem, not a talent. "Schools, academic institutes and workplaces are not designed to make the most of explorative learning," said Dr Taylor. "We urgently need to start nurturing this way of thinking to allow humanity to continue to adapt and solve key challenges." They posit that dyslexic people are naturally more skilled "in realms like discovery, invention and creativity" and that this specialisation stems from millennia of human evolution.... Without the streak of curiosity and willingness to investigate that is commonplace in dyslexic brains, groups of people would likely struggle to survive, they said.

"The deficit-centred view of dyslexia isn't telling the whole story," said Dr Taylor. "We believe that the areas of difficulty experienced by people with dyslexia result from a cognitive trade-off between exploration of new information and exploitation of existing knowledge, with the upside being an explorative bias that could explain enhanced abilities observed in certain realms like discovery, invention and creativity.
The researchers argue this "explorative specialization in people with dyslexia could help explain why they have difficulties with tasks related to exploitation, such as reading and writing.

"It could also explain why people with dyslexia appear to gravitate towards certain professions that require exploration-related abilities, such as arts, architecture, engineering and entrepreneurship."

Thanks to Slashdot reader Bruce66423 for sharing the story

Long-time Slashdot reader schwit1 shares an announcement from London's Imperial College of Science, Technology and Medicine: A single MRI scan of the brain could be enough to diagnose Alzheimer's disease, according to new research by Imperial College London.

The research uses machine learning technology to look at structural features within the brain, including in regions not previously associated with Alzheimer's. The advantage of the technique is its simplicity and the fact that it can identify the disease at an early stage when it can be very difficult to diagnose. Although there is no cure for Alzheimer's disease, getting a diagnosis quickly at an early stage helps patients. It allows them to access help and support, get treatment to manage their symptoms and plan for the future. Being able to accurately identify patients at an early stage of the disease will also help researchers to understand the brain changes that trigger the disease, and support development and trials of new treatments....

The researchers adapted an algorithm developed for use in classifying cancer tumours, and applied it to the brain. They divided the brain into 115 regions and allocated 660 different features, such as size, shape and texture, to assess each region. They then trained the algorithm to identify where changes to these features could accurately predict the existence of Alzheimer's disease... They found that in 98 per cent of cases, the MRI-based machine learning system alone could accurately predict whether the patient had Alzheimer's disease or not. It was also able to distinguish between early and late-stage Alzheimer's with fairly high accuracy, in 79 per cent of patients.

Professor Eric Aboagye, from Imperial's Department of Surgery and Cancer, who led the research, said: "Currently no other simple and widely available methods can predict Alzheimer's disease with this level of accuracy, so our research is an important step forward...." The new system spotted changes in areas of the brain not previously associated with Alzheimer's disease, [which] opens up potential new avenues for research into these areas and their links to Alzheimer's disease.
Professor Aboagye adds that this new approach "could also identify early-stage patients for clinical trials of new drug treatments or lifestyle changes, which is currently very hard to do."

An anonymous reader quotes a report from Ars Technica: Earlier this year, news broke of the first experimental xenotransplantation: A human patient with heart disease received a heart from a pig that had been genetically engineered to avoid rejection. While initially successful, the experiment ended two months later when the transplant failed, leading to the death of the patient. At the time, the team didn't disclose any details regarding what went wrong. But this week saw the publication of a research paper that goes through everything that happened to prepare for the transplant and the weeks following. Critically, this includes the eventual failure of the transplant, which was triggered by the death of many of the muscle cells in the transplanted heart. But the reason for that death isn't clear, and the typical signs of rejection by the immune system weren't present. So, we're going to have to wait a while to understand what went wrong.
[...]
After death, the team performed an autopsy on the transplanted heart. They found that it had nearly doubled in weight, largely because of fluid (and some red blood cells) leaking out of blood vessels in the absence of clotting. There was significant death of heart muscle cells, but that was scattered across the heart, rather than being a general phenomenon. Critically, most of the indications of a strong immune rejection were missing. The presence of an apparent pig cytomegalovirus was worrying, but the researchers indicate there's some question about whether the tests that picked it up might have been recognizing a closely related human virus -- one that's often associated with organ transplant problems.

So, for now, it's not clear what happened with this transplant or what the significance of the apparent viral infection is. Obviously, the team has lots of material to work with to try to figure out what went on, and there's a long, long list of potential experiments to do with it. And there are also additional xenotransplant trials in the works, so it may not be long before we have a better sense of whether this was something specific to this transplant or a general risk of xenotransplantation.

The grave of a rocket body that slammed into the moon more than three months ago has been found. Space.com reports: Early this year, astronomers determined that a mysterious rocket body was on course to crash into the lunar surface on March 4. Their calculations suggested that the impact would occur inside Hertzsprung Crater, a 354-mile-wide (570 kilometers) feature on the far side of the moon. Their math was on the money, it turns out. Researchers with NASA's Lunar Reconnaissance Orbiter (LRO) mission announced last night (June 23) that the spacecraft had spotted a new crater in Hertzsprung -- almost certainly the resting place of the rogue rocket.

Actually, LRO imagery shows that the impact created two craters, an eastern one about 59 feet (18 meters) wide superimposed over a western one roughly 52 feet (16 m) across. "The double crater was unexpected and may indicate that the rocket body had large masses at each end," Mark Robinson of Arizona State University, the principal investigator of the Lunar Reconnaissance Orbiter Camera (LROC), wrote in an update last night. "Typically a spent rocket has mass concentrated at the motor end; the rest of the rocket stage mainly consists of an empty fuel tank," he added. "Since the origin of the rocket body remains uncertain, the double nature of the crater may help to indicate its identity."

