The James Webb Space Telescope has snapped a pair of near-infrared photos showing Jupiter's polar auroras. "You can also see the planet's extremely faint rings and two of its smaller moons, Amalthea (the bright spot to the far left) and Adrastea (the dot at the left edge of the central ring)," notes Engadget. From the report: The pictures were taken using NIRCam's widefield view on July 27th. As for the trippy visuals? Astronomers created composites using several images produced with filters mapped to multiple colors (particularly visible in the image below). The Great Red Spot and other cloud formations are white as they reflect large amounts of sunlight. The observations should provide more insights into Jupiter's "inner life," according to the European Space Agency. That, in turn, could help scientists understand the behavior of gas giants beyond the Solar System.

An anonymous reader quotes a report from MIT News: Parkinson's disease is notoriously difficult to diagnose as it relies primarily on the appearance of motor symptoms such as tremors, stiffness, and slowness, but these symptoms often appear several years after the disease onset. Now, Dina Katabi, the Thuan (1990) and Nicole Pham Professor in the Department of Electrical Engineering and Computer Science (EECS) at MIT and principal investigator at MIT Jameel Clinic, and her team have developed an artificial intelligence model that can detect Parkinson's just from reading a person's breathing patterns. The tool in question is a neural network, a series of connected algorithms that mimic the way a human brain works, capable of assessing whether someone has Parkinson's from their nocturnal breathing -- i.e., breathing patterns that occur while sleeping. The neural network, which was trained by MIT PhD student Yuzhe Yang and postdoc Yuan Yuan, is also able to discern the severity of someone's Parkinson's disease and track the progression of their disease over time.

The MIT researchers demonstrated that the artificial intelligence assessment of Parkinson's can be done every night at home while the person is asleep and without touching their body. To do so, the team developed a device with the appearance of a home Wi-Fi router, but instead of providing internet access, the device emits radio signals, analyzes their reflections off the surrounding environment, and extracts the subject's breathing patterns without any bodily contact. The breathing signal is then fed to the neural network to assess Parkinson's in a passive manner, and there is zero effort needed from the patient and caregiver. "A relationship between Parkinson's and breathing was noted as early as 1817, in the work of Dr. James Parkinson. This motivated us to consider the potential of detecting the disease from one's breathing without looking at movements," Katabi says. "Some medical studies have shown that respiratory symptoms manifest years before motor symptoms, meaning that breathing attributes could be promising for risk assessment prior to Parkinson's diagnosis." The research has been published in the journal Nature Medicine.

Pulsing electrical currents through the brain for 20 minutes can boost memory for older adults for at least a month, according to a new study. From a report: Around 8 percent of people in the US get diagnosed with Alzheimer's disease or dementia as they get older -- significantly impairing their memory -- and an even larger group of older adults has some degree of age-related memory loss. This new study is only a first look at a potential solution. But easy, quick treatments like this one could become even more important as the world's population rapidly ages -- especially if future research shows that it can help with more serious cognitive conditions.

The brain stimulation done in this study, published Monday in Nature Neuroscience, came from a swim cap-like device studded with electrodes positioned to deliver the electric current to specific areas of the brain. The research team was interested in two main areas: one that's linked with working memory (which holds information temporarily and overlaps with short-term memory) and another linked with long-term memory. The research team divided 60 participants between the ages of 65 and 88 into three groups: one group wore the device but didn't get any electrical stimulation; the second received stimulation in the region associated with working memory; and the third received stimulation in the area associated with long-term memory.

Several readers have shared a report: The ads are everywhere -1 and so are the inflated claims: Special shampoos and treatments, sometimes costing thousands of dollars, will make hair grow. But many dermatologists who specialize in hair loss say that most of these products don't work. [...] But there is a cheap treatment, he and other dermatologists say, costing pennies a day, that restores hair in many patients. It is minoxidil, an old and well-known hair-loss treatment drug used in a very different way. Rather than being applied directly to the scalp, it is being prescribed in very low-dose pills.

