"John Galvan was arrested at 18 and spent 35 years in prison for a crime he didn't commit," writes the Innocence Project, a nonprofit specializing in legal exoneration.

"In 2007, John Galvan was about 21 years into a life sentence for a crime he didn't commit when he saw something on the prison television he thought might finally help him prove his innocence and secure his freedom: A re-run of an episode of the Discovery Channel's MythBusters."

At the time of his arrest, they write, Galvan had been handcuffed to a wall for hours, physically beaten, and ultimately "agreed to give a confession that was completely fabricated by the detectives to end the abuse" — that Galvan had started a fire in an apartment building "by throwing a bottle filled with gasoline at the building and then tossing a cigarette into the pool of gasoline on the porch to ignite it." And then 21 years later... In his cell, a 39-year-old John watched as the hosts of MythBusters struggled repeatedly to ignite a pool of gasoline with a lit cigarette, despite fervent attempts. Based on the ignition temperature of gasoline and the temperature range of a lit cigarette, the show's hosts had initially hypothesized that a lit cigarette might be able to ignite spilled gasoline as they had seen on TV and in movies. But after several failed attempts to start a fire, including rolling a lit cigarette directly into a pool of gasoline, the team determined it was highly unlikely that dropping a cigarette into gasoline could cause a fire....

The show's findings were confirmed in 2007, by experiments conducted by the U.S. Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF), which made more than 2,000 attempts to ignite gasoline with a cigarette under various conditions. The bureau's experiments even included a vacuum that increased the cigarette's temperature to the level it would typically reach when being sucked and spraying a mist of gasoline directly onto the lit cigarette. All of the attempts failed. "Despite what you see in action movies, dropping a lit cigarette on to a trail of gasoline won't ignite it, assuming normal oxygen levels and no unusual circumstances," said Richard Tontarski, a forensic scientist and then chief of the ATF's fire research laboratory.

In 2017, when John finally had his evidentiary hearing on his post-conviction claims, [his attorney Tara] Thompson and his legal team presented multiple alibi witnesses, in addition to seven witnesses who testified to being tortured by the same officers who had coerced his confession, documents showing that police had fabricated probable cause to arrest him, and an arson expert who testified that John's false confession was scientifically impossible.... In 2019, the appellate court granted John post-conviction relief on the grounds of actual innocence — a rarity in Illinois — largely based on the abuse used to coerce a false confession from John.

The court concluded that without John's false confession, which he did not give voluntarily, "the State's case was nonexistent."
Thanks to long-time Slashdot reader Sleeping Kirby for sharing the story!

"After 433 gamblers won a lottery drawing in the Philippines last weekend, people across the country debated a thorny question," reports the New York Times. "At what point does randomness begin to look a little too much like a racket?" Some Filipinos accused the state-owned company behind the roughly $4 million prize drawing of fraud, a charge that was swiftly denied. Lawmakers said that they planned to investigate the winning draw as a way of securing the lottery's integrity. How was it possible, skeptics asked, that 433 people had all picked the same winning combination of six numbers — 09-45-36-27-18-54? Or that all six figures turned out to be multiples of nine?

Others said that the outcome was a simple case of good luck. (The winning numbers could be in any order.) Statisticians noted that it was not mathematically impossible for 433 winners to strike it big....

A few [critics] noted that some officials from the Philippine Charity Sweepstakes Office, which sold nearly $443 million in tickets in the first half of this year, have been convicted of bribery and other charges over the past decade, including one case in which they pocketed prize money.... Lawmakers in both the House and Senate said this week that they planned to investigate the contentious draw. One of those legislators, Aquilino Pimentel III, the minority leader of the Senate, told The Times in a text message on Wednesday that while the result was "not impossible," it seemed "highly improbable...."

Professor Chua Tin Chiu, a statistician at the National University of Singapore, said the criticism was an example of humans misunderstanding the nature of randomness. "Some time ago, there was news about a person that struck the jackpot more than once in his lifetime," he said. "Would that be possible? Yes. Are the chances very low? Yes. Is it going to happen to someone? Yes."