As Robinson noted, the moon-crashing rocket remains mysterious. Early speculation held that it was likely the upper stage of the SpaceX Falcon 9 rocket that launched the Deep Space Climate Observatory (DSCOVR) mission for NASA and the U.S. National Oceanic and Atmospheric Administration in February 2015. But further observations and calculations changed that thinking, leading many scientists to conclude that the rocket body was probably part of the Long March 3 booster that launched China's Chang'e 5T1 mission around the moon in October 2014. China has denied that claim.

Engineers in Sydney have demonstrated a quantum integrated circuit made up of just a few atoms. By precisely controlling the quantum states of the atoms, the new processor can simulate the structure and properties of molecules in a way that could unlock new materials and catalysts. New Atlas reports: The new quantum circuit comes from researchers at the University of New South Wales (UNSW) and a start-up company called Silicon Quantum Computing (SQC). It's essentially made up of 10 carbon-based quantum dots embedded in silicon, with six metallic gates that control the flow of electrons through the circuit. It sounds simple enough, but the key lies in the arrangement of these carbon atoms down to the sub-nanometer scale. Relative to each other, they're precisely positioned to mimic the atomic structure of a particular molecule, allowing scientists to simulate and study the structure and energy states of that molecule more accurately than ever before.

In this case, they arranged the carbon atoms into the shape of the organic compound polyacetylene, which is made up of a repeating chain of carbon and hydrogen atoms with an alternating pattern of single and double carbon bonds between them. To simulate those bonds, the team placed the carbon atoms at different distances apart. Next, the researchers ran an electrical current through the circuit to check whether it would match the signature of a natural polyacetylene molecule -- and sure enough, it did. In other tests, the team created two different versions of the chain by cutting bonds at different places, and the resulting currents matched theoretical predictions perfectly. The significance of this new quantum circuit, the team says, is that it could be used to study more complicated molecules, which could eventually yield new materials, pharmaceuticals, or catalysts. This 10-atom version is right on the limit of what classical computers can simulate, so the team's plans for a 20-atom quantum circuit would allow for simulation of more complex molecules for the first time. The research has been published in the journal Nature.

Engineers at the European Space Agency (ESA) are getting ready for a Windows 98 upgrade on an orbiter circling Mars. The Verge reports: The Mars Express spacecraft has been operating for more than 19 years, and the Mars Advanced Radar for Subsurface and Ionospheric Sounding (MARSIS) instrument onboard has been using software built using Windows 98. Thankfully for humanity and the Red Planet's sake, the ESA isn't upgrading its systems to Windows ME. The MARSIS instrument on ESA's Mars Express was key to the discovery of a huge underground aquifer of liquid water on the Red Planet in 2018. This major new software upgrade "will allow it to see beneath the surfaces of Mars and its moon Phobos in more detail than ever before," according to the ESA. The agency originally launched the Mars Express into space in 2003 as its first mission to the Red Planet, and it has spent nearly two decades exploring the planet's surface.

MARSIS uses low-frequency radio waves that bounce off the surface of Mars to search for water and study the Red Planet's atmosphere. The instrument's 130-foot antenna is capable of searching around three miles below the surface of Mars, and the software upgrades will enhance the signal reception and onboard data processing to improve the quality of data that's sent back to Earth. "We faced a number of challenges to improve the performance of MARSIS," explains Carlo Nenna, a software engineer at Enginium who is helping ESA with the upgrade. "Not least because the MARSIS software was originally designed over 20 years ago, using a development environment based on Microsoft Windows 98!"

Recent studies in humans and mice have shown that late nights and early mornings may cause long lasting damage to your brain. From a report: The sleep debt collectors are coming. They want you to know that there is no such thing as forgiveness, only a shifting expectation of how and when you're going to pay them back. You think of them as you lie in bed at night. How much will they ask for? Are you solvent? You fall asleep, then wake up in a cold sweat an hour later. You fall asleep, then wake up, drifting in and out of consciousness until morning. As most every human has discovered, a couple nights of bad sleep is often followed by grogginess, difficulty concentrating, irritability, mood swings and sleepiness.

For years, it was thought that these effects, accompanied by cognitive impairments like lousy performances on short-term memory tests, could be primarily attributed to a chemical called adenosine, a neurotransmitter that inhibits electrical impulses in the brain. Spikes of adenosine had been consistently observed in sleep-deprived rats and humans. Adenosine levels can be quickly righted after a few nights of good sleep, however. This gave rise to a scientific consensus that sleep debt could be forgiven with a couple of quality snoozes -- as reflected in casual statements like "I'll catch up on sleep" or "I'll be more awake tomorrow."

But a review article published recently in the journal Trends in Neurosciences contends that the folk concept of sleep as something that can be saved up and paid off is bunk. The review, which canvassed the last couple of decades of research on long term neural effects of sleep deprivation in both animals and humans, points to mounting evidence that getting too little sleep most likely leads to long-lasting brain damage and increased risk of neurodegenerative disorders like Alzheimer's disease. "This is really, really important in setting the stage for what needs to be done in sleep health and sleep science," said Mary Ellen Wells, a sleep scientist at the University of North Carolina, who did not contribute to the review.