pigrabbitbear writes with musings on the anniversary of the groundbreaking paper on DNA structure by Watson and Crick. From the article: "Consider every organism that's ever lived on Earth. From dinosaurs to bacteria, the number is near infinite, and an overwhelming majority have their entire structures and lives dictated according to their DNA. The DNA molecule is life itself, and it's astonishing that we've only known what it looks like for less than a century. But it's true: In one of the most groundbreaking papers ever published, James D. Watson and Francis Crick described the double-helix structure of DNA in Nature, 59 years ago today."

New submitter AcMNPV writes "A news release from UCLA describes a new process for producing biofuels using microorganisms, electrical current and carbon dioxide (abstract). Quoting: 'Liao and his team genetically engineered a lithoautotrophic microorganism known as Ralstonia eutropha H16 to produce isobutanol and 3-methyl-1-butanol in an electro-bioreactor using carbon dioxide as the sole carbon source and electricity as the sole energy input. Photosynthesis is the process of converting light energy to chemical energy and storing it in the bonds of sugar. There are two parts to photosynthesis — a light reaction and a dark reaction. The light reaction converts light energy to chemical energy and must take place in the light. The dark reaction, which converts CO2 to sugar, doesn't directly need light to occur. "We've been able to separate the light reaction from the dark reaction and instead of using biological photosynthesis, we are using solar panels to convert the sunlight to electrical energy, then to a chemical intermediate, and using that to power carbon dioxide fixation to produce the fuel," Liao said.'"

gambit3 writes "My wife and I are expecting our first child in 3 months, and one of the decisions we still have to make is whether to store our baby's cord blood. Even if we decide the upfront cost is worth it, there is still the question of using a public bank or a private one (and which one to trust), and whether to also store umbilical cord tissue for stem cells. Does you have any experience or suggestions?"

cylonlover writes "In an effort to provide a more accurate alternative to conventional cell culture and animal models, researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have developed a microdevice that mimics the structure, physiology, and mechanics of the human intestine. The so-called 'gut-on-a-chip' could help provide new insights into intestinal disorders and be used to evaluate the safety and efficacy of potential treatments."

An anonymous reader writes "According to new study published in Nature (abstract), MIT researchers have figured out how to trigger specific memories in rats by hitting certain neurons with a pulse of light. From the article: 'The researchers first identified a specific set of brain cells in the hippocampus that were active only when a mouse was learning about a new environment. They determined which genes were activated in those cells, and coupled them with the gene for channelrhodopsin-2 (ChR2), a light-activated protein used in optogenetics. ... The light-activated protein would only be expressed in the neurons involved in experiential learning — an ingenious way to allow for labeling of the physical network of neurons associated with a specific memory engram for a specific experience. Finally, the mice entered an environment and, after a few minutes of exploration, received a mild foot shock, learning to fear the particular environment in which the shock occurred. The brain cells activated during this fear conditioning became tagged with ChR2. Later, when exposed to triggering pulses of light in a completely different environment, the neurons involved in the fear memory switched on — and the mice quickly entered a defensive, immobile crouch.'"

cylonlover writes "Because everyone's immune system is different, it's impossible to predict with absolute certainty how any given person will react to a specific medication. In the not-too-distant future, however, at-risk patients may get their own custom-altered mouse, with an immune system that's a copy of their own. Medications could be tried out on the mouse first, and if they are shown to have no adverse effects, the person could take the medication with a higher degree of confidence. If the person has an autoimmune disease, the mouse could also provide valuable insight into its treatment. A team led by Columbia University Medical Center's Dr. Megan Sykes has recently developed a method of creating just such a 'personalized immune mouse.'"

sciencehabit writes "Michael Snyder has taken 'know thyself' to the next level. Over a 14-month period, the molecular geneticist analyzed his blood 20 different times to pluck out a wide variety of biochemical data depicting the status of his body's immune system, metabolism, and gene activity. In yesterday's issue of Cell (abstract), Snyder and a team of 40 other researchers present the results of this extraordinarily detailed look at his body, which they call an integrative personal omics profile (iPOP) because it combines cutting-edge scientific fields such as genomics (study of one's DNA), metabolomics (study of metabolism), and proteomics (study of proteins). Instead of seeing a snapshot of the body taken during the typical visit to a doctor's office, iPOP effectively offers an IMAX movie, which in Snyder's case had the added drama of charting his response to two viral infections and the emergence of type 2 diabetes."