In an exclusive excerpt from William Shatner's new book, "Boldly Go: Reflections on a Life of Awe and Wonder," the Star Trek actor reflects on his voyage into space on Jeff Bezos' Blue Origin space shuttle on Oct. 13, 2021. Then 90 years old, Shatner became the oldest living person to travel into space, but as the actor and author details below, he was surprised by his own reaction to the experience. An anonymous reader shares an excerpt from the report: I looked down and I could see the hole that our spaceship had punched in the thin, blue-tinged layer of oxygen around Earth. It was as if there was a wake trailing behind where we had just been, and just as soon as I'd noticed it, it disappeared. I continued my self-guided tour and turned my head to face the other direction, to stare into space. I love the mystery of the universe. I love all the questions that have come to us over thousands of years of exploration and hypotheses. Stars exploding years ago, their light traveling to us years later; black holes absorbing energy; satellites showing us entire galaxies in areas thought to be devoid of matter entirely all of that has thrilled me for years but when I looked in the opposite direction, into space, there was no mystery, no majestic awe to behold... all I saw was death. I saw a cold, dark, black emptiness. It was unlike any blackness you can see or feel on Earth. It was deep, enveloping, all-encompassing. I turned back toward the light of home. I could see the curvature of Earth, the beige of the desert, the white of the clouds and the blue of the sky. It was life. Nurturing, sustaining, life. Mother Earth. Gaia. And I was leaving her. Everything I had thought was wrong. Everything I had expected to see was wrong.

I had thought that going into space would be the ultimate catharsis of that connection I had been looking for between all living things -- that being up there would be the next beautiful step to understanding the harmony of the universe. In the film "Contact," when Jodie Foster's character goes to space and looks out into the heavens, she lets out an astonished whisper, "They should've sent a poet." I had a different experience, because I discovered that the beauty isn't out there, it's down here, with all of us. Leaving that behind made my connection to our tiny planet even more profound. It was among the strongest feelings of grief I have ever encountered. The contrast between the vicious coldness of space and the warm nurturing of Earth below filled me with overwhelming sadness. Every day, we are confronted with the knowledge of further destruction of Earth at our hands: the extinction of animal species, of flora and fauna... things that took five billion years to evolve, and suddenly we will never see them again because of the interference of mankind. It filled me with dread. My trip to space was supposed to be a celebration; instead, it felt like a funeral.

I learned later that I was not alone in this feeling. It is called the "Overview Effect" and is not uncommon among astronauts, including Yuri Gagarin, Michael Collins, Sally Ride, and many others. Essentially, when someone travels to space and views Earth from orbit, a sense of the planet's fragility takes hold in an ineffable, instinctive manner. Author Frank White first coined the term in 1987: "There are no borders or boundaries on our planet except those that we create in our minds or through human behaviors. All the ideas and concepts that divide us when we are on the surface begin to fade from orbit and the moon. The result is a shift in worldview, and in identity." It can change the way we look at the planet but also other things like countries, ethnicities, religions; it can prompt an instant reevaluation of our shared harmony and a shift in focus to all the wonderful things we have in common instead of what makes us different. It reinforced tenfold my own view on the power of our beautiful, mysterious collective human entanglement, and eventually, it returned a feeling of hope to my heart. In this insignificance we share, we have one gift that other species perhaps do not: we are aware -- not only of our insignificance, but the grandeur around us that makes us insignificant. That allows us perhaps a chance to rededicate ourselves to our planet, to each other, to life and love all around us. If we seize that chance.

In the Italian city of Naples, some climate change solutions may be as ancient as the coastal outpost itself, according to researchers who are studying how the area's historic waterways could bring relief from extreme heat as the world warms. From a report: Architects and design students in Italy and the United States are collaborating on an initiative to map ancient aqueducts and water systems in Naples. Known as the Cool City Project, the goal is to assess how this existing infrastructure -- in some cases, centuries old and hidden underground -- could combat life-threatening heat waves in one of the most densely populated parts of Europe and one of the oldest cities in the world. "Naples is sometimes called the capital of the midday sun because of where it's located in the south of Italy," said Nick De Pace, an architect and professor at the Rhode Island School of Design. "It's a dense city in an area that is already dealing with geothermal heating. And then on top of that, you have climate change."

[...] To start, the researchers are using laser-scanning technology to map Naples' extensive aqueduct system and underground canals. The idea is to examine if reviving these ancient waterways, or resurfacing them, could counter the urban heat island effect. "Daylighting portions of a canal could have a cooling effect in the summer, just like how you can feel a cooling effect from basements," De Pace said. "Then, you can also divert some of that water to new green spaces in the city where you have plants and other things to cool things down." Naples is a compelling place to test such ideas because the city already has a rich history with water, said Alexander Valentino, an architect and Cool City collaborator who is based in Naples.

A new study suggests that a billboard-like constellation of about 50 satellites, costing $65 million all in, could shine ads to every corner of the Earth for months -- and potentially make money while doing so. TechCrunch reports: The study, from Russian researchers at the Skolkovo Institute of Science and Technology (Skoltech) and Moscow Institute of Physics and Technology (MIPT), presents a fairly compelling case that is bolstered by the recent controversy around SpaceX's highly visible Starlink satellites. The paper's proposal involves sending up a constellation of about 50 satellites at a 12U CubeSat volume -- think about the size of a full paper grocery bag. The satellites would enter a sun-synchronous orbit, meaning they'll always be in direct sunlight as they pass around the Earth. Once in orbit, they would deploy large, parabolic reflectors that would bounce sunlight down toward the Earth. These could be tilted to best present the sunlight to a target area they are passing over, and from the ground would appear to be a group of stars moving in synchrony for a period of perhaps three to five minutes. (To be clear, the image at top is just for illustration -- it would be much dimmer in reality.)