Although a growing group of dermatologists is offering low-dose minoxidil pills, the treatment remains relatively unknown to most patients and many doctors. It has not been approved by the Food and Drug Administration for this purpose and so is prescribed off-label -- a common practice in dermatology. "I call us the off-label bandits -- a title I am proud to bear," said Dr. Adam Friedman, professor and chair of dermatology at George Washington University. He explained that dermatologists have been trained to understand how medicines work, which allows them to try drugs off-label.

This week the New England Journal of Medicine published results from a one year, randomized, placebo-controlled study on whether Ivermectin (or the drugs metformin and fluvoxamine) helped patients when administered at the beginning of a COVID-19 infection. Here's how MarketWatch summarized the results:

Ivermectin "failed to prevent the kind of severe COVID-19 that leads to an emergency-room visit or hospitalization." "None of the medications showed any impact on the primary outcome, which included experiencing low oxygen as measured on an home oxygen monitor," said Dr. Carolyn Bramonte, principal investigator of the study and an assistant professor of internal medicine and pediatrics at the University of Minnesota Medical School. Having low blood oxygen levels, or hypoxemia, is a common reason why COVID-19 patients end up seeking care in an ER, being hospitalized, or dying....

Each of the three generic medications has been held up as a possible COVID-19 drug, particularly ivermectin, which gained a cult following over the course of the pandemic despite well-documented issues with the flawed science that in some cases fraudulently touted the drug's benefits. Yet none so far have demonstrated in robust clinical trials that they actually help treat people with COVID-19.

A long-awaited double-blind, randomized, placebo-controlled study conducted by Duke University School of Medicine and funded by the U.S. concluded in June that ivermectin did not improve symptom duration among COVID-19 patients with mild-to-moderate forms of the disease. The same research found that the drug did not reduce hospitalizations or death.

"The very first results from the James Webb Space Telescope seem to indicate that massive, luminous galaxies had already formed within the first 250 million years after the Big Bang," reports Sky and Telescope.

"If confirmed, this would seriously challenge current cosmological thinking." Shortly after NASA published Webb's first batch of scientific data, the astronomical preprint server arXiv was flooded with papers claiming the detection of galaxies that are so remote that their light took some 13.5 billion years to reach us. Many of these appear to be more massive than the standard cosmological model that describes the universe's composition and evolution. "It worries me slightly that we find these monsters in the first few images," says cosmologist Richard Ellis (University College London)....

Before the community accepts these claims, the reported redshifts have to be confirmed spectroscopically. Mark McCaughrean, the senior science adviser of the European Space Agency (a major partner on Webb) commented on Twitter: "I'm sure some of them will be [confirmed], but I'm equally sure they won't all be. [...] It does all feel a little like a sugar rush at the moment."

Ellis agrees: "It's one thing to put a paper on arXiv," he says, "but it's quite something else to turn it into a lasting article in a peer-reviewed journal."
Since 1991, science writer Eric Lerner has been arguing that the Big Bang never happened. Now 75 years old, he writes: In the flood of technical astronomical papers published online since July 12, the authors report again and again that the images show surprisingly many galaxies, galaxies that are surprisingly smooth, surprisingly small and surprisingly old. Lots of surprises, and not necessarily pleasant ones. One paper's title begins with the candid exclamation: "Panic!"

Why do the JWST's images inspire panic among cosmologists? And what theory's predictions are they contradicting? The papers don't actually say. The truth that these papers don't report is that the hypothesis that the JWST's images are blatantly and repeatedly contradicting is the Big Bang Hypothesis that the universe began 14 billion years ago in an incredibly hot, dense state and has been expanding ever since. Since that hypothesis has been defended for decades as unquestionable truth by the vast majority of cosmological theorists, the new data is causing these theorists to panic. "Right now I find myself lying awake at three in the morning," says Alison Kirkpatrick, an astronomer at the University of Kansas in Lawrence, "and wondering if everything I've done is wrong...."

