sciencehabit writes "Whooping cough, or pertussis, has exploded in the United States in recent years. A new study (abstract) confirms what scientists have suspected for some time: The return of the disease is caused by the introduction of new, safer vaccines 2 decades ago. Although they have far fewer side effects, the new shots don't offer long-lived protection the way older vaccines do."

sciencehabit writes "If you are one of the 20% of healthy adults who struggle with basic arithmetic, simple tasks like splitting the dinner bill can be excruciating. Now, a new study suggests that a gentle, painless electrical current applied to the brain can boost math performance for up to 6 months. Researchers don't fully understand how it works, however, and there could be side effects." We've covered various other potential benefits to having your brain shocked.

jfruh writes "Larry Page revealed that he'd been suffering from a vocal cord ailment that impaired his ability to speak for more than a year. The positive feedback he got from opening up about it inspired him to tell attendees at Google I/O that we should all be less uptight about keeping our medical records private. As far as Page is concerned, pretty much the only legitimate reason for worry on this score is fear of being denied health insurance. 'Maybe we should change the rules around insurance so that they have to insure people,' he said."

theodp writes "Last summer, unspecified voice problems caused Google CEO Larry Page to miss Google's Annual Shareholder Meeting, the I/O conference, and a quarterly earnings call. Now, Page has come forward and revealed that he suffers from partial paralysis of each of his vocal chords, an 'extremely rare' condition. Not unlike what Sergey Brin and his wife are doing with Parkinson's research, Page and his wife will be funding and overseeing 'a significant research program' led by Dr. Steven Zeitels of Harvard Medical School."

symbolset writes "Research published yesterday in the journal Cell (abstract) by Richard Lee and Amy Wagers of Harvard has isolated GDF-11 as a negative regulator of age-associated cardiac hypertrophy. 'When the protein ... was injected into old mice, which develop thickened heart walls in a manner similar to aging humans, the hearts were reduced in size and thickness, resembling the healthy hearts of younger mice.' Through a type of transfusion called parabiotic or 'shared circulation' in mice — one old and sick, the other young and well — they managed to reverse this age-associated heart disease. From there, they isolated an active agent, GDF-11, present in the younger mouse but absent in the older, which reverses the condition when administered directly. They are also using the agent to restore other aged/diseased tissues and organs. Human applications are expected within six years. Since the basis for the treatment is ordinary sharing of blood between an older ill, and younger healthy patient, we can probably expect someone to start offering the transfusion treatment somewhere in the world, soon, to those with the means to find a young and healthy volunteer."

DavidHumus writes "A recent study indicates that consuming vegetables from the Solanaceae family, which includes tomatoes and peppers (as well as tobacco), decreases the risk of contracting Parkinson's disease. Earlier studies had shown that smoking tobacco seems to provide protection against the disease and the newer one seems to confirm that the key ingredient is nicotine, which is present in some vegetables like peppers."

Arglebarf writes "A family member is recovering from a serious illness and, unfortunately, the medication that saved her life will probably cost her hands and feet. She is an artist by trade, so this is a pretty big deal. Replacement prostheses might restore a degree of independence, as well as enabling her to continue with her creative passions. Do any Slashdotters have experience with replacement hands? What features do you look for? Do any models allow you tweak the software for fine tuning? Beyond the day-to-day uses, she will want something that can hold small objects precisely (e.g. a paintbrush)."