An anonymous reader writes "Last year Russian researchers discovered a well-preserved mammoth thigh bone and announced plans to clone a mammoth from the bone marrow within — and they just signed a deal with South Korea's Sooam Biotech Research Foundation to bring the project to fruition. The Sooam scientists plan to implant the nucleus of a woolly mammoth cell into an elephant egg in order to to create a mammoth embryo, which would then be placed in an elephant womb. 'This will be a really tough job,' Soaam reasearcher Hwang In-Sung said, 'but we believe it is possible because our institute is good at cloning animals.'" Not to be confused with a similar mammoth effort at mammoth-cloning at Kyoto University.

New submitter greatgreygreengreasy writes "According to NPR, 'Lawmakers in New York approved a bill that will make the state the first to require DNA samples from almost all convicted criminals. Most states, including New York, already collect DNA samples from felons, according to the National Conference of State Legislatures. What's remarkable about the New York bill is that it would expand the state's database to include DNA from people convicted of almost any crime, even misdemeanors as minor as jumping over a subway turnstile.' Gattaca seems closer than we may have thought. Richard Aborn, one of the bill's backers, said, 'We know from lots of studies and lots of data now that violent criminals very often begin their careers as nonviolent criminals. And the earlier you can get a nonviolent criminal's DNA in the data bank, the higher your chances are of apprehending the right person.'"

First time accepted submitter eternaldoctorwho writes "Research has been underway to produce a coffee bean plant that naturally has no or little caffeine content. Now, it looks like that might become a reality in the near future: Paulo Mazzafera of the University of Campinas in Brazil has come closer than ever with a strain containing 'only 2% of normal caffeine levels.' Coffee, anyone?"

ananyo writes "In another victory for crowdsourcing, gamers playing Phylo have beaten a state-of-the-art program at aligning regions of 521 disease-associated genes form different species. The 'multiple sequence alignment problem' refers to the difficulty of aligning roughly similar sequences of DNA in genes common to many species. DNA sequences that are conserved across species may play an important role in the ultimate function of that particular gene. But with thousands of genomes likely to be sequenced in the next few years, sequence alignment will only become more difficult in future. Researchers now report that players of Phylo have produced roughly 350,000 solutions to various multiple sequence alignment problems, beating the accuracy of alignments from a program in roughly 70% of the sequences they manipulated."

derekmead writes "Forget CFLs, hybrid cars, and organic jeans. Buying our way out of climate change — even if it's green consumption — won't get us far. A new paper (PDF), published in Ethics, Policy, and the Environment by NYU bioethics professor S. Matthew Liao, poses an answer: engineer humans to use less. The general plan laid out by Liao is straightforward, ranging from using pharmacological behavior modification to create an aversion to meat in people, to using gene therapy to create smaller, less resource-intensive children. The philosophical and ethical questions, on the other hand, are absurdly complicated. The Atlantic also has a great interview with Liao, in which he talks about gene therapy and making humans hate the taste of meat."

An anonymous reader sends this excerpt from MIT's Technology Review: "A new blob-like robot described in the journal Advanced Robotics uses springs, feet, 'protoplasm' and a distributed nervous system to move in a manner inspired by the slime mold Physarum polycepharum. ... Researcher Takuya Umedachi of Hiroshima University has been perfecting his blob-bot for years, starting with early prototypes that used springs but lacked an air-filled bladder. ... Umedachi modeled his latest version on the 'true' slime mold, which has been shown to achieve a 'human-like' decision-making capacity through properties emerging from the interactions of its individual spores (abstract). Slime molds appear to have general computational abilities, and you've probably heard that they can solve mazes."