Even galaxies with greater luminosity and mass than our own Milky Way galaxy appear in these images to be two to three times smaller than in similar images observed with the Hubble Space Telescope (HST), and the new galaxies have redshifts which are also two to three times greater.This is not at all what is expected with an expanding universe, but it is just exactly what I and my colleague Riccardo Scarpa predicted based on a non-expanding universe, with redshift proportional to distance.... [T]he galaxies that the JWST shows are just the same size as the galaxies near to us, if it is assumed that the universe is not expanding and redshift is proportional to distance.....

Big Bang theorists did expect to see badly mangled galaxies scrambled by many collisions or mergers. What the JWST actually showed was overwhelmingly smooth disks and neat spiral forms, just as we see in today's galaxies. The data in the "Panic!" article showed that smooth spiral galaxies were about "10 times" as numerous as what theory had predicted and that this "would challenge our ideas about mergers being a very common process". In plain language, this data utterly destroys the merger theory....

According to Big Bang theory, the most distant galaxies in the JWST images are seen as they were only 400-500 million years after the origin of the universe. Yet already some of the galaxies have shown stellar populations that are over a billion years old. Since nothing could have originated before the Big Bang, the existence of these galaxies demonstrates that the Big Bang did not occur....

While Big Bang theorists were shocked and panicked by these new results, Riccardo and I (and a few others) were not. In fact, a week before the JWST images were released we published online a paper that detailed accurately what the images would show. We could do this with confidence because more and more data of all kinds has been contradicting the Big Bang hypothesis for years....

Based on the published literature, right now the Big Bang makes 16 wrong predictions and only one right one — the abundance of deuterium, an isotope of hydrogen.
UPDATE: Kirkpatrick says her quote was was taken out of context, in an article from Space.com that dismises Eric Lerner as "a serial denier of the Big Bang since the late 1980s, preferring his personal pseudoscientific alternative."

Globally, nearly half of deaths due to cancer can be attributable to preventable risk factors, including the three leading risks of: smoking, drinking too much alcohol or having a high body mass index, a new paper suggests. CNN reports: The research, published Thursday in the journal The Lancet, finds that 44.4% of all cancer deaths and 42% of healthy years lost could be attributable to preventable risk factors in 2019. "To our knowledge, this study represents the largest effort to date to determine the global burden of cancer attributable to risk factors, and it contributes to a growing body of evidence aimed at estimating the risk-attributable burden for specific cancers nationally, internationally, and globally," Dr. Chris Murray, director of the Institute for Health Metrics and Evaluation at the University of Washington, and his colleagues wrote in the study.

The paper, funded by the Bill & Melinda Gates Foundation, analyzed the relationship between risk factors and cancer, the second leading cause of death worldwide, using data from the Institute for Health Metrics and Evaluation's Global Burden of Disease project. The project collects and analyzes global data on deaths and disability. Murray and his colleagues zeroed in on cancer deaths and disability from 2010 to 2019 across 204 countries, examining 23 cancer types and 34 risk factors. The leading cancers in terms of risk-attributable deaths globally in 2019 was tracheal, bronchus and lung cancer for both men and women, the researchers found. The data also showed that risk-attributable cancer deaths are on the rise, increasing worldwide by 20.4% from 2010 to 2019. Globally, in 2019, the leading five regions in terms of risk-attributable death rates were central Europe, east Asia, North America, southern Latin America and western Europe.

An anonymous reader quotes a report from The Guardian: [R]esearchers say they have found the mechanism behind the insect's ability to home in on humans. Humans give off a fragrant cocktail of body odor, heat and carbon dioxide, which varies from person to person and mosquitoes use to locate their next meal. While most animals have a specific set of neurons that detect each type of odor, mosquitoes can pick up on smells via several different pathways, suggests the study, which is published in the science journal Cell. "We found that there's a real difference in the way mosquitoes encode the odors that they encounter compared to what we've learned from other animals," said Meg Younger, an assistant professor of biology at Boston University and one of the lead authors of the study.