The 50 satellites could rearrange themselves in patterns, from letters to simple graphics -- not fast, but fast enough that the shape could evolve over their visible time, or change advertisers between target cities. They would deorbit after 1-3 months, depending on several factors. I've asked the researchers for clarification on the lifetime, display length and a few other details and will update this post if I hear back. The physical possibility of doing this doesn't seem outlandish at all considering how visible existing satellites can be in these orbits, and the precision with which they can be arranged already. So with that established, a good deal of the paper is dedicated to an economic analysis. After all, we probably could have launched a Nike logo to space in the '90s (and there were attempts) if the world came together on it... but why would they? The thing has to make financial sense.

The cost of the mission is estimated at $65 million, most of which goes to manufacturing the 50 satellites ($48.7 million), then to testing, support and engineering ($11.5 million), and of course launch ($4.8 million). That seems reasonable enough in theory. But it gets a little fuzzy in the income estimates. A complicated equation for determining which cities, in which regions and at what times of the year would make more money suggests that winter provides the greatest ROI. You might think: but people stay inside during the winter. Yes, but not in the tropics and much of south and southeast Asia, where winter brings longer nights but nothing like the inclement weather of northern latitudes. And it happens some of the most densely populated cities in the world are there. Their most optimistic estimate puts net income at around $111 million, over three months and 24 displays -- that works out to around $4.6 million per ad. Super Bowl ads cost more than that, and only last 30 seconds -- though of course they're in 4K and full color with sound. But the money and appetite for stunt advertising is definitely there.

Toxic air pollution particles have been found in the lungs, livers and brains of unborn babies, long before they have taken their first breath. Researchers said their "groundbreaking" discovery was "very worrying," as the gestation period of foetuses is the most vulnerable stage of human development. From a report: Thousands of black carbon particles were found in each cubic millimetre of tissue, which were breathed in by the mother during pregnancy and then passed through the bloodstream and placenta to the foetus. Dirty air was already known to strongly correlate with increased miscarriages, premature births, low birth weights and disturbed brain development. But the new study provides direct evidence of how that harm may be caused. The scientists said the pollution could cause lifelong health effects.

The particles are made of soot from the burning of fossil fuels in vehicles, homes and factories and cause inflammation in the body, as well as carrying toxic chemicals. The study was conducted with non-smoking mothers in Scotland and Belgium, in places with relatively low air pollution. "We have shown for the first time that black carbon nanoparticles not only get into the first and second trimester placenta, but then also find their way into the organs of the developing foetus," said Prof Paul Fowler, at the University of Aberdeen in Scotland. "What is even more worrying is that these particles also get into the developing human brain," he said. "This means that it is possible for these nanoparticles to directly interact with control systems within human foetal organs and cells."

An anonymous reader quotes a report from the Guardian: An artificial intelligence tool that scans eyes can accurately predict a person's risk of heart disease in less than a minute, researchers say. [...] Researchers developed a fully automated AI-enabled tool, Quartz, to assess the potential of retinal vasculature imaging -- plus known risk factors -- to predict vascular health and death. They used the tool to scan images from 88,052 UK Biobank participants aged 40 to 69. The researchers looked specifically at the width, vessel area and degree of curviness of the arteries and veins in the retina to develop prediction models for stroke, heart attack and death from circulatory disease. They subsequently applied the models to the retinal images of 7,411 participants, aged 48 to 92, of the European prospective investigation into cancer (Epic)-Norfolk study. The performance of Quartz was compared with the widely used Framingham risk scores framework.

Everyone's health was tracked for an average of seven to nine years. In men, the width, curviness and width variation of veins and arteries in their retinas were found to be important predictors of death from circulatory disease. In women, artery area and width and vein curviness and width variation contributed to risk prediction. The AI tool harnessed data from participants including any history of smoking, drugs to treat high blood pressure, and previous heart attacks. Researchers found the retina data computed by Quartz was significantly associated with cardiovascular disease, deaths and strokes, with similar predictive performance to the Framingham clinical risk score. Their findings were published in the British Journal of Ophthalmology.