New submitter Guppy writes "A previous story reported widely in the media, and appearing both on Slashdot and XKCD, described a novel cancer treatment, in which a patient's own T-cells were modified using an HIV-derived vector to recognize and kill leukemia cells. In a follow-up publication (PDF), a further development is described which allows for a nearly unlimited choice of target antigens, broadening the types of malignancies potentially treatable with the technique (abstract)."

LilaG writes "Not just a way to transport trains at high speed, magnetic levitation could find use in diagnosing disease. Researchers at Harvard have shown that they can detect proteins in blood using MagLev. The researchers, led by George Whitesides, use levitation to detect a change in the density of porous gel beads that occurs when a protein binds to ligands inside the beads. The lower the bead levitates, the more protein it holds. The method (abstract of paywalled article) could work for detecting disease proteins in people's blood samples in the developing world: The magnets cost only about $5 each, and the device requires no electricity or batteries. Because the beads are visible to the naked eye, researchers can make measurements with a simple ruler with a millimeter scale."

ananyo writes "Bioethicist Glenn McGee has resigned his position as president of ethics and strategic initiatives at the stem-cell firm Celltex Therapeutics in Houston, Texas. Yesterday, Slashdot posted a story that suggested Celltex may have administered unproven treatments to several patients. The move comes at the end of a turbulent three months, which has seen McGee blasted by other bioethicists for working at the controversial stem-cell company while also holding the post of editor-in-chief of the American Journal of Bioethics, the most cited bioethics journal in the world. McGee announced that he had resigned, effective 28 February, on Twitter last night — the move came just two weeks after the 13 February press release by Celltex announcing that he would take the position."

cylonlover writes "A strong and highly selective instant adhesive inspired by the bacterium Streptococcus pyogenes has been developed by Oxford University researchers. S. pyogenes is a common resident of human throats that is normally kept in check by the body's defenses, but when it gets out of control it can cause diseases ranging from strep throat to toxic shock syndrome or flesh-eating disease. By engineering a protein that is central to S. pyogenes' infectious arsenal, the researchers have developed a new superglue that can't be matched for sticking molecules together and not letting go."

ananyo writes "With Texas pouring millions of dollars into developing adult stem-cell treatments, doctors there are already injecting paying customers with unproven preparations, supplied by an ambitious new company. Celltex Therapeutics 'multiplies and banks' stem cells derived from people's abdominal fat and its facility in Sugar Land opened in December 2011 and houses the largest stem-cell bank in the United States. But Nature has uncovered evidence that the company is involved in the clinical use of the cells on US soil, which the FDA has viewed as illegal in other cases."

An anonymous reader writes "Researchers from The University of Nottingham have demonstrated how a species of flatworm overcomes the aging process to be potentially immortal. The discovery, published (abstract; full text PDF) in the Proceedings of the National Academy of Sciences, is part of a project funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council and may shed light on the possibilities of alleviating aging and age-related characteristics in human cells." After finding the gene for telomerase synthesis in the worms, the researchers were able to observe that the worms "...dramatically increase the activity of this gene when they regenerate, allowing stem cells to maintain their telomeres as they divide to replace missing tissues."

sciencehabit writes "Men typically produce working sperm as long as they live, but most textbooks say female mammals are born with all the egg cells, or oocytes, they will ever have. Since 2004, however, reproductive biologist Jonathan Tilly of Massachusetts General Hospital in Boston has challenged that conventional wisdom, arguing that in mice—and perhaps also in humans—there must be an ongoing source of new eggs. Today, Tilly and his colleagues report isolating rare cells in ovarian tissue from adult women that can grow in lab dishes and form immature oocytes. The potential egg stem cells could help scientists devise new ways to help rescue the fertility of women who have to undergo cancer treatments or who suffer from premature menopause."