Researchers at the Rockefeller University, in New York, were baffled when mosquitoes were somehow still able to find people to bite after having an entire family of human odor-sensing proteins removed from their genome. The team then examined odor receptors in the antennae of mosquitoes, which bind to chemicals floating around in the environment and signal to the brain via neurons. "We assumed that mosquitoes would follow the central dogma of olfaction, which is that only one type of receptor is expressed in each neuron," said Younger. "Instead, what we've seen is that different receptors can respond to different odors in the same neuron." This means losing one or more receptors does not affect the ability of mosquitoes to pick up on human smells. This backup system could have evolved as a survival mechanism, the researchers say. "The mosquito Aedes aegypti is specialized to bite humans, and it is believed that they evolved to do that because humans are always close to fresh water and mosquitoes lay their eggs in fresh water. We are basically the perfect meal, so the drive to find humans is extremely strong," said Younger.

An infection caused by a brain-eating amoeba most likely killed a child who swam in a Nebraska river over the weekend, health officials said Thursday. It would be the first such death in the state's history and the second in the Midwest this summer. From a report: The child, whose name was not released by officials, most likely contracted the infection, known as primary amebic meningoencephalitis, while swimming with family in a shallow part of the Elkhorn River in eastern Nebraska on Sunday, according to the Douglas County Health Department. At a news conference on Thursday, health officials said the typically fatal infection is caused by Naegleria fowleri, also known as brain-eating amoeba, and most likely led to the child's death.

Last month, a person in Missouri died because of the same amoeba infection, according to the Missouri Department of Health and Senior Services. The person had been swimming at the beach at Lake of Three Fires State Park in Iowa. Out of precaution, the Iowa Department of Public Health closed the lake's beach for about three weeks. The brain-eating amoebas, which are single-cell organisms, usually thrive in warm freshwater lakes, rivers, canals and ponds, though they can also be present in soil. They enter the body through the nose and then move into the brain. People usually become infected while swimming in lakes and rivers, according to the Centers for Disease Control and Prevention. Infections from brain-eating amoeba are extremely rare: From 2012 to 2021, only 31 cases were reported in the U.S., according to the C.D.C.

Europe is seriously considering developing space-based solar power to increase its energy independence and reduce greenhouse gas emissions, the leader of the European Space Agency said this week. Ars Technica reports: "It will be up to Europe, ESA and its Member States to push the envelope of technology to solve one of the most pressing problems for people on Earth of this generation," said Josef Aschbacher, director general of the space agency, an intergovernmental organization of 22 member states. Previously the space agency commissioned studies from consulting groups based in the United Kingdom and Germany to assess the costs and benefits of developing space-based solar power. ESA published those studies this week in order to provide technical and programmatic information to policymakers in Europe. Aschbacher has been working to build support within Europe for solar energy from space as a key to energy de-carbonization and will present his Solaris Program to the ESA Council in November. This council sets priorities and funding for ESA. Under Aschbacher's plans, development of the solar power system would begin in 2025.

In concept, space-based solar power is fairly straightforward. Satellites orbiting well above Earth's atmosphere collect solar energy and convert it into current; this energy is then beamed back to Earth via microwaves, where they are captured by photovoltaic cells or antennas and converted into electricity for residential or industrial use. The primary benefits of gathering solar power from space, rather than on the ground, is that there is no night or clouds to interfere with collection; and the solar incidence is much higher than at the northern latitudes of the European continent.