The NOEMA radio telescope, located on the Plateau de Bure in the French Alps, is now equipped with twelve antennas, making it the most powerful radio telescope of its kind in the northern hemisphere. Phys.Org reports: Eight years after the inauguration of the first NOEMA antenna in 2014, the large-scale European project is now complete. Thanks to its twelve 15-meter antennas, which can be moved back and forth on a specially developed rail system up to a distance of 1.7 kilometers long, NOEMA is a unique instrument for astronomical research. The telescope is equipped with highly sensitive receiving systems that operate close at the quantum limit. During observations, the observatory's twelve antennas act as a single telescope -- a technique called interferometry. After all the antennas have been pointed towards one and the same region of space, the signals they receive are combined with the help of a supercomputer. Their detailed resolution then corresponds to that of a huge telescope whose diameter is equal to the distance between the outermost antennas.

The respective arrangement of the antennas can extend over distances from a few hundred meters to 1.7 kilometers. The network thus functions like a camera with a variable lens. The further apart the antennas are, the more powerful is the zoom: the maximum spatial resolution of NOEMA is so high that it would be able to detect a mobile phone at a distance of over 500 kilometers. NOEMA is one of the few radio observatories worldwide that can simultaneously detect and measure a large number of signatures -- i.e., "fingerprints" of molecules and atoms. Thanks to these so-called multi-line observations, combined with high sensitivity, NOEMA is a unique instrument for investigating the complexity of cold matter in interstellar space as well as the building blocks of the university. With NOEMA, over 5,000 researchers from all over the world study the composition and dynamics of galaxies as well as the birth and death of stars, comets in our solar system or the environment of black holes. The observatory captures light from cosmic objects that has traveled to Earth for more than 13 billion years. NOEMA has "observed the most distant known galaxy, which formed shortly after the Big Bang," notes the report. It also "measured the temperature of the cosmic background radiation at a very early stage of the universe, a scientific first that should make it possible to trace the effects of dark energy driving the universe apart."

An anonymous reader quotes a report from MIT Technology Review: DeepMind has used its board-game playing AI AlphaZero to discover a faster way to solve a fundamental math problem in computer science, beating a record that has stood for more than 50 years. A year after it took biologists by surprise, AlphaFold has changed how researchers work and set DeepMind on a new course. The problem, matrix multiplication, is a crucial type of calculation at the heart of many different applications, from displaying images on a screen to simulating complex physics. It is also fundamental to machine learning itself. Speeding up this calculation could have a big impact on thousands of everyday computer tasks, cutting costs and saving energy.

Despite the calculation's ubiquity, it is still not well understood. A matrix is simply a grid of numbers, representing anything you want. Multiplying two matrices together typically involves multiplying the rows of one with the columns of the other. The basic technique for solving the problem is taught in high school. But things get complicated when you try to find a faster method. This is because there are more ways to multiply two matrices together than there are atoms in the universe (10 to the power of 33, for some of the cases the researchers looked at).

The trick was to turn the problem into a kind of three-dimensional board game, called TensorGame. The board represents the multiplication problem to be solved, and each move represents the next step in solving that problem. The series of moves made in a game therefore represents an algorithm. The researchers trained a new version of AlphaZero, called AlphaTensor, to play this game. Instead of learning the best series of moves to make in Go or chess, AlphaTensor learned the best series of steps to make when multiplying matrices. It was rewarded for winning the game in as few moves as possible. [...] The researchers describe their work in a paper published in Nature today. The headline result is that AlphaTensor discovered a way to multiply together two four-by-four matrices that is faster than a method devised in 1969 by the German mathematician Volker Strassen, which nobody had been able to improve on since. The basic high school method takes 64 steps; Strassen's takes 49 steps. AlphaTensor found a way to do it in 47 steps. "Overall, AlphaTensor beat the best existing algorithms for more than 70 different sizes of matrix," concludes the report. "It reduced the number of steps needed to multiply two nine-by-nine matrices from 511 to 498, and the number required for multiplying two 11-by-11 matrices from 919 to 896. In many other cases, AlphaTensor rediscovered the best existing algorithm."

Chris Baraniuk, reporting for Wired: The unborn baby was in trouble. Its mother's doctors, at a UK hospital, knew there was something wrong with the fetus's blood, so they decided to perform an emergency C-section many weeks before the baby was due. But despite this, and subsequent blood transfusions, the baby suffered a brain hemorrhage with devastating consequences. It sadly passed away. It wasn't clear why the bleeding had happened. But there was a clue in the mother's blood, where doctors had noticed some strange antibodies. Some time later, as the medics tried to find out more about them, a sample of the mother's blood arrived at a lab in Bristol run by researchers who study blood groups. They made a startling discovery: The woman's blood was of an ultrarare type, which may have made her baby's blood incompatible with her own.