New submitter Big Nemo '60 writes with news that the National Institute of Mental Health is seeking to modernize the diagnosis of mental illness through the use of neuroscience, genetics, etc. From the article: "The world's biggest mental health research institute is abandoning the new version of psychiatry's 'bible' — the Diagnostic and Statistical Manual of Mental Disorders — questioning its validity and stating that 'patients with mental disorders deserve better.' This bombshell comes just weeks before the publication of the fifth revision of the manual, called DSM-5." More importantly, they are going to be shifting funding to research projects that seek to define new categories of mental illness using modern medical science, ignoring the current DSM categorizations: "The strength of each of the editions of DSM has been 'reliability' .. The weakness is its lack of validity. Unlike our definitions of ischemic heart disease, lymphoma, or AIDS, the DSM diagnoses are based on a consensus about clusters of clinical symptoms, not any objective laboratory measure. In the rest of medicine, this would be equivalent to creating diagnostic systems based on the nature of chest pain or the quality of fever. ... NIMH has launched the Research Domain Criteria (RDoC) project to transform diagnosis by incorporating genetics, imaging, cognitive science, and other levels of information to lay the foundation for a new classification system. ... It became immediately clear that we cannot design a system based on biomarkers or cognitive performance because we lack the data. In this sense, RDoC is a framework for collecting the data needed for a new nosology. But it is critical to realize that we cannot succeed if we use DSM categories as the 'gold standard.' ... Imagine deciding that EKGs were not useful because many patients with chest pain did not have EKG changes. That is what we have been doing for decades when we reject a biomarker because it does not detect a DSM category. We need to begin collecting the genetic, imaging, physiologic, and cognitive data to see how all the data — not just the symptoms — cluster and how these clusters relate to treatment response."

Zothecula writes "Instead of traipsing through Florida in search of the Fountain of Youth, Spanish explorer Juan Ponce de León might have been better off turning his search inwards. More specifically, he should have turned his attention to a region of the brain called the hypothalamus. At least that's what research carried out on mice by scientists at New York's Albert Einstein College of Medicine of Yeshiva University suggests. They found that the hypothalamus controls many aspects of aging, opening up the potential to slow down the aging process by altering signal pathways within that part of the brain."

Guppy writes "Does Tylenol reduce existential distress? Acetaminophen (Paracetamol) has been used to relieve mild-to-moderate physical pain for over a century, yet its actual mechanism of action continues to be debated; modern research has demonstrated an intriguing connection with the body's endocannabinoid system, raising the question of whether it may also have subtle psychological effects as well. A recent paper claims Acetaminophen can alter our response to existential challenge; previous findings have suggested that it may blunt the pain of social rejection as well."

Hatta writes "According to researchers from Harvard Medical School, belief in god is correlated with improved outcomes of treatment for depression. Quoting: 'In the study, published in the current issue of Journal of Affective Disorders, researchers comment that people with a moderate to high level of belief in a higher power do significantly better in short-term psychiatric treatment than those without. "Belief was associated with not only improved psychological well-being, but decreases in depression and intention to self-harm," says David H. Rosmarin, Ph.D., an instructor in the Department of Psychiatry at Harvard Medical School.' This raises interesting questions. Does this support the concept of depressive realism? If the association is found to be causal, would it be ethical for a psychiatrist to prescribe religion?"

An anonymous reader writes "Back in the '60s, Bell Labs created a 'paper computer' called CARDIAC so students could learn the fundamentals of computers. Dr. Dobb's recreates the paper computer in an Excel spreadsheet and hints they will show how it gets ported to an FPGA in future installments."

sciencehabit writes "Citing an increasingly bleak outlook for federal research funding, Harvard Medical School is shutting down its major primate center, which has recently experienced the departure of several key scientists and an investigation into its handling of animals. In the announcement, which surprised many primate researchers, the school said it will not seek to renew the New England Primate Research Center's (NEPRC's) 5-year grant from the National Institutes of Health (NIH) and will 'wind down operations' at the center in Southborough, Massachusetts, over the next 2 years. The center, which has a nearly 50-year history, had done groundbreaking work on an AIDS vaccine and developed animal models for diseases such as Parkinson's, among other accomplishments."

kkleiner writes "A new device will keep a liver alive outside of the human body for up to 24 hours. Developed at Oxford, the OrganOx circulates oxygenated red bloods cells and nutrients through the liver while maintaining the proper temperature. Doctors estimate that this new technique could double the number of livers available, saving the lives of thousands who die every year awaiting transplant."