The two consulting reports discuss development of the technologies and funding needed to start to bring a space-based power system online. Europe presently consumes about 3,000 TWh of electricity on an annual basis, and the reports describe massive facilities in geostationary orbit that could meet about one-quarter to one-third of that demand. Development and deployment of these systems would cost hundreds of billions of euros. Why so much? Because facilitating space-based solar power would require a constellation of dozens of huge, sunlight-gathering satellites located 36,000 km from Earth. Each of these satellites would have a mass 10 times larger, or more, than that of the International Space Station, which is 450 metric tons and required more than a decade to assemble in low Earth orbit. Launching the components of these satellites would ultimately require hundreds or, more likely, thousands of launches by heavy lift rockets. "Using projected near-term space lift capability, such as SpaceX's Starship, and current launch constraints, delivering one satellite into orbit would take between 4 and 6 years," a report by British firm Frazer-Nash states. "Providing the number of satellites to satisfy the maximum contribution that SBSP could make to the energy mix in 2050 would require a 200-fold increase over current space-lift capacity." Critics of the concept include Elon Musk and physicist Casey Handmer, among others, which take issue with the poor photon to electron to photon conversion efficiency and prohibitively expensive transmission losses, thermal losses, and logistics costs.

An anonymous reader quotes a report from the New York Times: A team of scientists has found a cheap, effective way to destroy so-called forever chemicals, a group of compounds that pose a global threat to human health. The chemicals -- known as PFAS, or per- and polyfluoroalkyl substances -- are found in a spectrum of products and contaminate water and soil around the world. Left on their own, they are remarkably durable, remaining dangerous for generations. Scientists have been searching for ways to destroy them for years. In a study, published Thursday in the journal Science, a team of researchers rendered PFAS molecules harmless by mixing them with two inexpensive compounds at a low boil. In a matter of hours, the PFAS molecules fell apart. The new technique might provide a way to destroy PFAS chemicals once they've been pulled out of contaminated water or soil. But William Dichtel, a chemist at Northwestern University and a co-author of the study, said that a lot of effort lay ahead to make it work outside the confines of a lab. "Then we'd be in a real position to talk practicality," he said.

At the end of a PFAS molecule's carbon-fluorine chain, it is capped by a cluster of other atoms. Many types of PFAS molecules have heads made of a carbon atom connected to a pair of oxygen atoms, for example. Dr. Dichtel came across a study in which chemists at the University of Alberta found an easy way to pry carbon-oxygen heads off other chains. He suggested to his graduate student, Brittany Trang, that she give it a try on PFAS molecules. Dr. Trang was skeptical. She had tried to pry off carbon-oxygen heads from PFAS molecules for months without any luck. According to the Alberta recipe, all she'd need to do was mix PFAS with a common solvent called dimethyl sulfoxide, or DMSO, and bring it to a boil. "I didn't want to try it initially because I thought it was too simple," Dr. Trang said. "If this happens, people would have known this already." An older grad student advised her to give it a shot. To her surprise, the carbon-oxygen head fell off. It appears that DMSO makes the head fragile by altering the electric field around the PFAS molecule, and without the head, the bonds between the carbon atoms and the fluorine atoms become weak as well. "This oddly simple method worked," said Dr. Trang, who finished her Ph.D. last month and is now a journalist.

Unfortunately, Dr. Trang discovered how well DMSO worked in March 2020 and was promptly shut out of the lab by the pandemic. She spent the next two and a half months dreaming of other ingredients which she could add to the DMSO soup to hasten the destruction of PFAS chemicals. On Dr. Trang's return, she started testing a number of chemicals until she found one that worked. It was sodium hydroxide, the chemical in lye. When she heated the mixture to temperatures between about 175 degrees to 250 degrees Fahrenheit, most of the PFAS molecules broke down in a matter of hours. Within days, the remaining fluorine-bearing byproducts broke down into harmless molecules as well. Dr. Trang and Dr. Dichtel teamed up with other chemists at U.C.L.A. and in China to figure out what was happening. The sodium hydroxide hastens the destruction of the PFAS molecules by eagerly bonding with the fragments as they fall apart. The fluorine atoms lose their link to the carbon atoms, becoming harmless. [...] Dr. Dichtel and his colleagues are now investigating how to scale up their method to handle large amounts of PFAS chemicals. They're also looking at other types of PFAS molecules with different heads to see if they can pry those off as well.