It's possible that this prompted her immune system to produce antibodies against her baby's blood -- antibodies that then crossed the placenta and harmed her child, ultimately leading to its loss. It may seem implausible that such a thing could happen, but many decades ago, before doctors had a better understanding of blood groups, it was much more common. Through studying the mother's blood sample, along with a number of others, scientists were able to unpick exactly what made her blood different, and in the process confirmed a new set of blood grouping -- the "Er" system, the 44th to be described. You're probably familiar with the four main blood types -- A, B, O, and AB. But this isn't the only blood classification system. There are many ways of grouping red blood cells based on differences in the sugars or proteins that coat their surface, known as antigens.

The grouping systems run concurrently, so your blood can be classified in each -- it might, for instance, be type O in the ABO system, positive (rather than negative) under the Rhesus system, and so on. Thanks to differences in antigens, if someone receives incompatible blood from a donor, for example, the recipient's immune system may detect those antigens as foreign and react against them. This can be highly dangerous, and is why donated blood needs to be a suitable match if someone is having a transfusion. On average, one new blood classification system has been described by researchers each year during the past decade. These newer systems tend to involve blood types that are mind-bogglingly rare but, for those touched by them, just knowing that they have such blood could be lifesaving. This is the story of how scientists unraveled the mystery of the latest blood system -- and why it matters.

Ars Technica's Eric Berger writes: Four days before Thanksgiving in 2002, space shuttle Endeavour lifted off from Kennedy Space Center in Florida. Among the seven crew members to the International Space Station was one Russian cosmonaut, Nikolai M. Budarin, making his third spaceflight. By then, as part of warming relations between Russia and the United States, cosmonauts had been flying on board the space shuttle for nearly a decade. The exchange program would have continued, but tragedy struck on the shuttle's next mission, which launched in January 2003. Space Shuttle Columbia was lost upon reentry into Earth's atmosphere, killing all seven astronauts on board.

Following this disaster, no more Russians would fly on the space shuttle after it returned to service. Instead, NASA focused on flying the minimum number of missions needed to complete the construction of the International Space Station. After the shuttle's retirement in 2011, NASA would come to rely on Russia's Soyuz vehicle as its only ride to space. NASA regained the capacity to launch its own astronauts into space in 2020, after working with SpaceX to complete the development of the Crew Dragon vehicle. Following a successful demonstration flight in May 2020 with two astronauts on board, Crew Dragon safely launched six additional times, carrying an additional two dozen people into space.

On Wednesday, Crew Dragon carried astronauts into space for an eighth time, with the fifth operational mission for NASA. This Crew-5 flight was commanded by Nicole Mann, a NASA astronaut making her first flight into space. "Whooo, that was a smooth ride uphill!" she exclaimed upon reaching orbit. Among the four Dragon riders was a cosmonaut, Anna Kikina, also making her debut flight into space. She is just the sixth Russian or Soviet female cosmonaut in the history of the program since Valentina Tereshkova flew into orbit on June 16, 1963. Kikina is also the first Russian to launch into space from the United States since Budarin, two decades ago. In addition to Mann and Kikina, Crew-5 is rounded out by NASA astronaut Josh Cassada and Japanese astronaut Koichi Wakata. While the other three are rookies, this is Wakata's fifth spaceflight. During their stay aboard the International Space Station, the astronauts will conduct more than 200 science experiments and technology demonstrations, including studies on printing human organs in space.

The Nobel Prize in Chemistry was awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless on Wednesday for the development of click chemistry and bio-orthogonal chemistry -- work that has "led to a revolution in how chemists think about linking molecules together," the Nobel committee said. The New York Times: Dr. Bertozzi is the eighth woman to be awarded the prize, and Dr. Sharpless is the fifth scientist to be honored with two Nobels, the committee noted. Johan Aqvist, the chair of the chemistry committee, said that this year's prize dealt with "not overcomplicating matters, instead working with what is easy and simple."

"Click chemistry is almost like it sounds," he said of a field whose name Dr. Sharpless coined in 2000. "It's all about snapping molecules together. Imagine that you could attach small chemical buckles to different types of building blocks. Then you could link these buckles together and produce molecules of greater complexity and variation." Shortly after Dr. Sharpless coined the concept, both he and Dr. Meldal independently discovered a chemical reaction called copper-catalyzed azide-alkyne cycloaddition, known today as the crown jewel of click chemistry. "When this reaction was discovered, it was like opening the floodgates," Olof Ramstrom, a member of the Nobel Committee for Chemistry, said in a briefing after the laureates were announced. "We were using it everywhere, to build everything." Dr. Bertozzi, a chemist and professor at Stanford, was able to apply this reaction to biomolecules, often found on cell surfaces, in living organisms without affecting the chemistry of the cells she was observing. Before her extensive research with glycans, or sugar chains, scientists' understanding of this subfield of glycobiology had been hampered by an inability to see molecules in action in living cells.