ananyo writes "Two dangerous things together might make a medicine for one of the hardest cancers to treat. In a mouse model of pancreatic cancer, researchers have shown that bacteria can deliver deadly radiation to tumours — exploiting the immune suppression that normally makes the disease so intractable. The researchers coated the bacterium Listeria monocytogenes with radioactive antibodies and injected the bacterium into mice with pancreatic cancer that had spread to multiple sites. After several doses, the mice that had received the radioactive bacteria had 90% fewer metastases compared with mice that had received saline or radiation alone."

First time accepted submitter ckwu writes "Scientists once thought that pathogens could not reach drinking water wells sunk into deep, protected groundwater aquifers. Nevertheless, over the past decade, researchers have identified diarrhea-causing viruses at a handful of deep bedrock well sites in the U.S. and Europe. Now, researchers report where these pathogenic viruses may have originated. The viruses appear to seep from sewer pipes and then swiftly penetrate drinking water wells. Experts recommend that public water systems might need to start testing for viruses on a routine basis."

ananyo writes "Activists occupied an animal facility at the University of Milan, Italy, at the weekend, releasing mice and rabbits and mixing up cage labels to confuse experimental protocols. Researchers at the university say that it will take years to recover their work. Many of the animals at the facility are genetic models for psychiatric disorders such as autism and schizophrenia. Some of the mice removed by activists were delicate mutants and immunosuppressed 'nude' mice, which die very quickly outside controlled environments. No arrests have been made following the 12-hour drama, which took place on Saturday, although the university says that it will press charges against the protesters. The attack was staged by the animal-rights group that calls itself Fermare Green Hill (or Stop Green Hill), in reference to the Green Hill dog-breeding facility near Brescia, Italy, which it targets for closure."

colinneagle writes "During a recent trip to an eye doctor, I noticed that she was still using Windows XP. After I suggested that she might need to upgrade soon, she said she couldn't because she couldn't afford the $10,000 fee involved with the specialty medical software that has been upgraded for Windows 7. Software written for medical professionals is not like mass market software. They have a limited market and can't make back their money in volume because there isn't the volume for an eye doctor's database product like there is for Office or Quicken. With many expecting Microsoft's upcoming end-of-support for XP to cause a security nightmare of unsupported Windows devices in the wild, it seems a good time to ask how many users may fall into the category of wanting an upgrade, but being priced out by expensive but necessary third-party software. More importantly, can anything be done about it?"

Knowledge Ecology International (KEI) director Jamie Love -- formally James Packard Love -- is the brain behind the "$1 a day" HIV drugs that have saved millions of lives in Africa and other poor parts of the world. Basically, he went around asking, "How much would it cost to make this HIV medication if the patent cost was removed?" At first, no one could answer. After a while, the answer came: Less than $1 a day. At that price, the Bush administration set up a massive program to deliver generic anti-HIV drugs to Africa. Jamie also works on copyright issues, boosts free software (he's a Linux user/evangelist and had more than a little to do with the Microsoft antitrust suit), and generally tries to make the international knowledge ecology more accessible and more useful for everyone, especially those who aren't rich. Or necessarily even prosperous. He's a smart guy (read the Wikipedia entry linked above), but more than that he's bullheaded. Jamie has worked on some of his initiatives for years, even decades. In many cases you can't say, "He hasn't succeeded," without adding "yet" on the end. (You'll understand that statement better after you watch the video, which we broke into two parts because it is far longer than our typical video interview.)

An anonymous reader writes "Scientists have discovered a way to convert ordinary skin cells into myelinating cells, or brain cells that have been destroyed in patients with multiple sclerosis, cerebral palsy and other myelin disorders. The research, published in the journal Nature Biotechnology, may now enable 'on demand' production of myelinating cells, which insulate and protect neurons to facilitate the delivery of brain impulses to the rest of the body."