It turns out that JavaScript had a hand in delivering the stunning images that the James Webb Space Telescope has been beaming back to Earth. From a report: I mean that the actual telescope, arguably one of humanity's finest scientific achievements, is largely controlled by JavaScript files. Oh, and it's based on a software development kit from 2002. According to a manuscript (PDF) for the JWST's Integrated Science Instrument Module (or ISIM), the software for the ISIM is controlled by "the Script Processor Task (SP), which runs scripts written in JavaScript upon receiving a command to do so." The actual code in charge of turning those JavaScripts (NASA's phrasing, not mine) into actions can run 10 of them at once.

The manuscript and the paper (PDF) "JWST: Maximizing efficiency and minimizing ground systems," written by the Space Telescope Science Institute's Ilana Dashevsky and Vicki Balzano, describe this process in great detail, but I'll oversimplify a bit to save you the pages of reading. The JWST has a bunch of these pre-written scripts for doing specific tasks, and scientists on the ground can tell it to run those tasks. When they do, those JavaScripts will be interpreted by a program called the script processor, which will then reach out to the other applications and systems that it needs to based on what the script calls for. The JWST isn't running a web browser where JavaScript directly controls the Mid-Infrared Instrument -- it's more like when a manager is given a list of tasks (in this example, the JavaScripts) to do and delegates them out to their team.

Whether you opt for repellant, long sleeves or citronella coils, the dreaded drone of a mosquito always seems to find its way back to you. Now researchers say they have found the mechanism behind the insect's ability to home in on humans. From a report: Humans give off a fragrant cocktail of body odour, heat and carbon dioxide, which varies from person to person and mosquitoes use to locate their next meal. While most animals have a specific set of neurons that detect each type of odour, mosquitoes can pick up on smells via several different pathways, suggests the study, which is published in the science journal Cell. "We found that there's a real difference in the way mosquitoes encode the odours that they encounter compared to what we've learned from other animals," said Meg Younger, an assistant professor of biology at Boston University and one of the lead authors of the study. Researchers at the Rockefeller University, in New York, were baffled when mosquitoes were somehow still able to find people to bite after having an entire family of human odour-sensing proteins removed from their genome. The team then examined odour receptors in the antennae of mosquitoes, which bind to chemicals floating around in the environment and signal to the brain via neurons.

sciencehabit writes: From the start of the pandemic, the Chinese government -- like many foreign researchers -- has vigorously rejected the idea that SARS-CoV-2 somehow originated in the Wuhan Institute of Virology (WIV) and escaped. But over the past 2 years, it has also started to push back against what many regard as the only plausible alternative scenario: The pandemic started in China with a virus that naturally jumped from bats to an "intermediate" species and then to humans -- most likely at the Huanan Seafood Market in Wuhan. Beijing was open to the idea at first. But today it points to myriad ways SARS-CoV-2 could have arrived in Wuhan from abroad, borne by contaminated frozen food or infected foreigners -- perhaps at the Military World Games in Wuhan, in October 2019 -- or released accidentally by a U.S. military lab located more than 12,000 kilometers from Wuhan. Its goal is to avoid being blamed for the pandemic in any way, says Filippa Lentzos, a sociologist at King's College London who studies biological threats and health security. "China just doesn't want to look bad," she says. "They need to maintain an image of control and competence. And that is what goes through everything they do."