Enzymes that rapidly break down plastic bags have been discovered in the saliva of wax worms, which are moth larvae that infest beehives. From a report: The enzymes are the first reported to break down polyethylene within hours at room temperature and could lead to cost-effective ways of recycling the plastic. The discovery came after one scientist, an amateur beekeeper, cleaned out an infested hive and found the larvae started eating holes in a plastic refuse bag. The researchers said the study showed insect saliva may be "a depository of degrading enzymes which could revolutionise [the cleanup of polluting waste]."

Polyethylene makes up 30% of all plastic production and is used in bags and other packaging that make up a significant part of worldwide plastic pollution. The only recycling at scale today uses mechanical processes and creates lower-value products. Chemical breakdown could create valuable chemicals or, with some further processing, new plastic, thereby avoiding the need for new virgin plastic made from oil. The enzymes can be easily synthesised and overcome a bottleneck in plastic degradation, the researchers said, which is the initial breaking of the polymer chains. That usually requires a lot of heating, but the enzymes work at normal temperatures, in water and at neutral pH.

Drinking two to three cups of coffee a day could be linked to a longer lifespan, new research suggests. When compared with avoiding coffee, it was also associated with a lower risk of cardiovascular disease, the study found. From a report: The findings applied to ground, instant and decaffeinated varieties of the drink, and researchers say they suggest coffee consumption should be considered part of a healthy lifestyle. According to the study, the greatest risk reduction was seen with two to three cups per day. Compared with no coffee drinking, this was associated with a 14%, 27% and 11% lower likelihood of death for decaffeinated, ground and instant preparations, respectively. Study author Professor Peter Kistler of the Baker Heart and Diabetes Research Institute, Australia, said: "In this large, observational study ground, instant and decaffeinated coffee were associated with equivalent reductions in the incidence of cardiovascular disease and death from cardiovascular disease or any cause. "The results suggest that mild to moderate intake of ground, instant and decaffeinated coffee should be considered part of a healthy lifestyle." The study examined the links between types of coffee and heart rhythms, cardiovascular disease and death using data from the UK Biobank study, which recruited adults between 40 and 69 years of age. Cardiovascular disease was made up of coronary heart disease, congestive heart failure and ischaemic stroke.

The Nobel Prize in Physics was awarded to Alain Aspect, John F. Clauser and Anton Zeilinger on Tuesday for work that has "laid the foundation for a new era of quantum technology," the Nobel Committee for Physics said. The scientists have each conducted "groundbreaking experiments using entangled quantum states, where two particles behave like a single unit even when they are separated," the committee said in a briefing. From a report: Their results, it said, cleared the way for "new technology based upon quantum information." The laureates' research builds on the work of John Stewart Bell, a physicist who strove in the 1960s to understand whether particles, having flown too far apart for there to be normal communication between them, can still function in concert, also known as quantum entanglement.

According to quantum mechanics, particles can exist simultaneously in two or more places. They do not take on formal properties until they are measured or observed in some way. By taking measurements of one particle, like its position or "spin," a change is observed in its partner, no matter how far away it has traveled from its pair. Working independently, the three laureates did experiments that helped clarify a fundamental claim about quantum entanglement, which concerns the behavior of tiny particles, like electrons, that interacted in the past and then moved apart. Dr. Clauser, an American, was the first in 1972. Using duct tape and spare parts at Lawrence Berkeley National Laboratory in Berkeley, Calif., he endeavored to measure quantum entanglement by firing thousands of photons in opposite directions to investigate a property known as polarization. When he measured the polarizations of photon pairs, they showed a correlation, proving that a principle called Bell's inequality had been violated and that the photon pairs were entangled, or acting in concert.

The research was taken up 10 years later by Dr. Aspect, a French scientist, and his team at the University of Paris. And in 1998, Dr. Zeilinger, an Austrian physicist, led another experiment that considered entanglement among three or more particles. Eva Olsson, a member of the Nobel Committee for Physics, noted that quantum information science had broad implications in areas like secure information transfer and quantum computing. Quantum information science is a "vibrant and rapidly developing field," she said. "Its predictions have opened doors to another world, and it has also shaken the very foundation of how we interpret measurements." The Nobel committee said the three scientists were being honored for their experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum information science.

Local newspaper Mint reports: The Indian Space Research Organisation on 3 October confirmed that the Mars Orbiter craft has lost communication with ground station, it's non-recoverable and with this the Mangalyaan mission has attained end-of-life. Giving an update on the Mars Orbiter Mission (MOM), ISRO was celebrating the completion of its eight years in the Martian orbit and commemorate MOM. Despite being designed for a life-span of six months as a technology demonstrator, the MOM lived for about eight years in the Martian orbit with a gamut of significant scientific results on Mars as well as on the Solar corona.