The idea of a pandemic origin outside China is preposterous to many scientists, regardless of their position on whether the virus started with a lab leak or a natural jump from animals. There's simply no way SARS-CoV-2 could have come from some foreign place to Wuhan and triggered an explosive outbreak there without first racing through humans at the site of its origin. "The idea that the pandemic didn't originate in China is inconsistent with so many other things," says Jesse Bloom, a virologist at the Fred Hutchinson Cancer Research Center who has argued for more intensive studies of the WIV lab accident scenario. "When you eliminate the absurd, it's Wuhan," says virologist Gregory Towers of University College London, who leans toward a natural origin. Yet Chinese researchers have published a flurry of papers supporting their government's "anywhere-but-here" position. Multiple studies report finding no signs of SARS-CoV-2 related viruses or antibodies in bats and other wild and captive animals in China. Others offer clues that the virus hitched a ride to China on imported food or its packaging. On the flip side, Chinese researchers are not pursuing -- or at least not publishing -- obvious efforts to trace the sources of the mammals sold at the Huanan market, which could yield clues to the virus' origins.

FallOutBoyTonto shares a report from Ars Technica: Never let it be said that Rocket Lab founder Peter Beck lacks a flamboyant streak. [...] On Tuesday evening Rocket Lab announced that it will self-fund the development of a small spacecraft, and its launch, that will send a tiny probe flying through the clouds of Venus for about 5 minutes, at an altitude of 48 to 60 km. Beck has joined up with several noted planetary scientists, including Massachusetts Institute of Technology professor Sara Seager, to design this mission. Electron will deliver the spacecraft into a 165 km orbit above Earth, where the rocket's high-energy Photon upper stage will perform a number of burns to raise the spacecraft's orbit and reach escape velocity. Assuming a May 2023 launch -- there is a backup opportunity in January 2025 -- the spacecraft would reach Venus in October 2023. Once there, Photon would deploy a small, approximately 20 kg probe into the Venusian atmosphere.

The spacecraft will be tiny, as deep-space probes go, containing a 1 kg scientific payload consisting of an autofluorescing nephelometer, which is an instrument to detect suspended particles in the clouds. The goal is to search for organic chemicals in the clouds and explore their habitability. The probe will spend about 5 minutes and 30 seconds falling through the upper atmosphere, and then ideally continue transmitting data as it descends further toward the surface. "The mission is the first opportunity to probe the Venus cloud particles directly in nearly four decades," states a paper, published this week, describing the mission architecture. "Even with the mass and data rate constraints and the limited time in the Venus atmosphere, breakthrough science is possible."

An anonymous reader quotes a report from Reuters: The U.S. Food and Drug Administration on Wednesday approved bluebird bio's gene therapy for patients with a rare disorder requiring regular blood transfusions, and the drugmaker priced it at a record $2.8 million. The approval sent the company's shares 8% higher and is for the treatment of beta-thalassemia, which causes an oxygen shortage in the body and often leads to liver and heart issues. The sickest patients, estimated to be up to 1,500 in the United States, need blood transfusions every two to five weeks. The therapy, to be branded as Zynteglo, is expected to face some resistance from insurers due to its steep price, analysts say.

Bluebird has pitched Zynteglo as a potential one-time treatment that could do away with the need for transfusions, resulting in savings for patients over the long term. The average cost of transfusions over the lifetime can be $6.4 million, Chief Operating Officer Tom Klima told Reuters before the approval. "We feel the prices we are considering still bring a significant value to patients." Bluebird has been in talks with insurers about a one-time payment option. "Potentially, up to 80% of that payment will be reimbursed if a patient does not achieve transfusion independence, they (insurers) are very excited about that," Klima said. The FDA warned of a potential risk of blood cancer with the treatment but noted studies had no such cases. "Bluebird expects to start the treatment process for patients in the fourth quarter," reports Reuters. "No revenue is, however, expected from the therapy in 2022 as the treatment cycle would take an average of 70 to 90 days from initial cell collection to final transfusion."

Researchers have discovered a second impact crater on the other side of the Atlantic that could have finished off what was left of the dinosaurs, after an asteroid known as Chicxulub slammed into what is now the Gulf of Mexico 66 million years ago. The BBC reports: Dubbed Nadir Crater, the new feature sits more than 300m below the seabed, some 400km off the coast of Guinea, west Africa. With a diameter of 8.5km, it's likely the asteroid that created it was a little under half a kilometre across. The hidden depression was identified by Dr Uisdean Nicholson from Heriot-Watt University, Edinburgh, UK. [...] "Our simulations suggest this crater was caused by the collision of a 400m-wide asteroid in 500-800m of water," explained Dr Veronica Bray from the University of Arizona, US. "This would have generated a tsunami over one kilometre high, as well as an earthquake of Magnitude 6.5 or so. "The energy released would have been around 1,000 times greater than that from the January 2022 eruption and tsunami in Tonga."

Dr Nicholson's team has to be cautious about tying the two impacts together. Nadir has been given a very similar date to Chicxulub based on an analysis of fossils of known age that were drilled from a nearby borehole. But to make a definitive statement, rocks in the crater itself would need to be pulled up and examined. This would also confirm Nadir is indeed an asteroid impact structure and not some other, unrelated feature caused by, for example, ancient volcanism. [...] Prof Sean Gulick, who co-led the recent project to drill into the Chicxulub Crater, said Nadir might have fallen to Earth on the same day. Or it might have struck the planet a million or two years either side of the Mexican cataclysm. Scientists will only know for sure when rocks from the west African crater are inspected in the lab. "A much smaller cousin, or sister, doesn't necessarily add to what we know about the dinosaurs' extinction, but it does add to our understanding of the astronomical event that was Chicxulub," the University of Texas at Austin researcher told BBC News.

Redwire says it would launch the first commercial space greenhouse in Spring next year to boost crop production research outside Earth and support exploration missions. From a report: The space infrastructure company's project will help deliver critical insights for NASA's Artemis missions and beyond, said Dave Reed, Redwire's manager for the greenhouse project. The Artemis program of the National Aeronautics and Space Administration (NASA) aims at sending astronauts to the moon and establishing a long-term lunar colony as a precursor to the eventual human exploration of Mars.

The navigation strategy of NASA's Curiosity rover means it has to stop frequently to check its position, but soon a software update will allow it to move almost continuously. From a report: A new software update will soon give NASA's Curiosity Mars rover a 50 per cent speed boost, allowing it to cover a greater distance and complete more science. But the update very nearly didn't happen because of a mysterious bug in the software that eluded engineers for years. Curiosity, which landed on Mars 10 years ago this month, has already greatly outlived its planned two-year lifespan.

schwit1 shares a report from ScienceAlert: The molecule is called fabimycin, and further down the line it could be used to fight off some of the most stubborn infections that humans can get. The new potential treatment targets gram-negative bacteria, a group of hard-to-kill pathogens that are commonly behind infections of the urinary tract, lungs, and even the bloodstream. Their resilience is due to a protective outer membrane that helps shield the wall from damaging substances like antibiotics. One study at an English hospital found more than a third of individuals with gram-negative bacteria blood infections had died within a year, demonstrating the challenges involved in managing these robust microbes.

Fabimycin overcomes these problems by passing through the outer cell layer, avoiding the pumps that remove foreign material to allow the molecule to accumulate where it can do the most harm. The substance also manages to avoid wiping out too many healthy bacteria, another issue with current treatments. The team started off with an antibiotic that was known to be effective against gram-positive bacteria and made several structural changes to give the molecule the power to infiltrate gram-negative strains' powerful defenses. In tests, fabimycin had an effect on more than 300 types of drug-resistant bacteria. What's more, in mice models it was shown to reduce levels of harmful bacteria in mice with pneumonia or urinary tract infections to where they were pre-infection. The research has been published in the journal ACS Central Science.