Though it has lost communication with the ground station, due to a long eclipse in April 2022, ISRO said. ISRO deliberated that the propellant must have been exhausted, and therefore, the "desired altitude pointing" could not be achieved for sustained power generation. "It was declared that the spacecraft is non-recoverable, and attained its end-of-life", an ISRO statement said, adding, "The mission will be ever-regarded as a remarkable technological and scientific feat in the history of planetary exploration."

The Nobel Prize in Physiology or Medicine was awarded to Svante Paabo on Monday for his discoveries concerning the genomes of extinct hominins and human evolution. From a report: It was the first of several prizes to be given over the next week. The Nobel Prizes, among the highest honors in science, recognize groundbreaking contributions in a variety of fields. "Through his pioneering research, Svante Paabo -- this year's Nobel Prize laureate in physiology or medicine -- accomplished something seemingly impossible: sequencing the genome of the Neanderthal, an extinct relative of present-day humans," the Nobel committee said in a statement. "Paabo's discoveries have generated new understanding of our evolutionary history," the statement said, adding that this research had helped establish the burgeoning science of "paleogenomics," or the study of genetic material from ancient pathogens.

Nils-Goran Larsson, a professor in medical biochemistry for the Karolinska Institute in Stockholm, said that Dr. Paabo had used existing technology and his own methods to extract and analyze the ancient DNA. "It was certainly considered to be impossible to recover DNA from 40,000-year-old bones," Dr. Larsson said, adding later that the discoveries would "allow us to compare changes between contemporary Homo sapiens and ancient hominins. And this, over the years to come, will give us huge insights into human physiology."

The first map of the "galactic underworld" -- a chart of the corpses of once massive suns that have since collapsed into black holes and neutron stars -- has revealed a graveyard that stretches three times the height of the Milky Way, and that almost a third of the objects have been flung out from the galaxy altogether. Phys.Org reports: "These compact remnants of dead stars show a fundamentally different distribution and structure to the visible galaxy," said David Sweeney, a Ph.D. student at the Sydney Institute for Astronomy at the University of Sydney, and lead author of the paper in the latest issue of Monthly Notices of the Royal Astronomical Society. "The 'height' of the galactic underworld is over three times larger in the Milky Way itself," he added. "And an amazing 30 percent of objects have been completely ejected from the galaxy." [...] Sweeney added that "the hardest problem I had to solve in hunting down their true distribution was to account for the 'kicks' they receive in the violent moments of their creation. Supernova explosions are asymmetric, and the remnants are ejected at high speed -- up to millions of kilometers per hour -- and, even worse, this happens in an unknown and random direction for every object." But nothing in the universe sits still for long, so even knowing the likely magnitudes of the explosive kicks was not enough: the researchers had to delve into the depths of cosmic time and reconstruct how they behaved over billions of years.

The intricate models they built -- together with University of Sydney Research Fellow Dr. Sanjib Sharma and Dr. Ryosuke Hirai of Monash University -- encoded where the stars were born, where they met their fiery end and their eventual dispersal as the galaxy evolved. The final outcome is a distribution map of the Milky Way's stellar necropolis.

In the maps generated, the characteristic spiral arms of the Milky Way vanish in the 'galactic underworld' version. These are entirely washed out because of the age of most of the remnants, and the blurring effects of the energetic kicks from the supernovae which created them. Even more intriguing, the side-on view shows that the galactic underworld is much more 'puffed up' than the Milky Way -- a result of kinetic energy injected by supernovae elevating them into a halo around the visible Milky Way. "One of the problems for finding these ancient objects is that, until now, we had no idea where to look," said Sydney Institute for Astronomy's Professor Peter Tuthill, co-author on the paper. "The oldest neutron stars and black holes were created when the galaxy was younger and shaped differently, and then subjected to complex changes spanning billions of years. It has been a major task to model all of this to find them."

"It's a little like in snooker," said Sweeney. "If you know which direction the ball is hit, and how hard, then you can work out where it will end up. But in space, the objects and speeds are just vastly bigger. Plus, the table's not flat, so the stellar remnants go on complex orbits threading through the galaxy." He added: "Finally, unlike a snooker table, there is no friction -- so they never slow down. Almost all the remnants ever formed are still out there, sliding like ghosts through interstellar space."

NASA says the damage to their launch facilities in Florida following Hurricane Ian was minimal and work was already underway for a "rapid-fire succession of three launches in three days," reports Ars Technica. An anonymous reader shares an excerpt from the report: First up is a commercial mission on United Launch Alliance's Atlas V rocket to launch SES-20 and SES-21 satellites for Luxembourg-based satellite operator SES. Stacked in its '531' configuration, this Atlas rocket has a five-meter-diameter payload fairing, three solid rocket boosters, and one engine on the upper-stage Centaur. On Friday, United Launch Alliance said everything continues to progress toward the launch of this mission on Tuesday, October 4, from Space Launch Complex-41 at Cape Canaveral Space Force Station. The launch is planned for 5:36 pm EST (21:36 UTC). Weather is forecast to be favorable, with a 70 percent chance of favorable conditions for launch. After launching, the Atlas V rocket will deliver the pair of communications satellites into near-circular, near-geosynchronous orbits. Once separated, the satellites will use onboard propulsion systems to circularize their orbits at 35,900 km above the equator.

Next up in Florida is NASA's Crew-5 mission, which will launch on a Falcon 9 rocket to the International Space Station. NASA officials confirmed this mission remains on schedule for noon EST (16:00 UTC) on October 5 from Launch Complex-39A at Kennedy Space Center. The crew of four -- NASA astronauts Nicole Mann and Josh Cassada, Japan Aerospace Exploration Agency astronaut Koichi Wakata, and Roscosmos cosmonaut Anna Kikina -- have been holding at Johnson Space Center in Houston pending the outcome of Hurricane Ian. However, they will now fly to Florida on Saturday in preparation for the launch. SpaceX, meanwhile, will roll its Falcon 9 rocket with the Crew Dragon spacecraft to the launchpad on Friday night or Saturday, ahead of a static fire test on Sunday. There appear to be no significant technical issues to be worked on ahead of the launch next Wednesday.

Finally, on October 6, SpaceX plans an additional launch. For this mission, from Space Launch Complex-40 at Cape Canaveral, a Falcon 9 rocket will deliver Intelsat's Galaxy 33 and 34 satellites telecommunications satellites into a geostationary transfer orbit. The launch is set for 7:07 pm EST (23:07 UTC). Of note for this mission, this Falcon 9 first-stage booster will be making its 14th launch. This marks the first time a SpaceX rocket has flown a purely commercial payload on its 10th flight or later. This strongly suggests that the commercial satellite market is becoming increasingly comfortable with SpaceX's refurbishment process for even well-used rockets. Additionally, NASA said that its Artemis I hardware "survived Hurricane Ian just fine, safely tucked inside the large Vehicle Assembly Building at Kennedy Space Center," notes Ars. "The agency will aim to have the rocket ready for a launch attempt in about six weeks."

"Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks. The study was recently published in the journal Nature. UC San Francisco reports: The compounds were designed to fit into the 5HT2a receptor, which is the main target of psychedelics like LSD and psilocybin mushrooms. The receptor is also activated by serotonin, a naturally occurring hormone that regulates mood, cognition and many other functions in the body. The 5HT2a receptor is thought to play a role in schizophrenia and other psychotic disorders, as well as anxiety and depression, and a host of antipsychotic and antidepressant drugs block its activity. The new molecules activate it, but in a very different way than psychedelics.

[...] Although it's been known for several decades that 5HT2a receptors activate different signaling pathways in cells, until now there were no compounds selective enough to see what each pathway did. The scientific team discovered the receptors could set off two different pathways, a hallucinatory pathway and an antidepressant/antianxiety one. LSD activates the first one more, while the new compounds activate the second one more. "The receptors are like antennae," said Brian Shoichet, PhD, professor of pharmaceutical chemistry in the UCSF School of Pharmacy. "They pick up a chemical signal, and downstream a bunch of things get activated in a cell."

The compounds had been selected from a computational library of 75 million candidates. Jonathan Ellman, PhD, the Eugene Higgins Professor of Chemistry, and professor of pharmacology at Yale, synthesized them. And the UCSF, UNC, Yale team worked for more than a year to optimize them. "The final molecules were 100 times more potent than what we started with," Shoichet said, although they were still not nearly as strong as LSD. "In the animals they are very potent, much more potent than Prozac." The team expanded to test the designer molecules in mice, adding William Wetsel, PhD, who directs the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke. His lab looked for head twitch responses that are the tell-tale signs of psychedelic activity in mice. But the mice hardly twitched. Wetsel's lab ran the mice through a battery of tests to see if the molecules could ameliorate symptoms analogous to human anxiety and depression. And they were highly effective. After many years, what had begun as a science experiment arrived at a discovery with great clinical promise. "The team's next project will be optimizing the compounds, making them selective enough to be used in clinical trials," adds the report.

"A key issue will be making molecules that have no affinity for 5HT2b. Drugs that hit this receptor, like the banned diet drug fen-phen, can cause valvular heart disease when taken chronically. That receptor is also hit by psychedelics, particularly LSD."